Alcohol use in schizophrenia is associated with poorer outcomes, such as increased suicidality and positive symptoms (Lv et al., 2023). Both alcohol use and psychosis have been independently associated with changes in brain glutamate levels. However, whether alcohol use impacts brain glutamate levels in people with psychosis is unknown. Potentially, overlapping glutamatergic pathophysiology could mean that, patients with schizophrenia are more vulnerable to the effects of alcohol.