Kei Sakamoto

Kei Sakamoto

Professor

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    Publication year:
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    1 - 100 out of 145Page size: 100
    1. 1996

    2. Creatine kinase release from regenerated muscles after eccentric contractions in rats

      Sakamoto, Kei, Nosaka, K., Shimegi, S., Ohmori, H. & Katsuta , S., 1 Jan 1996, In: European Journal of Applied Physiology and Occupational Physiology. 73, 6, p. 516-520 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 1997

    4. Loss of sarcoplasmic reticulum membrane integrity after eccentric contractions

      Yasuda, T., Sakamoto, Kei, Nosaka, K., Wada, M. & Katsuta, S., 1 Jan 1997, p. 581-582. 2 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    5. 1998

    6. Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study

      Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M. & Sakamoto, Kei, 1 Jan 1998, In: Acta Neuropathologica. 95, 2, p. 123-130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. 1999

    8. The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

      Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, Kei & Totsuka, T., 5 Aug 1999, In: Biochimica et Biophysica Acta - General Subjects. 1428, 2-3, p. 284-292 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Changes in plasma enzyme activity after intramuscular injection of bupivacaine into the human biceps brachii

      Nosaka, K. & Sakamoto, Kei, 1 Dec 1999, In: Acta Physiologica Scandinavica. 167, 3, p. 259-265 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2000

    11. The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats

      Sakuma, K., Watanabe, K., Sano, M., Kitajima, S., Sakamoto, Kei, Uramoto, I. & Totsuka, T., Feb 2000, In: Acta Neuropathologica. 99, 2, p. 177-185 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Changes in Leukocytes after Eccentric Exerclse ot the Elbow Flexors

      Nosaka, K. & Sakamoto, Kei, 25 May 2000, In: Advances in Exercise and Sports Physiology. 6, 2, p. 59-65 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. 2001
    14. Published

      The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

      Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors

      Nosaka, K. & Sakamoto, Kei, 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 1, p. 22-29 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. How long does the protective effect on eccentric exercise-induced muscle damage last?

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 9, p. 1490-1495 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: European Journal of Applied Physiology. 85, 1-2, p. 34-40 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle

      Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

      Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2002

    21. Effect of AICAR treatment on glycogen metabolism in skeletal muscle

      Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Invited review: Intracellular signaling in contracting skeletal muscle

      Sakamoto, Kei & Goodyear, L. J., 1 Jan 2002, In: Journal of Applied Physiology. 93, 1, p. 369-383 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

      Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, Kei, Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C. & Ronald Kahn, C., 1 Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 141-149 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Influence of Arm-cranking on Changes in Plasma CK Activity after High Force Eccentric Exercise of the Elbow Flexors

      Nosaka, K., Sakamoto, Kei & Newton, M., 25 Mar 2002, In: Advances in Exercise and Sports Physiology. 8, 2, p. 45-50 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Contraction regulation of Akt in rat skeletal muscle

      Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G. & Goodyear, L. J., 5 Apr 2002, In: Journal of Biological Chemistry. 277, 14, p. 11910-11917 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

      Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle

      Stoppani, J., Hildebrandt, A. L., Sakamoto, Kei, Cameron-Smith, D., Goodyear, L. J. & Darrell Neufer, P., 1 Dec 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 283, 6 46-6, p. E1239-E1248

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. 2003

    29. Akt signaling in skeletal muscle: Regulation by exercise and passive stretch

      Sakamoto, Kei, Aschenbach, W. G., Hirshman, M. F. & Goodyear, L. J., 1 Nov 2003, In: American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1081-E1088

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2004

    31. 5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise

      Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    32. Influence of pre-exercise muscle temperature on responses to eccentric exercise

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Apr 2004, In: Journal of Athletic Training. 39, 2, p. 132-137 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle

      Sakamoto, Kei, Arnolds, D. E. W., Ekberg, I., Thorell, A. & Goodyear, L. J., 25 Jun 2004, In: Biochemical and Biophysical Research Communications. 319, 2, p. 419-425 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

      Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR

      Sakamoto, Kei, Göransson, O., Hardie, D. G. & Alessi, D. R., 1 Aug 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E310-E317

