A primer on metabolic memory

A primer on metabolic memory: Why existing diabesity treatments fail

Research output: Contribution to journal › Review › Research › peer-review

Standard

A primer on metabolic memory : Why existing diabesity treatments fail. / Copur, Sidar; Rossing, Peter; Afsar, Baris; Sag, Alan A.; Siriopol, Dimitrie; Kuwabara, Masanari; Ortiz, Alberto; Kanbay, Mehmet.

In: Clinical Kidney Journal, Vol. 14, No. 3, 2021, p. 756-767.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Copur, S, Rossing, P, Afsar, B, Sag, AA, Siriopol, D, Kuwabara, M, Ortiz, A & Kanbay, M 2021, 'A primer on metabolic memory: Why existing diabesity treatments fail', Clinical Kidney Journal, vol. 14, no. 3, pp. 756-767. https://doi.org/10.1093/ckj/sfaa143

APA

Copur, S., Rossing, P., Afsar, B., Sag, A. A., Siriopol, D., Kuwabara, M., Ortiz, A., & Kanbay, M. (2021). A primer on metabolic memory: Why existing diabesity treatments fail. Clinical Kidney Journal, 14(3), 756-767. https://doi.org/10.1093/ckj/sfaa143

Vancouver

Copur S, Rossing P, Afsar B, Sag AA, Siriopol D, Kuwabara M et al. A primer on metabolic memory: Why existing diabesity treatments fail. Clinical Kidney Journal. 2021;14(3):756-767. https://doi.org/10.1093/ckj/sfaa143

Author

Copur, Sidar ; Rossing, Peter ; Afsar, Baris ; Sag, Alan A. ; Siriopol, Dimitrie ; Kuwabara, Masanari ; Ortiz, Alberto ; Kanbay, Mehmet. / A primer on metabolic memory : Why existing diabesity treatments fail. In: Clinical Kidney Journal. 2021 ; Vol. 14, No. 3. pp. 756-767.

Bibtex

@article{45ed2cda4a4c49009e3d74487d87215b,

title = "A primer on metabolic memory: Why existing diabesity treatments fail",

abstract = "Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements. ",

keywords = "chronic kidney disease, diabetic kidney disease, epigenetics, metabolic memory, sirtuin 1",

author = "Sidar Copur and Peter Rossing and Baris Afsar and Sag, {Alan A.} and Dimitrie Siriopol and Masanari Kuwabara and Alberto Ortiz and Mehmet Kanbay",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.",

year = "2021",

doi = "10.1093/ckj/sfaa143",

language = "English",

volume = "14",

pages = "756--767",

journal = "Nephrology Dialysis Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

number = "3",

}

RIS

TY - JOUR

T1 - A primer on metabolic memory

T2 - Why existing diabesity treatments fail

AU - Copur, Sidar

AU - Rossing, Peter

AU - Afsar, Baris

AU - Sag, Alan A.

AU - Siriopol, Dimitrie

AU - Kuwabara, Masanari

AU - Ortiz, Alberto

AU - Kanbay, Mehmet

PY - 2021

Y1 - 2021

N2 - Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

AB - Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.

KW - chronic kidney disease

KW - diabetic kidney disease

KW - epigenetics

KW - metabolic memory

KW - sirtuin 1

U2 - 10.1093/ckj/sfaa143

DO - 10.1093/ckj/sfaa143

M3 - Review

C2 - 34512957

AN - SCOPUS:85118106141

VL - 14

SP - 756

EP - 767

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 3

ER -

ID: 304087375