1,4-Anhydro-4-seleno-d-talitol (SeTal): a remarkable selenium-containing therapeutic molecule
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1,4-Anhydro-4-seleno-d-talitol (SeTal) : a remarkable selenium-containing therapeutic molecule. / Davies, Michael J.; Schiesser, Carl H.
In: New Journal of Chemistry, Vol. 43, No. 25, 2019, p. 9759-9765.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - 1,4-Anhydro-4-seleno-d-talitol (SeTal)
T2 - a remarkable selenium-containing therapeutic molecule
AU - Davies, Michael J.
AU - Schiesser, Carl H.
PY - 2019
Y1 - 2019
N2 - It is well accepted that organoselenium compounds are powerful antioxidants that have potential therapeutic benefits. Unfortunately, the therapeutic value of many of these selenium-containing entities is often hampered by low solubility in aqueous solutions, which prevents them from reaching therapeutically relevant doses in plasma. We approached this problem by constructing selenosugars with infinite water solubilities. Work over many years led to the discovery of 1,4-anhydro-4-seleno-d-tallitol (SeTal), which has been shown to accelerate skin-tissue repair, heal wounds in (db/db and wt) rodent and porcine models, and prevent high-glucose-induced endothelial dysfunction in mouse aorta. This lead compound is currently being developed as a topical medicament for a variety of skin-repair scenarios. This article discusses the chemistry that led to the development of our selenium-containing carbohydrates, and showcases the remarkable therapeutic properties of SeTal.
AB - It is well accepted that organoselenium compounds are powerful antioxidants that have potential therapeutic benefits. Unfortunately, the therapeutic value of many of these selenium-containing entities is often hampered by low solubility in aqueous solutions, which prevents them from reaching therapeutically relevant doses in plasma. We approached this problem by constructing selenosugars with infinite water solubilities. Work over many years led to the discovery of 1,4-anhydro-4-seleno-d-tallitol (SeTal), which has been shown to accelerate skin-tissue repair, heal wounds in (db/db and wt) rodent and porcine models, and prevent high-glucose-induced endothelial dysfunction in mouse aorta. This lead compound is currently being developed as a topical medicament for a variety of skin-repair scenarios. This article discusses the chemistry that led to the development of our selenium-containing carbohydrates, and showcases the remarkable therapeutic properties of SeTal.
U2 - 10.1039/c9nj02185j
DO - 10.1039/c9nj02185j
M3 - Review
VL - 43
SP - 9759
EP - 9765
JO - New Journal of Chemistry
JF - New Journal of Chemistry
SN - 1144-0546
IS - 25
ER -
ID: 223923001