Klaus Bønnelykke
Clinical Professor
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High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial
Aagaard, K., Jepsen, J. R. M., Sevelsted, A., Horner, D., Vinding, R., Rosenberg, J. B., Brustad, N., Eliasen, A., Mohammadzadeh, P., Følsgaard, N., Hernández-lorca, M., Fagerlund, Birgitte, Glenthøj, Birte Yding, Rasmussen, Morten Arendt, Bilenberg, N., Stokholm, Jakob, Bønnelykke, Klaus, Ebdrup, Bjørn & Chawes, Bo Lund Krogsgaard, 2024, In: The American Journal of Clinical Nutrition. 119, 2, p. 362-370 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
U-BIOPRED Study Group, U. S. G., 2023, In: American Journal of Respiratory and Critical Care Medicine. 208, 2, p. 142-154 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, , 2020, In: Nature Communications. 11, 12 p., 6398.Research output: Contribution to journal › Journal article › Research › peer-review
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The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases
Alenius, H., Sinkko, H., Moitinho-Silva, L., Rodriguez, E., Broderick, C., Alexander, H., Reiger, M., Hjelmsø, M. H., Fyhrquist, N., Olah, P., Bryce, P., Smith, C., Koning, F., Eyerich, K., Greco, D., van den Bogaard, E. H., Neumann, A. U., Traidl-Hoffmann, C., Homey, B., Flohr, C. & 3 others, , 2021, In: Experimental Dermatology. 30, 10, p. 1517-1531Research output: Contribution to journal › Review › Research › peer-review
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GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
BIOS Consortium, B. C., Sebert, S., McCarthy, M. I., Järvelin, M. & Early Growth Genetics (EGG) Consortium, E. G. G. (. C., 2019, In: Science Advances. 5, 9, 18 p., eaaw3095.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term exposure to air pollution and asthma hospitalisations in older adults: a cohort study
Andersen, Zorana Jovanovic, Bønnelykke, Klaus, Hvidberg, M., Jensen, S. S., Ketzel, M., Loft, Steffen, Sørensen, M., Tjønneland, A., Overvad, K. & Raaschou-Nielsen, O., 2012, In: Thorax. 67, 1, p. 6-11 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sensitivity of multiple breath washout to detect mild-to-moderate asthma in adolescence
Arianto, L., Hallas, H. W., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2019, In: The Journal of Allergy and Clinical Immunology: In Practice. 7, 6, p. 2052-2054.e5Research output: Contribution to journal › Letter › Research › peer-review
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Multiple Breath Washout for Diagnosing Asthma and Persistent Wheeze in Young Children
Arianto, L., Hallas, H., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2019, In: American Thoracic Society. Annals (Print). 16, 5, p. 599-605 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, N., Jansen, R., de Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., Shen, X., Wilson, J. F., Chasman, D. I., Nolte, I. M., Tragante, V., van der Laan, S. W., Perry, J. R. B., Kong, A., Ahluwalia, T. V. S., Albrecht, E., Yerges-Armstrong, L., Atzmon, G., Auro, K., Ayers, K. & 31 others, , Dec 2016, In: Nature Genetics. 48, 12, p. 1462-1472 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Childhood asthma after bacterial colonization of the airway in neonates
Bisgaard, H., Hermansen, M. N., Buchvald, F., Loland, L., Halkjaer, L. B., Bønnelykke, K., Brasholt, M. S., Heltberg, A., Vissing, N. H., Thorsen, S. V., Stage, M., Pipper, C. B., Bisgaard, H., Hermansen, M. N., Buchvald, F., Loland, L., Halkjaer, L. B., Bønnelykke, K., Brasholt, M., Heltberg, A. & 4 others, , 11 Oct 2007, In: New England Journal of Medicine. 357, 15, p. 1487-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Asthma and neonatal airway colonization - Reply
Bisgaard, H., Bønnelykke, Klaus & Pipper, C., 24 Jan 2008, In: New England Journal of Medicine. 358, 4, p. 424-425Research output: Contribution to journal › Journal article › Research › peer-review
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Endotyping early childhood asthma by quantitative symptom assessment
Bisgaard, H., Pipper, C. B. & Bønnelykke, Klaus, 2011, In: Journal of Allergy and Clinical Immunology. 127, 5, p. 1155-1164 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Asthma-like symptoms in young children increase the risk of COPD
Bisgaard, H., Nørgaard, S., Sevelsted, A., Chawes, Bo Lund Krogsgaard, Stokholm, Jakob, Mortensen, Erik Lykke, Ulrik, Charlotte Suppli & Bønnelykke, Klaus, 2021, In: Journal of Allergy and Clinical Immunology. 147, 2, p. 569-576 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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25 Years of translational research in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC)
