Trond Ulven

Trond Ulven

Professor

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    ORCID: 0000-0002-8135-1755

    Publication year:
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    51 - 100 out of 157Page size: 50
    1. 2016

    2. Controlled generation and use of CO in flow

      Hansen, S. V. F., Wilson, Z. E., Ulven, Trond & Ley, S. V., 2016, In: Reaction Chemistry & Engineering. 1, 3, p. 280-287 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

      Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120

      Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, Trond, Miller, A. M., Tobin, A. B. & Milligan, G., 2016, In: Molecular Pharmacology. 89, 5, p. 505-520 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

      Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands

      Sergeev, E., Hojgaard Hansen, A., Pandey, S. K., Mackenzie, A. E., Hudson, B. D., Ulven, Trond & Milligan, G., 2016, In: Journal of Biological Chemistry. 291, p. 303-317 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

      Björkman, L., Mårtensson, J., Winther, M., Gabl, M., Holdfeldt, A., Uhrbom, M., Bylund, J., Højgaard Hansen, A., Pandey, S. K., Ulven, Trond, Forsman, H. & Dahlgren, C., 2016, In: Molecular and Cellular Biology. 36, 20, p. 2583-2595 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

      Gozal, D., Qiao, Z., Almendros, I., Zheng, J., Khalyfa, A., Shimpukade, B. & Ulven, Trond, 2016, In: International Journal of Obesity. 40, 7, p. 1143-1149 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2015
    10. Published

      Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

      Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Oxalyl chloride as a practical carbon monoxide source for carbonylation reactions

      Hansen, S. V. F. & Ulven, Trond, 5 Jun 2015, In: Organic Letters. 17, 11, p. 2832-2835 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Characterising pharmacological ligands to study the long chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

      Milligan, G., Alvarez-Curto, E., Watterson, K. R., Ulven, Trond & Hudson, B. D., 2015, In: British Journal of Pharmacology. 172, 13, p. 3254-3265 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MSALL

      Sokol, O., Ulven, Trond, Færgeman, N. J. & Ejsing, C. S., 2015, In: European Journal of Lipid Science and Technology. 117, 6, p. 751-759 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. 2014

    15. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

      Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120)

      Hudson, B. D., Shimpukade, B., Milligan, G. & Ulven, Trond, 18 Jul 2014, In: Journal of Biological Chemistry. 289, 29, p. 20345-20358 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

      Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, Trond, Milligan, G. & Tobin, A. B., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18451-18465 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Direct N9-arylation of purines with aryl halides

      Larsen, A. F. & Ulven, Trond, 21 May 2014, In: Chemical Communications. 50, 39, p. 4997-4999 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. G-protein-coupled receptors for free fatty acids

      Milligan, G., Ulven, Trond, Murdoch, H. & Hudson, B. D., 2 Jan 2014, In: British Journal of Nutrition. 111, Supplement S1, p. S3-S7

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Phenanthroline-2,9-bistriazoles as selective G-quadruplex ligands

      Nielsen, M. C., Larsen, A. F., Abdikadir, F. H. & Ulven, Trond, 2014, In: European Journal of Medicinal Chemistry. 72, p. 119-126 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Treatment of type 2 diabetes by free Fatty Acid receptor agonists

      Watterson, K. R., Hudson, B. D., Ulven, Trond & Milligan, G., 2014, In: Frontiers in Endocrinology. 5

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2013
    23. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 19 Dec 2013, Patent No. WO 2013/185766 A1

      Research output: Patent

    24. Published

      Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

      Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      GPR120 receptor modulators

      Ulven, Trond & Shimpukade, B., 26 Sep 2013, Patent No. WO 2013/139341 A1

      Research output: Patent

    26. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469

      Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Gohlke, H. & Kassack, M. U., 17 Jul 2013, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030 1010 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Multistep Continuous-Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure-Activity Relationships of CCR8 Ligands

      Petersen, T. P., Mirsharghi, S., Rummel, P. C., Thiele, S., Rosenkilde, Mette, Ritzén, A. & Ulven, Trond, 8 Jul 2013, In: Chemistry: A European Journal. 19, 28, p. 9343-50 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

      Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Discovery of TUG-770

      Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Reevaluation of Fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans

      Wagner, R., Kaiser, G., Gerst, F., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Grundmann, M., Machicao, F., Peter, A., Kostenis, E., Ulven, Trond, Fritsche, A., Häring, H. & Ullrich, S., 1 Feb 2013, In: Diabetes. 62, 6, p. 2106-2111 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

      Hudson, B. D., Ulven, Trond & Milligan, G., 1 Jan 2013, In: Current Topics in Medicinal Chemistry. 13, 1, p. 14-25 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

      Petersen, T. P., Larsen, A. F., Ritzén, A. & Ulven, Trond, 2013, In: Journal of Organic Chemistry. 78, 8, p. 4190-4195 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Mucus can change the permeation rank order of drug candidates

      Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Selective copper catalysed aromatic N-arylation in water

      Engel-Andreasen, J., Shimpukade, B. & Ulven, Trond, 2013, In: Green Chemistry. 15, 2, p. 336-340 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

      Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. 2012
    38. Published

      Preparation of ortho-fluoro substituted compounds for the treatment of metabolic diseases.

      Ulven, Trond & Christiansen, E., 11 Oct 2012, Patent No. WO 2012/136221A1

      Research output: Patent

    39. Published

      Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

      Thiele, S., Malmgaard-Clausen, M., Engel-Andreasen, J., Steen, A., Rummel, P. C., Nielsen, M. C., Gloriam, David E., Frimurer, Thomas Michael, Ulven, Trond & Rosenkilde, Mette, 27 Sep 2012, In: Journal of Medicinal Chemistry. 55, 18, p. 8164-77 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Antidiabetic enolic glucoside of phenylpyruvic acid.

      Joubert, E., Fey, S. J., Louw, J., Ulven, Trond & Tyagi, R., 12 Apr 2012, Patent No. WO 2012/045363A1

      Research output: Patent

    41. Published

      A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

      Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

      Tyagi, R., Shimpukade, B., Blättermann, S., Kostenis, E. & Ulven, Trond, 2012, In: MedChemComm. 3, p. 195-198 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

      Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Discovery of a potent and selective GPR120 agonist

      Shimpukade, B., Hudson, B. D., Hovgaard, C. K., Milligan, G. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4511-4515 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

      Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2

      Schröder, R., Xue, L., Konya, V., Martini, L., Kampitsch, N., Whistler, J. L., Ulven, Trond, Heinemann, A., Pettipher, R. & Kostenis, E., 2012, In: P L o S One. 7, 3, p. e33329

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

      Ulven, Trond, 2012, In: Frontiers in Endocrinology. 3

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Tetrasubstituted phenanthrolines as highly potent, water-soluble, and selective g-quadruplex ligands

      Larsen, A. F., Nielsen, M. C. & Ulven, Trond, 2012, In: Chemistry: A European Journal. 18, 35, p. 10892-10902 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      The oxygen-mediated synthesis of 1,3-butadiynes in continuous flow

      Petersen, T. P., Polyzos, A., O'Brien, M., Ulven, Trond, Baxendale, I. R. & Ley, S. V., 2012, In: ChemSusChem (Print). 5, 2, p. 274-277 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2011
    52. Published

      Method of synthesizing a 5-oxo-conjugated fatty acid

      Ulven, Trond & Tyagi, R., 27 Oct 2011, Patent No. WO 2011/131619 A1

      Research output: Patent

    53. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

      Schmidt, J., Smith, N. J., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, Trond, 10 Jan 2011, In: Journal of Biological Chemistry. 286, 12, p. 10628-10640 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

      Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In: Journal of Biological Chemistry. 286, 14, p. 11890-11894 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxamides

      Larsen, A. F. & Ulven, Trond, 2011, In: Organic Letters. 13, 13, p. 3546-3548 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Extracellular loop 2 of the free Fatty Acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

      Smith, N. J., Ward, R. J., Stoddart, L. A., Hudson, B. D., Kostenis, E., Ulven, Trond, Morris, J. C., Tränkle, C., Tikhonova, I. G., Adams, D. R. & Milligan, G., 2011, In: Molecular Pharmacology. 80, 1, p. 163-173 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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