A low level of CD4+CD28+ T cells is an independent predictor of high mortality in human immunodeficiency virus type 1-infected patients
Research output: Contribution to journal › Journal article › Research › peer-review
This study investigated coexpression of CD28, CD45RA, and CD45RO on CD4(+) and CD8(+) cells in 107 human immunodeficiency virus (HIV) type 1-infected patients, who were followed-up prospectively and were not treated with highly active antiretroviral therapy, and 65 control subjects. The most important novel finding was that a 50% reduction in CD4(+)CD28(+) cells predicted increased mortality (relative hazards [HR], 1.6; 95% confidence interval [CI], 1.0-2.6; P=.04), even after adjusting for the CD4(+) cell counts, virus load, beta(2)-microglobulin and hemoglobin levels, and HIV disease stage. Patients with progressed HIV infection had decreased concentrations of all studied cell subsets. Concerning the proportions of cells, only CD4(+)CD28(+), CD4(+)CD45RA(+), and CD8(+)CD45RO(+) cells decreased with HIV progression. Low proportions of CD4(+)CD45RA(+), CD8(+)CD45RA(+), and CD8(+)CD45RO(+) cells predicted mortality only in univariate but not in multivariate Cox analyses. If our results are confirmed in other studies, coexpression of CD28 on CD4(+) cells may be a useful marker to evaluate HIV progression.
Original language | English |
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Journal | Journal of Infectious Diseases |
Volume | 187 |
Issue number | 11 |
Pages (from-to) | 1726-34 |
Number of pages | 9 |
ISSN | 0022-1899 |
DOIs | |
Publication status | Published - 2003 |
- Adult, Antigens, CD28, Antigens, CD4, Disease Progression, Female, HIV Infections, HIV-1, Humans, Lymphocyte Count, Male, Middle Aged, Multivariate Analysis, Phenotype, Survival Analysis, T-Lymphocyte Subsets, Viral Load
Research areas
ID: 36144484