Trond Ulven
Professor
- 2011
Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties
Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Novel CRTH2 antagonists: a review of patents from 2006 to 2009
Ulven, Trond & Kostenis, E., 1 Nov 2010, In: Expert Opinion on Therapeutic Patents. 20, 11, p. 1505-1530 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists
Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compounds for the treatment of metabolic diseases
Ulven, Trond & Christiansen, E., 4 Feb 2010, Patent No. WO 2010/012650Research output: Patent
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2
Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Macrocyclic G-quadruplex ligands
Nielsen, M. C. & Ulven, Trond, 1 Jan 2010, In: Current Medicinal Chemistry. 17, 29, p. 3438-3448 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469
Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Targeting the prostaglandin D2 receptors DP1 and CRTH2 for treatment of inflammation
Ulven, Trond & Kostenis, E., 2010, Frontiers in Medicinal Chemistry. Bentham Science Publishers, Vol. 5.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2009
- Published
Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands
Nielsen, M. C., Borch, J. & Ulven, Trond, 15 Dec 2009, In: Bioorganic & Medicinal Chemistry. 17, 24, p. 8241-8246 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
Rist, O., Grimstrup, M., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Kostenis, E. & Högberg, T., 4 Dec 2009, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1177-1180 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands
Petersen, T. P., Ritzén, A. & Ulven, Trond, 19 Nov 2009, In: Organic Letters. 11, 22, p. 5134-5137 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
1,2-Dihydrospiro[carbazole-3(4H),2'-[1,3]dioxolane]
Bjerrum, J. V., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o579Research output: Contribution to journal › Journal article › Research › peer-review
- Published
4-Fluoro-N-methyl-N-(1,2,3,4-tetrahydrocarbazol-3-yl)benzenesulfonamide
Rasmussen, K. G., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o742Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclopropyl and cyclobutyl epothilone analogs
Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M. & Altmann, K., 2009, Patent No. EP 1,420,780 B1Research output: Patent
- Published
Discovery and structure-activity relationship investigations of 4-arylethynyldihydrocinnamic acid agonists of the antidiabetic target free fatty acid receptor 1
Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 2009.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Ethyl 2-(1,2,3,4-tetrahydrospiro[carbazole-3,2'- [1,3]dioxolan]-9-yl)acetate
Loffler, P., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, Section E, p. o685Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extraction of G-quadruplex ligands from disulfide-based dynamic combinatorial libraries
Nielsen, Mads & Ulven, Trond, 2009, p. ORGN-345.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Flow chemistry methods for the synthesis chemokine receptor ligands
Petersen, T. P., Ritzén, A. & Ulven, Trond, 2009, p. ORGN-570.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI- and downstream-signaling cascade activation
Schroeder, R., Merten, N., Mathiesen, Jesper M., Martini, L., Letunic, A. K., Krop, F., Blaukat, A., Fang, Y., Tran, E., Ulven, Trond, Drewke, C., Whistler, J., Pardo, L., Gomeza, J. & Kostenis, E., 2009, In: Journal of Biological Chemistry. 284, 2, p. 1324-1336 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes
Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective extraction of G-quadruplex ligands from a rationally designed scaffold-based dynamic combinatorial library
Nielsen, M. C. & Ulven, Trond, 1 Jan 2008, In: Chemistry: A European Journal. 14, 31, p. 9487-9490 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst
Royer, J. F., Schratl, P., Lorenz, S., Kostenis, E., Ulven, Trond, Schuligoi, R., Peskar, B. A. & Heinemann, A., 1 Dec 2007, In: Allergy. 62, 12, p. 1401-1409 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2
Ulven, Trond, Gallen, M. J., Nielsen, M. C., Merten, N., Schmidt, C., Mohr, K., Tränkle, C. & Kostenis, E., 1 Nov 2007, In: Bioorganic & Medicinal Chemistry Letters. 17, 21, p. 5924-5927 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking
Schratl, P., Royer, J. F., Kostenis, E., Ulven, Trond, Sturm, E. M., Waldhoer, M., Hoefler, G., Schuligoi, R., Lippe, I. T., Peskar, B. A. & Heinemann, A., 1 Oct 2007, In: Journal of Immunology. 179, 7, p. 4792-4799 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
Uller, L., Mathiesen, Jesper M., Alenmyr, L., Korsgren, M., Ulven, Trond, Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 Feb 2007, In: Respiratory Research. 8, 16Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phenoxyacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062678 A1Research output: Patent
- Published
