Kei Sakamoto
Professor
Sakamoto Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- 1996
Creatine kinase release from regenerated muscles after eccentric contractions in rats
Sakamoto, Kei, Nosaka, K., Shimegi, S., Ohmori, H. & Katsuta , S., 1 Jan 1996, In: European Journal of Applied Physiology and Occupational Physiology. 73, 6, p. 516-520 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
Loss of sarcoplasmic reticulum membrane integrity after eccentric contractions
Yasuda, T., Sakamoto, Kei, Nosaka, K., Wada, M. & Katsuta, S., 1 Jan 1997, p. 581-582. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research
- 1998
Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study
Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M. & Sakamoto, Kei, 1 Jan 1998, In: Acta Neuropathologica. 95, 2, p. 123-130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles
Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, Kei & Totsuka, T., 5 Aug 1999, In: Biochimica et Biophysica Acta - General Subjects. 1428, 2-3, p. 284-292 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Changes in plasma enzyme activity after intramuscular injection of bupivacaine into the human biceps brachii
Nosaka, K. & Sakamoto, Kei, 1 Dec 1999, In: Acta Physiologica Scandinavica. 167, 3, p. 259-265 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats
Sakuma, K., Watanabe, K., Sano, M., Kitajima, S., Sakamoto, Kei, Uramoto, I. & Totsuka, T., Feb 2000, In: Acta Neuropathologica. 99, 2, p. 177-185 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Changes in Leukocytes after Eccentric Exerclse ot the Elbow Flexors
Nosaka, K. & Sakamoto, Kei, 25 May 2000, In: Advances in Exercise and Sports Physiology. 6, 2, p. 59-65 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise
Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors
Nosaka, K. & Sakamoto, Kei, 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 1, p. 22-29 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
How long does the protective effect on eccentric exercise-induced muscle damage last?
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 9, p. 1490-1495 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: European Journal of Applied Physiology. 85, 1-2, p. 34-40 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle
Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358Research output: Contribution to journal › Journal article › Research › peer-review
Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line
Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Effect of AICAR treatment on glycogen metabolism in skeletal muscle
Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Invited review: Intracellular signaling in contracting skeletal muscle
Sakamoto, Kei & Goodyear, L. J., 1 Jan 2002, In: Journal of Applied Physiology. 93, 1, p. 369-383 15 p.Research output: Contribution to journal › Review › Research › peer-review
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, Kei, Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C. & Ronald Kahn, C., 1 Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 141-149 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Influence of Arm-cranking on Changes in Plasma CK Activity after High Force Eccentric Exercise of the Elbow Flexors
Nosaka, K., Sakamoto, Kei & Newton, M., 25 Mar 2002, In: Advances in Exercise and Sports Physiology. 8, 2, p. 45-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Contraction regulation of Akt in rat skeletal muscle
Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G. & Goodyear, L. J., 5 Apr 2002, In: Journal of Biological Chemistry. 277, 14, p. 11910-11917 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice
Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
Stoppani, J., Hildebrandt, A. L., Sakamoto, Kei, Cameron-Smith, D., Goodyear, L. J. & Darrell Neufer, P., 1 Dec 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 283, 6 46-6, p. E1239-E1248Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Akt signaling in skeletal muscle: Regulation by exercise and passive stretch
Sakamoto, Kei, Aschenbach, W. G., Hirshman, M. F. & Goodyear, L. J., 1 Nov 2003, In: American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1081-E1088Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise
Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.Research output: Contribution to journal › Review › Research › peer-review
Influence of pre-exercise muscle temperature on responses to eccentric exercise
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Apr 2004, In: Journal of Athletic Training. 39, 2, p. 132-137 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle
Sakamoto, Kei, Arnolds, D. E. W., Ekberg, I., Thorell, A. & Goodyear, L. J., 25 Jun 2004, In: Biochemical and Biophysical Research Communications. 319, 2, p. 419-425 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208Research output: Contribution to journal › Journal article › Research › peer-review
Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR
Sakamoto, Kei, Göransson, O., Hardie, D. G. & Alessi, D. R., 1 Aug 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E310-E317Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, Kei, Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R., 20 Apr 2005, In: EMBO Journal. 24, 8, p. 1571-1583 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Sakamoto, Kei, McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R., 18 May 2005, In: EMBO Journal. 24, 10, p. 1810-1820 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
Mora, A., Sakamoto, Kei, McManus, E. J. & Alessi, D. R., 27 Jul 2005, In: FEBS Letters. 579, 17, p. 3632-3638 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle
Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, Kei, Hajduch, E., Arthur, J. S. C. & Hundal, H. S., 1 Nov 2005, In: Diabetes. 54, 11, p. 3161-3168 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
AMPK: A key sensor of fuel and energy status in skeletal muscle
Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.Research output: Contribution to journal › Review › Research › peer-review
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
Sakamoto, Kei, Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanović, A., Alessi, D. R. & Bertrand, L., 1 May 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 290, 5, p. E780-E788Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle
Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, Kei, Hirshman, M. F. & Goodyear, L. J., 1 Jul 2006, In: Diabetes. 55, 7, p. 2067-2076 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway
Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158Research output: Contribution to journal › Journal article › Research › peer-review
LKB1-dependent signaling pathways
Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.Research output: Contribution to journal › Review › Research › peer-review
Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise
Howlett, K. F., Sakamoto, Kei, Yu, H., Goodyear, L. J. & Hargreaves, M., 1 Aug 2006, In: Metabolism: Clinical and Experimental. 55, 8, p. 1046-1052 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Evaluation of approaches to generation of tissue-specific knock-in mice
Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle
Sakamoto, Kei, Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F. & Goodyear, L. J., 24 Nov 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 5, p. E1031-E1037Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels
Sukhodub, A., Jovanović, S., Qingyou, D. U., Budas, G., Clelland, A. K., Shen, M. E. I., Sakamoto, Kei, Tian, R. & Jovanović, A., 1 Jan 2007, In: Journal of Cellular Physiology. 210, 1, p. 224-236 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study
Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., Sakamoto, Kei & Musi, N., 1 Mar 2007, In: Diabetes. 56, 3, p. 836-848 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle
Howlett, K. F., Sakamoto, Kei, Garnham, A., Cameron-Smith, D. & Hargreaves, M., 1 Jun 2007, In: Diabetes. 56, 6, p. 1608-1614 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle
Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35Research output: Contribution to journal › Journal article › Research › peer-review
Silencing Metabolic Disorders by Novel SIRT1 Activators
Sakamoto, Kei, 9 Jan 2008, In: Cell Metabolism. 7, 1, p. 3-4 2 p.Research output: Contribution to journal › Letter › Research › peer-review
The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle
Howlett, K. F., Mathews, A., Garnham, A. & Sakamoto, Kei, 1 Feb 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 2, p. E401-E407Research output: Contribution to journal › Journal article › Research › peer-review
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle
Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, Kei & Kawanaka, K., 1 Jun 2008, In: Metabolism: Clinical and Experimental. 57, 6, p. 749-756 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Huang, X., Wullschleger, S., Shpiro, M., McGuire, V. A., Sakamoto, Kei, Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 211-221 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
Sakamoto, Kei & Holman, G. D., 1 Jul 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 1, p. E29-E37Research output: Contribution to journal › Review › Research › peer-review
ID: 227976158
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Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle
Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates
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Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Research output: Contribution to journal › Journal article › Research › peer-review
Published