Bisgaard, H., Chawes, Bo Lund Krogsgaard, Stokholm, J., Mikkelsen, M., Schoos, Ann-Marie Malby & Bønnelykke, Klaus, 2023, In: Journal of Allergy and Clinical Immunology. 151, 3, p. 619-633 15 p.Research output: Contribution to journal › Review › Research › peer-review
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Long-term studies of the natural history of asthma in childhood
Bisgaard, H. & Bønnelykke, Klaus, 1 Aug 2010, In: Journal of Allergy and Clinical Immunology. 126, 2, p. 187-97; quiz 198-9Research output: Contribution to journal › Journal article › Research › peer-review
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Deep Phenotyping of the Unselected COPSAC2010 Birth Cohort Study
Bisgaard, H., Vissing, N. H., Carson, C. G., Bischoff, A. L., Følsgaard, N. V., Kreiner-Møller, E., Chawes, Bo Lund Krogsgaard, Stokholm, Jakob, Pedersen, L., Bjarnadóttir, E., Thysen, A. H., Nilsson, E., Mortensen, L. J., Olsen, Sjurdur F., Schjørring, S., Krogfelt, K. A., Lauritzen, Lotte, Pedersen, S. B. & Bønnelykke, Klaus, 2013, In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 43, 12, p. 1384–1394 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
Bisgaard, H., Hermansen, M. N., Bønnelykke, Klaus, Stokholm, Jakob, Baty, F., Skytt, N. L., Aniscenko, J., Kebadze, T. & Johnston, S. L., 2010, In: B M J. 341, 6 p., c4978.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction between asthma and lung function growth in early life
Bisgaard, H., Jensen, Signe Marie & Bønnelykke, Klaus, 2012, In: American Journal of Respiratory and Critical Care Medicine. 185, 11, p. 1183-1189 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fish Oil in Pregnancy and Asthma in Offspring: To the Editor
Bisgaard, H. & Bønnelykke, Klaus, 2017, In: New England Journal of Medicine. 376, 12, p. 1190-1192Research output: Contribution to journal › Comment/debate › Research
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Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood
Bisgaard, H., Bønnelykke, Klaus, Sleiman, P. M. A., Brasholt, M., Chawes, Bo Lund Krogsgaard, Kreiner-Møller, E., Stage, M., Kim, C., Tavendale, R., Baty, F., Pipper, C. B., Palmer, C. N. A. & Hakonarsson, H., 2009, In: American Journal of Respiratory and Critical Care Medicine. 179, 3, p. 179-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Childhood asthma after bacterial colonization of the airway in neonates
Bisgaard, H., Hermansen, M. N., Buchvald, F., Loland, L., Halkjaer, L. B., Bønnelykke, Klaus, Brasholt, M., Heltberg, Andreas Søndergaard, Vissing, N. H., Thorsen, S. V., Stage, M. & Pipper, C. B., 11 Oct 2007, In: The New England Journal of Medicine. 357, 15, p. 1487-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring
Bisgaard, H., Stokholm, Jakob, Chawes, B. L., Vissing, N. H., Bjarnadóttir, E., Schoos, A. M., Wolsk, H. M., Pedersen, T. M., Vinding, R. K., Thorsteinsdóttir, S., Følsgaard, N. V., Fink, N. R., Thorsen, Jonathan Jan Ilve, Pedersen, A. G., Waage, J., Rasmussen, Morten Arendt, Stark, K. D., Olsen, Sjurdur F. & Bønnelykke, Klaus, 29 Dec 2016, In: New England Journal of Medicine. 375, 26, p. 2530-2539 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure
Bisgaard, H., Simpson, A., Palmer, C. N. A., Bønnelykke, Klaus, McLean, I., Mukhopadhyay, S., Pipper, C. B., Halkjaer, L. B., Lipworth, B., Hankinson, J., Woodcock, A. & Custovic, A., 24 Jun 2008, In: P L o S Medicine (Print). 5, 6, p. e131Research output: Contribution to journal › Journal article › Research › peer-review
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Atopic and non-atopic effects of fish oil supplementation during pregnancy
Bisgaard, H., Mikkelsen, M., Rasmussen, Morten Arendt, Sevelsted, A., Schoos, Ann-Marie Malby, Brustad, N., Eliasen, A. U., Thorsen, J., Chawes, Bo Lund Krogsgaard, Gürdeniz, G., Morin, A., Stark, K., Stokholm, Jakob, Ober, C., Pedersen, C. E. T. & Bønnelykke, Klaus, 2023, In: Thorax. 78, 12, p. 1168–1174 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort
Bjarnadóttir, E., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Thorsen, Jonathan Jan Ilve, Mora-Jensen, A. R. C., Deleuran, M., Bønnelykke, Klaus, Lauritzen, Lotte & Bisgaard, H., 2019, In: Acta Paediatrica. 108, 9, p. 1632-1641 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Helgeland, O., Horikoshi, M., Karhunen, V., Lowry, E., Cousminer, D. L., Ahluwalia, T. S., Thiering, E., Boh, E. T-H., Zafarmand, M. H., Vilor-Tejedor, N., Wang, C. A., Joro, R., Chen, Z., Gauderman, W. J., Pitkanen, N., Parra, E. J. & 79 others, , 2019, In: Human Molecular Genetics. 28, 19, p. 3327-3338Research output: Contribution to journal › Journal article › Research › peer-review
