A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

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A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. / Bell, Steven; Rigas, Andreas S.; Magnusson, Magnus K.; Ferkingstad, Egil; Allara, Elias; Bjornsdottir, Gyda; Ramond, Anna; Sørensen, Erik; Halldorsson, Gisli H.; Paul, Dirk S.; Burgdorf, Kristoffer S.; Eggertsson, Hannes P.; Howson, Joanna M.M.; Thørner, Lise W.; Kristmundsdottir, Snaedis; Astle, William J.; Erikstrup, Christian; Sigurdsson, Jon K.; Vuckovic, Dragana; Dinh, Khoa M.; Tragante, Vinicius; Surendran, Praveen; Pedersen, Ole B.; Vidarsson, Brynjar; Jiang, Tao; Paarup, Helene M.; Onundarson, Pall T.; Akbari, Parsa; Nielsen, Kaspar R.; Lund, Sigrun H.; Juliusson, Kristinn; Magnusson, Magnus I.; Frigge, Michael L.; Oddsson, Asmundur; Olafsson, Isleifur; Kaptoge, Stephen; Hjalgrim, Henrik; Runarsson, Gudmundur; Wood, Angela M.; Hansen, Thomas F.; Burgdorf, Kristoffer S.; Jemec, Gregor; Jennum, Poul; Nielsen, Kasper R.; Petersen, Mikkel; Werge, Thomas; Westergaard, David; Banasik, Karina; Brunak, Søren; Ullum, Henrik; DBDS Genomic Consortium.

In: Communications Biology , Vol. 4, No. 1, 156, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bell, S, Rigas, AS, Magnusson, MK, Ferkingstad, E, Allara, E, Bjornsdottir, G, Ramond, A, Sørensen, E, Halldorsson, GH, Paul, DS, Burgdorf, KS, Eggertsson, HP, Howson, JMM, Thørner, LW, Kristmundsdottir, S, Astle, WJ, Erikstrup, C, Sigurdsson, JK, Vuckovic, D, Dinh, KM, Tragante, V, Surendran, P, Pedersen, OB, Vidarsson, B, Jiang, T, Paarup, HM, Onundarson, PT, Akbari, P, Nielsen, KR, Lund, SH, Juliusson, K, Magnusson, MI, Frigge, ML, Oddsson, A, Olafsson, I, Kaptoge, S, Hjalgrim, H, Runarsson, G, Wood, AM, Hansen, TF, Burgdorf, KS, Jemec, G, Jennum, P, Nielsen, KR, Petersen, M, Werge, T, Westergaard, D, Banasik, K, Brunak, S, Ullum, H & DBDS Genomic Consortium 2021, 'A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis', Communications Biology , vol. 4, no. 1, 156. https://doi.org/10.1038/s42003-020-01575-z

APA

Bell, S., Rigas, A. S., Magnusson, M. K., Ferkingstad, E., Allara, E., Bjornsdottir, G., Ramond, A., Sørensen, E., Halldorsson, G. H., Paul, D. S., Burgdorf, K. S., Eggertsson, H. P., Howson, J. M. M., Thørner, L. W., Kristmundsdottir, S., Astle, W. J., Erikstrup, C., Sigurdsson, J. K., Vuckovic, D., ... DBDS Genomic Consortium (2021). A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Communications Biology , 4(1), [156]. https://doi.org/10.1038/s42003-020-01575-z

Vancouver

Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Communications Biology . 2021;4(1). 156. https://doi.org/10.1038/s42003-020-01575-z

Author

Bell, Steven ; Rigas, Andreas S. ; Magnusson, Magnus K. ; Ferkingstad, Egil ; Allara, Elias ; Bjornsdottir, Gyda ; Ramond, Anna ; Sørensen, Erik ; Halldorsson, Gisli H. ; Paul, Dirk S. ; Burgdorf, Kristoffer S. ; Eggertsson, Hannes P. ; Howson, Joanna M.M. ; Thørner, Lise W. ; Kristmundsdottir, Snaedis ; Astle, William J. ; Erikstrup, Christian ; Sigurdsson, Jon K. ; Vuckovic, Dragana ; Dinh, Khoa M. ; Tragante, Vinicius ; Surendran, Praveen ; Pedersen, Ole B. ; Vidarsson, Brynjar ; Jiang, Tao ; Paarup, Helene M. ; Onundarson, Pall T. ; Akbari, Parsa ; Nielsen, Kaspar R. ; Lund, Sigrun H. ; Juliusson, Kristinn ; Magnusson, Magnus I. ; Frigge, Michael L. ; Oddsson, Asmundur ; Olafsson, Isleifur ; Kaptoge, Stephen ; Hjalgrim, Henrik ; Runarsson, Gudmundur ; Wood, Angela M. ; Hansen, Thomas F. ; Burgdorf, Kristoffer S. ; Jemec, Gregor ; Jennum, Poul ; Nielsen, Kasper R. ; Petersen, Mikkel ; Werge, Thomas ; Westergaard, David ; Banasik, Karina ; Brunak, Søren ; Ullum, Henrik ; DBDS Genomic Consortium. / A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. In: Communications Biology . 2021 ; Vol. 4, No. 1.