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2005

    37. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

      McManus, E. J., Sakamoto, Kei, Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R., 20 Apr 2005, In: EMBO Journal. 24, 8, p. 1571-1583 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

      Sakamoto, Kei, McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R., 18 May 2005, In: EMBO Journal. 24, 10, p. 1810-1820 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart

      Mora, A., Sakamoto, Kei, McManus, E. J. & Alessi, D. R., 27 Jul 2005, In: FEBS Letters. 579, 17, p. 3632-3638 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

      Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, Kei, Hajduch, E., Arthur, J. S. C. & Hundal, H. S., 1 Nov 2005, In: Diabetes. 54, 11, p. 3161-3168 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. 2006

    42. AMPK: A key sensor of fuel and energy status in skeletal muscle

      Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    43. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

      Sakamoto, Kei, Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanović, A., Alessi, D. R. & Bertrand, L., 1 May 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 290, 5, p. E780-E788

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle

      Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, Kei, Hirshman, M. F. & Goodyear, L. J., 1 Jul 2006, In: Diabetes. 55, 7, p. 2067-2076 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway

      Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. LKB1-dependent signaling pathways

      Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    47. Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise

      Howlett, K. F., Sakamoto, Kei, Yu, H., Goodyear, L. J. & Hargreaves, M., 1 Aug 2006, In: Metabolism: Clinical and Experimental. 55, 8, p. 1046-1052 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Evaluation of approaches to generation of tissue-specific knock-in mice

      Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

      Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle

      Sakamoto, Kei, Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F. & Goodyear, L. J., 24 Nov 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 5, p. E1031-E1037

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2007

    52. AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels

      Sukhodub, A., Jovanović, S., Qingyou, D. U., Budas, G., Clelland, A. K., Shen, M. E. I., Sakamoto, Kei, Tian, R. & Jovanović, A., 1 Jan 2007, In: Journal of Cellular Physiology. 210, 1, p. 224-236 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study

      Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., Sakamoto, Kei & Musi, N., 1 Mar 2007, In: Diabetes. 56, 3, p. 836-848 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

      Howlett, K. F., Sakamoto, Kei, Garnham, A., Cameron-Smith, D. & Hargreaves, M., 1 Jun 2007, In: Diabetes. 56, 6, p. 1608-1614 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

      Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. 2008
    57. Published

      Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

      Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Silencing Metabolic Disorders by Novel SIRT1 Activators

      Sakamoto, Kei, 9 Jan 2008, In: Cell Metabolism. 7, 1, p. 3-4 2 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    59. The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle

      Howlett, K. F., Mathews, A., Garnham, A. & Sakamoto, Kei, 1 Feb 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 2, p. E401-E407

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

      Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle

      Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, Kei & Kawanaka, K., 1 Jun 2008, In: Metabolism: Clinical and Experimental. 57, 6, p. 749-756 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

      Huang, X., Wullschleger, S., Shpiro, M., McGuire, V. A., Sakamoto, Kei, Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 211-221 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

      Sakamoto, Kei & Holman, G. D., 1 Jul 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 1, p. E29-E37

      Research output: Contribution to journal › Review › Research › peer-review

    64. Published

      Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

      Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, Kei & Hundal, H. S., 10 Oct 2008, In: Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Regulating the Motor for GLUT4 Vesicle Traffic

      Holman, G. D. & Sakamoto, Kei, 5 Nov 2008, In: Cell Metabolism. 8, 5, p. 344-346 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    66. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

      Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, Kei & Hardie, D. G., 15 Nov 2008, In: Biochemical Journal. 416, 1, p. 1-14 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. 2009
    68. Published

      Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy

      Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, Kei, Foretz, M. & Viollet, B., Jul 2009, In: FASEB Journal. 23, 7, p. 2264-2273 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

      Guigas, B., Sakamoto, Kei, Taleux, N., Reyna, S. M., Musi, N., Viollet, B. & Hue, L., 1 Dec 2009, In: IUBMB Life. 61, 1, p. 18-26 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    70. 2010
    71. Published

      Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

      Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, Kei, Andreelli, F. & Viollet, B., 1 Jul 2010, In: Journal of Clinical Investigation. 120, 7, p. 2355-2369 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle

      Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., Van Diepen, J. A., Voshol, P. J., Jensen, J. & Sakamoto, Kei, 3 Nov 2010, In: Cell Metabolism. 12, 5, p. 456-466 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. 2011
    74. Published

      Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

      Hunter, R. W., Treebak, Jonas Thue, Wojtaszewski, Jørgen F P & Sakamoto, Kei, 2011, In: Diabetes. 60, 3, p. 766-774 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes

      Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

      Wullschleger, S., Sakamoto, Kei, Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., 1 Jan 2011, In: DMM Disease Models and Mechanisms. 4, 1, p. 95-103 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking

      Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, Kei, 5 Jan 2011, In: Cell Metabolism. 13, 1, p. 68-79 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

      Richardson, C., Sakamoto, Kei, De Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In: Journal of Cell Science. 124, 5, p. 789-800 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P2 in regulating insulin sensitivity defined by knock-in analysis

      Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, Kei & Alessi, D. R., 1 Mar 2011, In: Biochemical Journal. 434, 2, p. 265-274 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

      Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, Kei & Hundal, H. S., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 463-474 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Protor-1 is required for efticient mT0RC2-mediated activation of SGK1 in the kidney

      Pearce, L. R., Sommer, E. M., Sakamoto, Kei, Wullschleger, S. & Alessi, D. R., 15 May 2011, In: Biochemical Journal. 436, 1, p. 169-179 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury

      Kim, A. S., Miller, E. J., Wright, T. M., Li, J., Qi, D., Atsina, K., Zaha, V., Sakamoto, Kei & Young, L. H., 1 Jul 2011, In: Journal of Molecular and Cellular Cardiology. 51, 1, p. 24-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

      Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P. P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, Kei, Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. & Brunet, A., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 878-892 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. 2012

    85. Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

      Joanne, P., Hourdé, C., Ochala, J., Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamoto, Kei, Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 2012, In: PLoS ONE. 7, 4, p. e35346

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

      Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, Kei, Hue, L. & Rider, M. H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 193-203 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Thr 649 Ala-AS160 knock-in mutation does not impair contraction/ AICAR-induced glucose transport in mouse muscle

      Ducommun, S., Wang, H. Y., Sakamoto, Kei, MacKintosh, C. & Chen, S., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1036-E1043

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. The ancient drug salicylate directly activates AMP-activated protein kinase

      Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, Kei, Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

      Din, F. V. N., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, Kei, Alessi, D. R. & Dunlop, M. G., Jun 2012, In: Gastroenterology. 142, 7, p. 1504-1515.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Cellular responses to the metal-binding properties of metformin

      Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, Kei, Prescott, A. R. & Rena, G., 1 Jun 2012, In: Diabetes. 61, 6, p. 1423-1433 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes

      Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, Kei & Göransson, O., 15 Jun 2012, In: Biochemical Journal. 444, 3, p. 503-514 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

      Jensen, J., Tantiwong, P., Stuenæs, J. T., Molina-Carrion, M., de Fronzo, R. A., Sakamoto, Kei & Musi, N., 1 Jul 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 1, p. E82-E89

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

      Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E. & Sakamoto, Kei, 1 Nov 2012, In: Cellular Signalling. 24, 11, p. 2085-2094 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

      Li, M., Verdijk, L. B., Sakamoto, Kei, Ely, B., van Loon, L. J. C. & Musi, N., 1 Nov 2012, In: Mechanisms of Ageing and Development. 133, 11-12, p. 655-664 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. 2013
    96. Published

      LKB1 regulates lipid oxidation during exercise independently of AMPK

      Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, Andreas Mæchel, Pehmøller, C., Sylow, Lykke, Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, Clara, Qvortrup, Klaus, Dyck, J. R. B., Hunter, R. W., Sakamoto, Kei, Thomson, D. M., Schjerling, Peter, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

      Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, Kei, Mackintosh, C. & Chen, S., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 479-489 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin α∥bβ3 activation and granule secretion in platelets

      Moore, S. F., Van Den Bosch, M. T. J., Hunter, R. W., Sakamoto, Kei, Poole, A. W. & Hers, I., 8 Feb 2013, In: Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition

      Wan, M., Leavens, K. F., Hunter, R. W., Koren, S., Von Wilamowitz-Moellendorff, A., Lu, M., Satapati, S., Chu, Q., Sakamoto, Kei, Burgess, S. C. & Birnbaum, M. J., 2 Jul 2013, In: Cell Metabolism. 18, 1, p. 99-105 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

      Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, Kei, Foretz, M., Viollet, B. & Chazaud, B., 6 Aug 2013, In: Cell Metabolism. 18, 2, p. 251-264 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    101. Molecular mechanism of action of metformin: Old or new insights?