Thiazole- and pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2007, Patent No. WO 2007/062677 A1Research output: Patent
- 2006
- Published
6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists
Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging roles of DP and CRTH2 in allergic inflammation
Kostenis, E. & Ulven, Trond, 2006, In: Trends in Molecular Medicine. 12, 4, p. 148-158 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
Ulven, Trond, Receveur, J., Grimstrup, M., Rist, Ø., Frimurer, Thomas Michael, Gerlach, L., Mathiesen, Jesper M., Kostenis, E., Uller, L. & Högberg, T., 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6638-6641 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2
Mathiesen, Jesper M., Christopoulos, A., Ulven, Trond, Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In: Molecular Pharmacology. 69, 4, p. 1441-1453 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting G protein-coupled 7TM receptors in treatment of inflammation
Ulven, Trond, 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1317-1318 2 p.Research output: Contribution to journal › Journal article › Research
- Published
Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation
Ulven, Trond & Kostenis, E., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1427-1444 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists
Ulven, Trond, Frimurer, Thomas Michael, Receveur, J., Little, P. B., Rist, Ø., Nørregaard, P. K. & Högberg, T., 2005, In: Journal of Medicinal Chemistry. 48, 18, p. 5684-5697 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A physicogenetic method to assign ligand-binding relationships between 7TM receptors
Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CRTH2 receptor ligands for therapeutic use
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1Research output: Patent
- Published
CRTH2 receptor ligands for therapeutic use - B-series
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E. & Högberg, T., 2005, Patent No. WO 2005/115374 A1Research output: Patent
- Published
Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2
Mathiesen, Jesper M., Ulven, Trond, Martin, L., Gerlach, L., Heinemann, A. & Kostenis, E., 2005, In: Molecular Pharmacology. 68, 2, p. 393-402 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minor Structural Modifications Convert the Dual TP/CRTH2 Antagonist Ramatroban into a Highly Selective and Potent CRTH2 Antagonist
Ulven, Trond & Kostenis, E., 2005, In: Journal of Medicinal Chemistry. 48, 4, p. 897-900 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of phenyl benzoyl pyrazoles as CRTH2 receptor ligands
Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1Research output: Patent
- Published
Preparation of substituted thiazoleacetic acids as CRTH2 receptor ligands
Ulven, Trond, Frimurer, Thomas Michael, Rist, O., Kostenis, E., Hoegberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1Research output: Patent
- Published
Quinazoline compounds and their use in MCH-related disease
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/123714Research output: Patent
- Published
Substituted thiazoleacetic acids as CRTH2 receptor ligands
Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/116001 A1Research output: Patent
- 2004
- Published
4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists
Receveur, J., Bjurling, E., Ulven, Trond, Little, P. B., Nørregaard, P. K. & Högberg, T., 18 Oct 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 20, p. 5075-5080 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625Research output: Patent
- Published
Cyclic Quinoline compounds for use in MCH receptor related disorders
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371Research output: Patent
- Published
Novel benzamide compounds for use in MCH receptor related disorders
Högberg, T., Bjurling, A. E., Receveur, J., Ulven, Trond, Elling, C. E. & Nørregaard, P. K., 2004, Patent No. WO 2004/048319Research output: Patent
- Published
Quinoline compounds for use in MCH receptor related disorders
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370Research output: Patent
- 2002
- Published
Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries
Nicolaou, K. C., Montagnon, T., Ulven, Trond, Baran, P. S., Zhong, Y. & Sarabia, F., 22 May 2002, In: American Chemical Society. Journal. 124, 20, p. 5718-5728 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 187375453
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Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties
Research output: Contribution to journal › Journal article › Research › peer-review
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Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival
Research output: Contribution to journal › Journal article › Research › peer-review
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Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum
Research output: Contribution to journal › Journal article › Research › peer-review
Published