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High-dose vitamin D supplementation in pregnancy and 25(OH)D sufficiency in childhood reduce the risk of fractures and improve bone mineralization in childhood: Follow-up of a randomized clinical trial
Brustad, N., Chawes, Bo Lund Krogsgaard, Thorsen, Jonathan Jan Ilve, Krakauer, M., Lasky-Su, J., Weiss, S. T., Stokholm, J., Bønnelykke, Klaus & Bisgaard, H., 2022, In: EClinicalMedicine. 43, 10 p., 101254.Research output: Contribution to journal › Journal article › Research › peer-review
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High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze
Brustad, N., Greve, J. H., Mirzakhani, H., Pedersen, C. T., Eliasen, A. U., Stokholm, Jakob, Lasky-Su, J., Bønnelykke, Klaus, Litonjua, A. A., Weiss, S. T., Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2021, In: Pediatric Allergy and Immunology. 32, 4, p. 679-689 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fish Oil and Vitamin D Supplementations in Pregnancy Protect Against Childhood Croup
Brustad, N., Yang, L., Chawes, Bo Lund Krogsgaard, Stokholm, J., Gürdeniz, G., Bønnelykke, Klaus & Bisgaard, H., 2023, In: Journal of Allergy and Clinical Immunology. 11, 1, p. 315-321Research output: Contribution to journal › Journal article › Research › peer-review
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Safety of High-Dose Vitamin D Supplementation among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis
Brustad, N., Yousef, S., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2022, In: JAMA network open. 5, 4, 14 p., E227410.Research output: Contribution to journal › Review › Research › peer-review
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Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial
Brustad, N., Garland, J., Thorsen, Jonathan Jan Ilve, Sevelsted, A., Krakauer, M., Vinding, R. K., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2020, In: JAMA Pediatrics. 174, 5, p. 419-427 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dietary prevention strategies for childhood asthma
Brustad, N., Bønnelykke, Klaus & Chawes, Bo Lund Krogsgaard, 2023, In: Pediatric Allergy and Immunology. 34, 7, 10 p., e13984.Research output: Contribution to journal › Review › Research › peer-review
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Diet-associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood
Brustad, N., Olarini, A., Kim, M., Chen, L., Ali, M., Wang, T., Cohen, A. S., Ernst, M., Hougaard, D., Schoos, Ann-Marie Malby, Stokholm, Jakob, Bønnelykke, Klaus, Lasky-Su, J., Rasmussen, Morten Arendt & Chawes, Bo Lund Krogsgaard, 2023, In: Pediatric Allergy and Immunology. 34, 2, 8 p., e13917.Research output: Contribution to journal › Journal article › Research › peer-review
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High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years
Brustad, N., Eliasen, A. U., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2019, In: J A M A: The Journal of the American Medical Association. 321, 10, p. 1003-1005Research output: Contribution to journal › Letter › Research › peer-review
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25-hydroxyvitamin D and risk of atopic diseases and infections in early childhood
Brustad, N., Kim, M., Skov, F., Schoos, Ann-Marie Malby, Stokholm, Jakob, Bønnelykke, Klaus & Chawes, Bo Lund Krogsgaard, 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78, 10, p. 2770-2773Research output: Contribution to journal › Comment/debate › Research › peer-review
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Associations of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life
Brustad, N., Fink, N. R., Stokholm, Jakob, Bønnelykke, Klaus, Følsgaard, N. V., Hougaard, D., Brix, S., Lasky-Su, J., Weiss, S. T. & Chawes, Bo Lund Krogsgaard, 2022, In: Nutrients. 14, 1, 9 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M. K., Shringarpure, S. S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B. M., Thomas, L. F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J. V. T., Bork-Jensen, J., Marenholz, I., Arnau-Soler, A. & 112 others, , 2023, In: Nature Communications. 14, 6172.Research output: Contribution to journal › Journal article › Research › peer-review
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A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways
