A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System
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A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System. / Bhumika, Stitipragyan; Nakamura, Mari; Valerio, Patricia; Solyga, Magdalena; Lindén, Henrik; Barkat, Tania R.
In: Cerebral Cortex, Vol. 30, No. 4, 2020, p. 2586-2599.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A Late Critical Period for Frequency Modulated Sweeps in the Mouse Auditory System
AU - Bhumika, Stitipragyan
AU - Nakamura, Mari
AU - Valerio, Patricia
AU - Solyga, Magdalena
AU - Lindén, Henrik
AU - Barkat, Tania R.
PY - 2020
Y1 - 2020
N2 - Neuronal circuits are shaped by experience during time windows of increased plasticity in postnatal development. In the auditory system, the critical period for the simplest sounds-pure frequency tones-is well defined. Critical periods for more complex sounds remain to be elucidated. We used in vivo electrophysiological recordings in the mouse auditory cortex to demonstrate that passive exposure to frequency modulated sweeps (FMS) from postnatal day 31 to 38 leads to long-Term changes in the temporal representation of sweep directions. Immunohistochemical analysis revealed a decreased percentage of layer 4 parvalbumin-positive (PV+) cells during this critical period, paralleled with a transient increase in responses to FMS, but not to pure tones. Preventing the PV+ cell decrease with continuous white noise exposure delayed the critical period onset, suggesting a reduction in inhibition as a mechanism for this plasticity. Our findings shed new light on the dependence of plastic windows on stimulus complexity that persistently sculpt the functional organization of the auditory cortex.
AB - Neuronal circuits are shaped by experience during time windows of increased plasticity in postnatal development. In the auditory system, the critical period for the simplest sounds-pure frequency tones-is well defined. Critical periods for more complex sounds remain to be elucidated. We used in vivo electrophysiological recordings in the mouse auditory cortex to demonstrate that passive exposure to frequency modulated sweeps (FMS) from postnatal day 31 to 38 leads to long-Term changes in the temporal representation of sweep directions. Immunohistochemical analysis revealed a decreased percentage of layer 4 parvalbumin-positive (PV+) cells during this critical period, paralleled with a transient increase in responses to FMS, but not to pure tones. Preventing the PV+ cell decrease with continuous white noise exposure delayed the critical period onset, suggesting a reduction in inhibition as a mechanism for this plasticity. Our findings shed new light on the dependence of plastic windows on stimulus complexity that persistently sculpt the functional organization of the auditory cortex.
KW - auditory cortex
KW - frequency modulated sweep
KW - juvenile development
KW - parvalbumin positive neurons
KW - sensory processing
U2 - 10.1093/cercor/bhz262
DO - 10.1093/cercor/bhz262
M3 - Journal article
C2 - 31800018
AN - SCOPUS:85083912773
VL - 30
SP - 2586
EP - 2599
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 4
ER -
ID: 242707570