A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics
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A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. / Yew, Yik Weng; Thyssen, Jacob P; Silverberg, Jonathan I.
In: Journal of the American Academy of Dermatology, Vol. 80, No. 2, 02.2019, p. 390-401.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics
AU - Yew, Yik Weng
AU - Thyssen, Jacob P
AU - Silverberg, Jonathan I
N1 - Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2019/2
Y1 - 2019/2
N2 - BACKGROUND: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.OBJECTIVE: To determine the prevalences of AD characteristics and differences by region and age.METHODS: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed a review study titles and/or abstracts and data abstraction.RESULTS: In all, 101 studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification, and xerosis. There were differences in AD characteristics by study region. Flexural involvement was less commonly reported in India, the Americas, and Iran. Studies from East Asian reported more erythroderma and truncal, extensor, scalp, and auricular involvement. Studies from Southeast Asia reported more exudative eczema, truncal involvement, lichenification, and prurigo nodularis. Studies from Iran reported more head, face, and neck involvement; pityriasis alba; and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis, and orbital darkening.LIMITATIONS: Heterogeneity between studies and limited reporting of certain AD clinical characteristics.CONCLUSIONS: AD characteristics are heterogeneous and vary by region and age.
AB - BACKGROUND: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.OBJECTIVE: To determine the prevalences of AD characteristics and differences by region and age.METHODS: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed a review study titles and/or abstracts and data abstraction.RESULTS: In all, 101 studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification, and xerosis. There were differences in AD characteristics by study region. Flexural involvement was less commonly reported in India, the Americas, and Iran. Studies from East Asian reported more erythroderma and truncal, extensor, scalp, and auricular involvement. Studies from Southeast Asia reported more exudative eczema, truncal involvement, lichenification, and prurigo nodularis. Studies from Iran reported more head, face, and neck involvement; pityriasis alba; and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis, and orbital darkening.LIMITATIONS: Heterogeneity between studies and limited reporting of certain AD clinical characteristics.CONCLUSIONS: AD characteristics are heterogeneous and vary by region and age.
KW - Adolescent
KW - Adult
KW - Age of Onset
KW - Biopsy, Needle
KW - Child
KW - Dermatitis, Atopic/diagnosis
KW - Disease Progression
KW - Female
KW - Humans
KW - Immunohistochemistry
KW - Internationality
KW - Male
KW - Prevalence
KW - Prognosis
KW - Risk Assessment
KW - Severity of Illness Index
KW - Young Adult
U2 - 10.1016/j.jaad.2018.09.035
DO - 10.1016/j.jaad.2018.09.035
M3 - Review
C2 - 30287309
VL - 80
SP - 390
EP - 401
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 2
ER -
ID: 235914641