Trond Ulven

Trond Ulven

Professor

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    ORCID: 0000-0002-8135-1755

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    1. Published

      Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

      Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      1,2-Dihydrospiro[carbazole-3(4H),2'-[1,3]dioxolane]

      Bjerrum, J. V., Ulven, Trond & Bond, A., 2009, In: Acta Crystallographica. Section E: Structure Reports Online. 65, p. o579

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

      Björkman, L., Mårtensson, J., Winther, M., Gabl, M., Holdfeldt, A., Uhrbom, M., Bylund, J., Højgaard Hansen, A., Pandey, S. K., Ulven, Trond, Forsman, H. & Dahlgren, C., 2016, In: Molecular and Cellular Biology. 36, 20, p. 2583-2595 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

      Blättermann, S., Peters, L., Ottersbach, P. A., Bock, A., Konya, V., Weaver, C. D., Gonzalez, A., Schröder, R., Tyagi, R., Luschnig, P., Gäb, J., Hennen, S., Ulven, Trond, Pardo, L., Mohr, K., Gütschow, M., Heinemann, A. & Kostenis, E., 2012, In: Nature Chemical Biology. 8, 7, p. 631-638 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Preparation of tetrahydroisoquinoline and tetrahydrobenzoazepine derivatives for use as GPR120 modulators.

      Brown, J., Connolly, S., Hansen, S. V. F., Milne, G., Shimpukade, B., Smyth, D., Thomas, G., Ulven, Trond, Brvar, M. & Rigby, A., 27 Sep 2018, Caldan Therapeutics Limited, UK ., Patent No. WO2018172727A1

      Research output: Patent

    6. Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

      Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, Trond, Milligan, G. & Tobin, A. B., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18451-18465 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Synthesis of benzylidene-protected dihydroxyacetone

      Carlsen, P. H. J., Sørbye, K. A., Ulven, Trond & Aasbø, K., 1996, In: Acta Chemica Scandinavica. 50, 2, p. 185-187 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

      Chalikiopoulos, A., Thiele, S., Malmgaard-Clausen, M., Rydberg, P., Isberg, V., Ulven, Trond, Frimurer, Thomas Michael, Rosenkilde, Mette & Gloriam, David E., 25 Nov 2013, In: Journal of Chemical Information and Modeling. 53, 11, p. 2863-73 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    10. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

      Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Discovery of TUG-770

      Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

      Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

      Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Discovery and structure-activity relationship investigations of 4-arylethynyldihydrocinnamic acid agonists of the antidiabetic target free fatty acid receptor 1

      Christiansen, E., Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 2009.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    17. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

      Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

      Deng, Y., Perez Almeria, C. V., van Gijzel, L., Schaller, Kay, Vedel, L., Gloriam, David E., Ulven, Trond & Bräuner, Hans, 2023, In: Basic and Clinical Pharmacology and Toxicology. 132, 6, p. 459-471

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

      Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

      Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

      Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, Claret, M., Velloso, L. A. & López, M., 2024, In: Molecular Metabolism. 79, 13 p., 101840.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

      Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms

      Engel, D. F., Bobbo, V. C. D., Solon, C. S., Nogueira, G. A., Moura-Assis, A., Mendes, N. F., Zanesco, A. M., Papangelis, A., Ulven, Trond & Velloso, L. A., 2020, In: Scientific Reports. 10, 1, 12 p., 11047.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Selective copper catalysed aromatic N-arylation in water

      Engel-Andreasen, J., Shimpukade, B. & Ulven, Trond, 2013, In: Green Chemistry. 15, 2, p. 336-340 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Quinazoline compounds and their use in MCH-related disease

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B., Receveur, J. & Grimstrup, M., 2005, Patent No. WO 2005/123714

      Research output: Patent

    26. Published

      A physicogenetic method to assign ligand-binding relationships between 7TM receptors

      Frimurer, Thomas Michael, Ulven, Trond, Elling, T. C. E., Gerlach, L. O., Kostenis, E. & Högberg, T., 2005, In: Bioorganic & Medicinal Chemistry Letters. 15, 16, p. 3707-3712 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625

      Research output: Patent

    28. Published

      Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052370

      Research output: Patent

    29. Published

      Cyclic Quinoline compounds for use in MCH receptor related disorders

      Frimurer, Thomas Michael, Ulven, Trond, Högberg, T., Nørregaard, P. K., Little, P. B. & Receveur, J., 2004, Patent No. WO 2004/052371

      Research output: Patent

    30. Published

      FFA1/Gq - Gi interaction determines glucose-induced insulin secretion of neonatal beta cells

      Gerst, F., Lorza-Gil, E., Kaiser, G., Ulven, Trond, Kostenis, E., Haring, H. -., Birkenfeld, A. L. & Ullrich, S., 2022, In: Diabetologia. 65, Suppl 1, p. S109-S109

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    31. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

      Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

      Gozal, D., Qiao, Z., Almendros, I., Zheng, J., Khalyfa, A., Shimpukade, B. & Ulven, Trond, 2016, In: International Journal of Obesity. 40, 7, p. 1143-1149 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

      Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

      Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, Trond, Milligan, G., Kenakin, T. & Kostenis, E., 17 Mar 2016, In: Cell Chemical Biology. 23, 3, p. 392-403 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Mucus can change the permeation rank order of drug candidates

      Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

      Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

      Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

      Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)

      Hansen, S. V. F. & Ulven, Trond, 2017, Free Fatty Acid Receptors. Springer Science+Business Media, p. 33-56 24 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    40. Published

      Oxalyl chloride as a practical carbon monoxide source for carbonylation reactions

      Hansen, S. V. F. & Ulven, Trond, 5 Jun 2015, In: Organic Letters. 17, 11, p. 2832-2835 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Controlled generation and use of CO in flow

      Hansen, S. V. F., Wilson, Z. E., Ulven, Trond & Ley, S. V., 2016, In: Reaction Chemistry & Engineering. 1, 3, p. 280-287 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

      Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

      Houthuijzen, J. M., Oosterom, I., Hudson, B. D., Hirasawa, A., Daenen, L. G. M., McLean, C. M., Hansen, S. V. F., van Jaarsveld, M. T. M., Peeper, D. S., Jafari Sadatmand, S., Roodhart, J. M. L., van de Lest, C. H. A., Ulven, Trond, Ishihara, K., Milligan, G. & Voest, E., 2017, In: F A S E B Journal. 31, 5, p. 2195-2209 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120)

      Hudson, B. D., Shimpukade, B., Milligan, G. & Ulven, Trond, 18 Jul 2014, In: Journal of Biological Chemistry. 289, 29, p. 20345-20358 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

      Hudson, B. D., Tikhonova, I. G., Pandey, S. K., Ulven, Trond & Milligan, G., 2012, In: Journal of Biological Chemistry. 287, 49, p. 41195-41209 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

      Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

      Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

      Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

      Hudson, B. D., Ulven, Trond & Milligan, G., 1 Jan 2013, In: Current Topics in Medicinal Chemistry. 13, 1, p. 14-25 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

      Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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