Trond Ulven

Trond Ulven

Professor

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    ORCID: 0000-0002-8135-1755

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    1. Published

      1,2-Dihydrospiro[carbazole-3(4H),2'-[1,3]dioxolane]

      Bjerrum, J. V., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o579

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

      Receveur, J., Bjurling, E., Ulven, Trond, Little, P. B., Nørregaard, P. K. & Högberg, T., 18 Oct 2004, In: Bioorganic & Medicinal Chemistry Letters. 14, 20, p. 5075-5080 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      4-Fluoro-N-methyl-N-(1,2,3,4-tetrahydrocarbazol-3-yl)benzenesulfonamide

      Rasmussen, K. G., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o742

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists

      Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists

      Ulven, Trond, Frimurer, Thomas Michael, Receveur, J., Little, P. B., Rist, Ø., Nørregaard, P. K. & Högberg, T., 2005, In: Journal of Medicinal Chemistry. 48, 18, p. 5684-5697 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

      Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, Trond, Milligan, G., Kenakin, T. & Kostenis, E., 17 Mar 2016, In: Cell Chemical Biology. 23, 3, p. 392-403 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

      Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      A concise synthesis of the potent inflammatory mediator 5-oxo-ETE

      Tyagi, R., Shimpukade, B., Blättermann, S., Kostenis, E. & Ulven, Trond, 2012, In: MedChemComm. 3, p. 195-198 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      A method for the selective hydrolysis of ketone hydrazones in the presence of acetals

      Ulven, Trond & Carlsen, P. H. J., 2000, In: European Journal of Organic Chemistry. 2000, 21, p. 3971-3972 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

      Petersen, T. P., Ritzén, A. & Ulven, Trond, 19 Nov 2009, In: Organic Letters. 11, 22, p. 5134-5137 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst

      Royer, J. F., Schratl, P., Lorenz, S., Kostenis, E., Ulven, Trond, Schuligoi, R., Peskar, B. A. & Heinemann, A., 1 Dec 2007, In: Allergy. 62, 12, p. 1401-1409 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      A physicogenetic method to assign ligand-binding relationships between 7TM receptors

      Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

      Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625

      Research output: Patent

    16. A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

      Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, Trond, Inoue, A., Hudson, B. D. & Milligan, G., 2017, In: Scientific Reports. 7, 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms

      Engel, D. F., Bobbo, V. C. D., Solon, C. S., Nogueira, G. A., Moura-Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, Trond & Velloso, L. A., 2020, In: Scientific Reports. 10, 1, 12 p., 11047.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans

      Sørensen, K. V., Korfitzen, S. S., Kaspersen, M. H., Ulven, Elisabeth Rexen, Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Clinical Nutrition. 40, 4, p. 2169-2179

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights

      Köse, M., Pillaiyar, T., Namasivayam, V., De Filippo, E., Sylvester, K., Ulven, Trond, Von Kügelgen, I. & Müller, C. E., 12 Mar 2020, In: Journal of Medicinal Chemistry. 63, 5, p. 2391-2410 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

      Uller, L., Mathiesen, Jesper M., Alenmyr, L., Korsgren, M., Ulven, Trond, Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 Feb 2007, In: Respiratory Research. 8, 16

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Antidiabetic enolic glucoside of phenylpyruvic acid.

      Joubert, E., Fey, S. J., Louw, J., Ulven, Trond & Tyagi, R., 12 Apr 2012, Patent No. WO 2012/045363A1

      Research output: Patent

    22. Published

      Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

      Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

      Theiler, A., Bärnthaler, T., Platzer, W., Richtig, G., Peinhaupt, M., Rittchen, S., Kargl, J., Ulven, Trond, Marsh, L. M., Marsche, G., Schuligoi, R., Sturm, E. M. & Heinemann, A., 2019, In: The Journal of allergy and clinical immunology. 144, 3, p. 764-776

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      CRTH2 receptor ligands for therapeutic use

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E., Högberg, T., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/115382 A1

      Research output: Patent

    25. Published

      CRTH2 receptor ligands for therapeutic use - B-series

      Ulven, Trond, Frimurer, Thomas Michael, Rist, Ø., Kostenis, E. & Högberg, T., 2005, Patent No. WO 2005/115374 A1

      Research output: Patent

    26. Published

      Characterising pharmacological ligands to study the long chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4

      Milligan, G., Alvarez-Curto, E., Watterson, K. R., Ulven, Trond & Hudson, B. D., 2015, In: British Journal of Pharmacology. 172, 13, p. 3254-3265 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues

      Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M., Li, J., D'Amico, G., Liotta, D., French, C. T., Wartmann, M., Altmann, K. H. & Giannakakou, P., 26 Sep 2001, In: American Chemical Society. Journal. 123, 38, p. 9313-9323 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

      Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

      Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Complex Pharmacology of Free Fatty Acid Receptors

      Milligan, G., Shimpukade, B., Ulven, Trond & Hudson, B. D., 11 Jan 2017, In: Chemical Reviews. 117, 1, p. 67-110 44 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

      Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Compounds for the treatment of metabolic diseases

      Ulven, Trond & Christiansen, E., 4 Feb 2010, Patent No. WO 2010/012650

      Research output: Patent

    33. Published

      Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MSALL

      Sokol, O., Ulven, Trond, Færgeman, N. J. & Ejsing, C. S., 2015, In: European Journal of Lipid Science and Technology. 117, 6, p. 751-759 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

      Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, Trond, Milligan, G. & Tobin, A. B., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18451-18465 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

      Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In: Journal of Biological Chemistry. 286, 14, p. 11890-11894 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

      Petersen, T. P., Larsen, A. F., Ritzén, A. & Ulven, Trond, 2013, In: Journal of Organic Chemistry. 78, 8, p. 4190-4195 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Controlled generation and use of CO in flow

      Hansen, S. V. F., Wilson, Z. E., Ulven, Trond & Ley, S. V., 2016, In: Reaction Chemistry & Engineering. 1, 3, p. 280-287 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Cyclic Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371

      Research output: Patent

    39. Published

      Cyclopropyl and cyclobutyl epothilone analogs

      Nicolaou, K. C., Namoto, K., Ritzén, A., Ulven, Trond, Shoji, M. & Altmann, K., 2009, Patent No. EP 1,420,780 B1

      Research output: Patent

    40. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

      Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands

      Nielsen, M. C., Borch, J. & Ulven, Trond, 15 Dec 2009, In: Bioorganic & Medicinal Chemistry. 17, 24, p. 8241-8246 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

      Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

      Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

      Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

      Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Direct N9-arylation of purines with aryl halides

      Larsen, A. F. & Ulven, Trond, 21 May 2014, In: Chemical Communications. 50, 39, p. 4997-4999 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Discovery and structure-activity relationship investigations of 4-arylethynyldihydrocinnamic acid agonists of the antidiabetic target free fatty acid receptor 1

      Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 2009.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    48. Published

      Discovery of GPR183 Agonists Based on an Antagonist Scaffold

      Kjær, Viktoria Madeline Skovgaard, Ieremias, L., Daugvilaite, V., Lückmann, Michael, Frimurer, Thomas Michael, Ulven, Trond, Rosenkilde, Mette & Våbenø, J., 2021, In: ChemMedChem. 16, 17, p. 2623-2627

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists

      Valentini, Alice, Schultz-Knudsen, Katrine, Hansen, A. H., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, Asmita, Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 9, p. 6105–6121

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Discovery of TUG-770

      Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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