Blegdamsvej 3, 2200 København N, Bygning 6, Building: 06-1-10
Several complex biological molecular machineries exist that transfer molecules across lipid bilayers. In the group, we use a combination of cryo-electron microscopy and functional techniques to investigate the structure and mechanism of these systems. Of special interest to us are secretion systems of bacteria, which transfer protein molecules across the lipid bilayer, and contractile injection systems related to contractile bacteriophages which inject DNA and proteins into the cell. We also investigate human membrane transport proteins involved in health and disease.
Our overarching goal is to elucidate how transport across the membrane is achieved as well as regulated. We aim to uncover shared principles as well as fundamental differences between membrane transport systems and are especially interested in investigating these machineries in a near-native, lipid bilayer environment. Apart from gaining fundamental insight into transport across the membrane, our results can also aid structure-based drug design.