20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials
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20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials. / Guo, Xiong; Xiu, Fangfang; Bera, Hriday; Abbasi, Yasir Faraz; Chen, Yang; Si, Liangwei; Liu, Peixin; Zhao, Chunwei; Tang, Xing; Feng, Yu; Cun, Dongmei; Zhao, Xia; Yang, Mingshi.
In: Carbohydrate Polymers, Vol. 317, 121085, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials
AU - Guo, Xiong
AU - Xiu, Fangfang
AU - Bera, Hriday
AU - Abbasi, Yasir Faraz
AU - Chen, Yang
AU - Si, Liangwei
AU - Liu, Peixin
AU - Zhao, Chunwei
AU - Tang, Xing
AU - Feng, Yu
AU - Cun, Dongmei
AU - Zhao, Xia
AU - Yang, Mingshi
N1 - Funding Information: This work was financially supported by the Liaoning Pan Deng Xue Zhe Scholar (No. XLYC2002061 ), the National Natural Science Foundation of China (No. 82173768 ), and the Overseas Expertise Introduction Project for Discipline Innovation (“ 111 Project ”) (No. D20029 ). X. G. acknowledges the Educational Department of Liaoning Province (grant No. LJKZ0925 ), ( Youth Project , grant No. LJKQZ2021035 ), the international postdoctoral exchange fellowship program (grant No. PC2021047 ) and Liaoning Provincial Doctoral Research Start-Up Fund (grant No. 2023-BS-110 ). H. B. thanks the financial support from National Natural Science Foundation of China (grant No. 82050410448 ) and Fellowship of China Postdoctoral Science Foundation (grant No. 2021MD703857 ). D.Cun acknowledges financial support from the General Project of Science and Technology Research Project of Liaoning Province (No. 2022-MS-241 ), and Ministry of Education Chunhui Program ( 2020 ).
PY - 2023
Y1 - 2023
N2 - The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring. In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols. The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars. The PU/HACC/SA/Rg3 dressings showed a sandwich-like structure. The Rg3 was encapsulated in the middle layers of these NFDs and slowly released over 30 days. The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs. These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model. Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin. Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
AB - The management of deep burn injuries is extremely challenging, ascribed to their delayed wound healing rate, susceptibility for bacterial infections, pain, and increased risk of hypertrophic scarring. In our current investigation, a series of composite nanofiber dressings (NFDs) based on polyurethane (PU) and marine polysaccharides (i.e., hydroxypropyl trimethyl ammonium chloride chitosan, HACC and sodium alginate, SA) were accomplished by electrospinning and freeze-drying protocols. The 20(R)-ginsenoside Rg3 (Rg3) was further loaded into these NFDs to inhibit the formation of excessive wound scars. The PU/HACC/SA/Rg3 dressings showed a sandwich-like structure. The Rg3 was encapsulated in the middle layers of these NFDs and slowly released over 30 days. The PU/HACC/SA and PU/HACC/SA/Rg3 composite dressings demonstrated superior wound healing potentials over other NFDs. These dressings also displayed favorable cytocompatibility with keratinocytes and fibroblasts and could dramatically accelerate epidermal wound closure rate following 21 days of the treatment of a deep burn wound animal model. Interestingly, the PU/HACC/SA/Rg3 obviously reduced the excessive scar formation, with a collagen type I/III ratio closer to the normal skin. Overall, this study represented PU/HACC/SA/Rg3 as a promising multifunctional wound dressing, which promoted the regeneration of burn skins and attenuated scar formation.
KW - Ginsenoside
KW - Hydroxypropyl trimethyl ammonium chloride chitosan
KW - Nanofibrous scaffolds
KW - Polyurethane
KW - Sodium alginate
KW - Third-degree burn
U2 - 10.1016/j.carbpol.2023.121085
DO - 10.1016/j.carbpol.2023.121085
M3 - Journal article
C2 - 37364955
AN - SCOPUS:85163162814
VL - 317
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
M1 - 121085
ER -
ID: 359542776