Bustamante, M., Standl, M., Bassat, Q., Vilor-Tejedor, N., Medina-Gomez, C., Bonilla, C., Ahluwalia, T. V. S., Bacelis, J., Bradfield, J. P., Tiesler, C. M. T., Rivadeneira, F., Ring, S. M., Vissing, N. H., Fink, N. R., Jugessur, A., Mentch, F. D., Ballester, F., Kriebel, J., Kiefte-de Jong, J. C., Wolsk, H. M. & 19 others, , 2016, In: Human Molecular Genetics. 25, 18, p. 4127-4142Research output: Contribution to journal › Journal article › Research › peer-review
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Association between respiratory infections in early life and later asthma is independent of virus type
Bønnelykke, Klaus, Vissing, N. H., Sevelsted, A., Johnston, S. L. & Bisgaard, H., Jul 2015, In: The Journal of allergy and clinical immunology. 136, 1, p. 81-86.e4 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood
Bønnelykke, Klaus, Pipper, C. B. & Bisgaard, H., 1 Sep 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 657-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intrauterine and genetic factors in early childhood sensitization: A prospective cohort study of children at high risk of atopy
Bønnelykke, Klaus, Feb 2010, 62 p.Research output: Book/Report › Ph.D. thesis › Research
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Leveraging gene-environment interactions and endotypes for asthma gene discovery
Bønnelykke, Klaus & Ober, C., 2016, In: Journal of Allergy and Clinical Immunology. 137, 3, p. 667-679 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Postmenopausal hormone therapy and asthma-related hospital admission
Bønnelykke, Klaus, Raaschou-Nielsen, O., Tjønneland, Anne, Ulrik, Charlotte Suppli, Bisgaard, H. & Andersen, Zorana Jovanovic, Mar 2015, In: The Journal of allergy and clinical immunology. 135, 3, p. 813–816 4 p.Research output: Contribution to journal › Comment/debate › Research
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Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses
Bønnelykke, Klaus, Coleman, A. T., Evans, M. D., Thorsen, Jonathan Jan Ilve, Waage, J., Vissing, N. H., Carlsson, C. J., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Jessen, L. E., Fischer, T. K., Bochkov, Y. A., Ober, C., Lemanske, R. F., Jackson, D. J., Gern, J. E. & Bisgaard, H., 2018, In: American Journal of Respiratory and Critical Care Medicine. 197, 5, p. 589-594 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Astma hos børn
Bønnelykke, Klaus, Pedersen, S., Rubak, S. L. M., Schiøtz, O. & Bisgaard, H., 2013, In: Ugeskrift for Laeger. 175, 33, p. 1863-1867 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immune Mediator Levels in the Upper Airways Predict Response to Azithromycin for Episodes with Asthma-like Symptoms in Young Children
Carlsson, C. J., Rasmussen, Morten Arendt, Brix, S., Wang, N., Stokholm, J., Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus & Bisgaard, H., 2019, In: Pediatric Pulmonology. 54, S1, p. S75-S76 2 p., A-27.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Airway immune mediator levels during asthma-like symptoms in young children and their possible role in response to azithromycin
Carlsson, C. J., Rasmussen, Morten Arendt, Pedersen, S. B., Wang, N., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus & Bisgaard, H., 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 6, p. 1754-1764 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prenatal Vitamin D Supplementation to Improve Health in Offspring
Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus & Bisgaard, H., 2018, In: JAMA Pediatrics. 172, 7, p. 617-618 2 p.Research output: Contribution to journal › Editorial › Research
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Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze
Chawes, Bo Lund Krogsgaard, Buchvald, F., Bischoff, A. L., Loland, L., Hermansen, M., Halkjaer, L. B., Bønnelykke, Klaus & Bisgaard, H., 15 Jul 2010, In: American Journal of Respiratory and Critical Care Medicine. 182, 2, p. 138-42 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel method for assessing unchallenged levels of mediators in nasal epithelial lining fluid
Chawes, Bo Lund Krogsgaard, Edwards, M. J., Shamji, B., Walker, C., Nicholson, G. C., Tan, A. J., Følsgaard, N. V., Bønnelykke, Klaus, Bisgaard, H. & Hansel, T. T., 1 Jun 2010, In: Journal of Allergy and Clinical Immunology. 125, 6, p. 1387-1389.e3Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1504169
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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
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Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
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Maturation of the gut microbiome and risk of asthma in childhood
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