A cortical source localization analysis of resting EEG data after remifentanil infusion
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
A cortical source localization analysis of resting EEG data after remifentanil infusion. / Khodayari-Rostamabad, Ahmad; Graversen, Carina; Malver, Lasse P; Kurita, Geana P; Christrup, Lona Louring; Sjøgren, Per; Drewes, Asbjørn M.
In: Clinical Neurophysiology, Vol. 126, No. 5, 2015, p. 898-905.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A cortical source localization analysis of resting EEG data after remifentanil infusion
AU - Khodayari-Rostamabad, Ahmad
AU - Graversen, Carina
AU - Malver, Lasse P
AU - Kurita, Geana P
AU - Christrup, Lona Louring
AU - Sjøgren, Per
AU - Drewes, Asbjørn M
N1 - Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: To explore changes in current source density locations after remifentanil infusion in healthy volunteers using source localization of the electroencephalography (EEG).METHODS: EEG data was collected from 21 males using a 62-electrode system. Additionally, cognitive performance was evaluated by a continuous reaction time paradigm, and pain scores were obtained for experimental bone and heat stimuli. Data were recorded before and during treatment with remifentanil and placebo. Source localization was performed by sLORETA at delta (1-3.9Hz), theta (4-7.9Hz), alpha (8-12Hz), beta1 (12.1-18Hz), and beta2 (18.1-30Hz) frequency bands.RESULTS: Pre-treatment recordings demonstrated reproducible source characteristics. The alterations (i.e., pre- versus post-treatment) due to remifentanil were significantly and robustly different from placebo infusions. The results indicated that neurons in several brain areas including inferior frontal gyrus and insula at frontal lobe oscillated more strongly after remifentanil infusion compared to placebo. Furthermore, the source activity at delta band was correlated with continuous reaction time index.CONCLUSIONS: These results indicate that alterations in brain oscillations during remifentanil are mostly localized to frontal, fronto-temporal and fronto-central lobes and related to cognitive function.SIGNIFICANCE: The approach offers the potential to be used for understanding the underlying mechanism of action of remifentanil on brain activity.
AB - OBJECTIVE: To explore changes in current source density locations after remifentanil infusion in healthy volunteers using source localization of the electroencephalography (EEG).METHODS: EEG data was collected from 21 males using a 62-electrode system. Additionally, cognitive performance was evaluated by a continuous reaction time paradigm, and pain scores were obtained for experimental bone and heat stimuli. Data were recorded before and during treatment with remifentanil and placebo. Source localization was performed by sLORETA at delta (1-3.9Hz), theta (4-7.9Hz), alpha (8-12Hz), beta1 (12.1-18Hz), and beta2 (18.1-30Hz) frequency bands.RESULTS: Pre-treatment recordings demonstrated reproducible source characteristics. The alterations (i.e., pre- versus post-treatment) due to remifentanil were significantly and robustly different from placebo infusions. The results indicated that neurons in several brain areas including inferior frontal gyrus and insula at frontal lobe oscillated more strongly after remifentanil infusion compared to placebo. Furthermore, the source activity at delta band was correlated with continuous reaction time index.CONCLUSIONS: These results indicate that alterations in brain oscillations during remifentanil are mostly localized to frontal, fronto-temporal and fronto-central lobes and related to cognitive function.SIGNIFICANCE: The approach offers the potential to be used for understanding the underlying mechanism of action of remifentanil on brain activity.
U2 - 10.1016/j.clinph.2014.08.006
DO - 10.1016/j.clinph.2014.08.006
M3 - Journal article
C2 - 25227220
VL - 126
SP - 898
EP - 905
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 5
ER -
ID: 129173898