Bibtex

@article{044c477ec23a4e0cba45bc36a4d77c00,
title = "A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis",
abstract = "Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.",
author = "Steven Bell and Rigas, {Andreas S.} and Magnusson, {Magnus K.} and Egil Ferkingstad and Elias Allara and Gyda Bjornsdottir and Anna Ramond and Erik S{\o}rensen and Halldorsson, {Gisli H.} and Paul, {Dirk S.} and Burgdorf, {Kristoffer S.} and Eggertsson, {Hannes P.} and Howson, {Joanna M.M.} and Th{\o}rner, {Lise W.} and Snaedis Kristmundsdottir and Astle, {William J.} and Christian Erikstrup and Sigurdsson, {Jon K.} and Dragana Vuckovic and Dinh, {Khoa M.} and Vinicius Tragante and Praveen Surendran and Pedersen, {Ole B.} and Brynjar Vidarsson and Tao Jiang and Paarup, {Helene M.} and Onundarson, {Pall T.} and Parsa Akbari and Nielsen, {Kaspar R.} and Lund, {Sigrun H.} and Kristinn Juliusson and Magnusson, {Magnus I.} and Frigge, {Michael L.} and Asmundur Oddsson and Isleifur Olafsson and Stephen Kaptoge and Henrik Hjalgrim and Gudmundur Runarsson and Wood, {Angela M.} and Hansen, {Thomas F.} and Burgdorf, {Kristoffer S.} and Gregor Jemec and Poul Jennum and Nielsen, {Kasper R.} and Mikkel Petersen and Thomas Werge and David Westergaard and Karina Banasik and S{\o}ren Brunak and Henrik Ullum and {DBDS Genomic Consortium}",
year = "2021",
doi = "10.1038/s42003-020-01575-z",
language = "English",
volume = "4",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

AU - Bell, Steven

AU - Rigas, Andreas S.

AU - Magnusson, Magnus K.

AU - Ferkingstad, Egil

AU - Allara, Elias

AU - Bjornsdottir, Gyda

AU - Ramond, Anna

AU - Sørensen, Erik

AU - Halldorsson, Gisli H.

AU - Paul, Dirk S.

AU - Burgdorf, Kristoffer S.

AU - Eggertsson, Hannes P.

AU - Howson, Joanna M.M.

AU - Thørner, Lise W.

AU - Kristmundsdottir, Snaedis

AU - Astle, William J.

AU - Erikstrup, Christian

AU - Sigurdsson, Jon K.

AU - Vuckovic, Dragana

AU - Dinh, Khoa M.

AU - Tragante, Vinicius

AU - Surendran, Praveen

AU - Pedersen, Ole B.

AU - Vidarsson, Brynjar

AU - Jiang, Tao

AU - Paarup, Helene M.

AU - Onundarson, Pall T.

AU - Akbari, Parsa

AU - Nielsen, Kaspar R.

AU - Lund, Sigrun H.

AU - Juliusson, Kristinn

AU - Magnusson, Magnus I.

AU - Frigge, Michael L.

AU - Oddsson, Asmundur

AU - Olafsson, Isleifur

AU - Kaptoge, Stephen

AU - Hjalgrim, Henrik

AU - Runarsson, Gudmundur

AU - Wood, Angela M.

AU - Hansen, Thomas F.

AU - Burgdorf, Kristoffer S.

AU - Jemec, Gregor

AU - Jennum, Poul

AU - Nielsen, Kasper R.

AU - Petersen, Mikkel

AU - Werge, Thomas

AU - Westergaard, David

AU - Banasik, Karina

AU - Brunak, Søren

AU - Ullum, Henrik

AU - DBDS Genomic Consortium

PY - 2021

Y1 - 2021

N2 - Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.

AB - Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.

U2 - 10.1038/s42003-020-01575-z

DO - 10.1038/s42003-020-01575-z

M3 - Journal article

C2 - 33536631

AN - SCOPUS:85100560134

VL - 4

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 156

ER -

ID: 258041238