      Rena, G., Pearson, E. R. & Sakamoto, Kei, 1 Sep 2013, In: Diabetologia. 56, 9, p. 1898-1906 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    102. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

      Von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, Kei, 1 Dec 2013, In: Diabetes. 62, 12, p. 4070-4082 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    103. 2014

    104. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells

      De Meester, C., Timmermans, A. D., Balteau, M., Ginion, A., Roelants, V., Noppe, G., Porporato, P. E., Sonveaux, P., Viollet, B., Sakamoto, Kei, Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & Bertrand, L., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 20-29 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    105. Salicylic acid: old and new implications for the treatment of type 2 diabetes?

      Rena, G. & Sakamoto, Kei, 1 Jan 2014, In: Diabetology International. 5, 4, p. 212-218 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    106. Investigation of LKB1 Ser431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

      Houde, V. P., Ritorto, M. S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, Kei & Alessi, D. R., 15 Jan 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    107. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

      Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y. Y., Kolwicz, S. C., Xu, J., Sakamoto, Kei, Wang, W. & Tian, R., 14 Mar 2014, In: Circulation Research. 114, 6, p. 966-975 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    108. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

      Ducommun, S., Ford, R. J., Bultot, L., Deak, M., Bertrand, L., Kemp, B. E., Steinberg, G. R. & Sakamoto, Kei, 15 Mar 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 6, p. E688-E696

      Research output: Contribution to journal › Journal article › Research › peer-review

    109. The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets

      Onselaer, M. B., Oury, C., Hunter, R. W., Eeckhoudt, S., Barile, N., Lecut, C., Morel, N., Viollet, B., Jacquet, L. M., Bertrand, L., Sakamoto, Kei, Vanoverschelde, J. L., Beauloye, C. & Horman, S., Jun 2014, In: Journal of Thrombosis and Haemostasis. 12, 6, p. 973-986 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    110. A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

      Timmermans, A. D., Balteau, M., Gélinas, R., Renguet, E., Ginion, A., de Meester, C., Sakamoto, Kei, Balligand, J. L., Bontemps, F., Vanoverschelde, J. L., Horman, S., Beauloye, C. & Bertrand, L., 15 Jun 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 306, 12, p. H1619-H1630

      Research output: Contribution to journal › Journal article › Research › peer-review

    111. Structural basis for the recruitment of glycogen synthase by glycogenin

      Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, Kei & Sicheri, F., 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840

      Research output: Contribution to journal › Journal article › Research › peer-review

    112. Mechanism of action of compound-13: An α1-selective small molecule activator of AMPK

      Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, Kei, 17 Jul 2014, In: Chemistry and Biology. 21, 7, p. 866-879 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    113. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

      Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, Kei, 4 Aug 2014, In: Nature Communications. 5, 4535.

      Research output: Contribution to journal › Journal article › Research › peer-review

    114. 2015
    115. Published

      SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

      Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, Andreas Mæchel, Foretz, M., Campbell, D. G., Sakamoto, Kei, Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    116. Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

      Hunter, R. W., Zeqiraj, E., Morrice, N., Sicheri, F. & Sakamoto, Kei, Apr 2015, In: Protein Expression and Purification. 108, p. 23-29 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    117. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

      Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    118. Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16

      Shehata, S. N., Deak, M., Morrice, N. A., Ohta, E., Hunter, R. W., Kalscheuer, V. M. & Sakamoto, Kei, 1 Aug 2015, In: Biochemical Journal. 469, 3, p. 409-420 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    119. 2016
    120. Published

      Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

      Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    121. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

      Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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