Kasper Harpsøe

Kasper Harpsøe

Research consultant

ORCID: 0000-0002-9326-9644

Current position:

11/2021 - : Research Consultant / Data and Computing Facility Manager, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

Previous employments:

01/2020 - 10/2021: Senior Advisor / Senior Computational Chemist, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

09/2015 - 12/2019 : Academic Staff / Coputational Chemist, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

01/2014 - 08/2015 : Post doc, Department of Drug Design and Pharmacology, Faculty of Health and Medical Scineces

03/2012 - 12/2013: Post doc, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Scineces

11/2011 – 02/2012: Postdoc, Faculty of Pharmaceutical Sciences, University of Copenhagen

12/2007 - 06/2011: Postdoc, Faculty of Pharmaceutical Sciences, University of Copenhagen

07/2007 – 11/2007: Scientific Assistant, Faculty of Pharmaceutical Sciences, University of Copenhagen

07/2006 – 06/2007: Research Scientist (Post Doc.), Arpida A/S, Department of Structural Chemistry

05/2006 – 06/2006: Scientific Assistant, The Danish University of Pharmaceutical Sciences 

05/2003 – 04/2006: Ph.D. Student, The Danish University of Pharmaceutical Sciences (including three months traineeship at Schrödinger Inc. New York)

02/2002 – 04/2003: Clinical Research Associate, Quintiles AB

11/2001 – 01/2002: Pharmacist (temporary position), The Danish Medicines Agency, Department of Clinical Trials.

Education:

2006: Ph.D., The Danish University of Pharmaceutical Sciences
Title: Computational Studies on Allosteric Modulations of Ionotropic Glutamate Receptors
2001: Master of Science in pharmacy (Cand. Pharm.), The Royal Danish School of Pharmacy
Masters thesis title: Evaluation of MultiSelect and MultiScore - An Evaluation of New Procedures for Predicting Binding Conformation and Binding Affinity

Research expertises:

  • Structure-based design of peptide and small molecule ligands
  • Binding site identification and characterization
  • Docking and binding pose evaluation
  • Protein-ligand interactions 
  • Conformational analysis 
  • QSAR
  • Sequence analysis
  • Homology modeling
  • Molecular dynamics
  • Prediction of protein-ligand binding energy
  • Quantum Chemistry calculations

International experience:

2005 - Three month as trainee at Schrödinger.
Performed a validation project on Liaison and gained general experience with the Schrödinger molecular modeling software suite; especially with the extra options and setting available through the command line utilities.

2008 - Two weeks stay with the Carlson research group at University of Michigan.
Gained hands-on experience with setting up Molecular dynamics calculations of large protein-ligand complexes.

 

Education

Ph.D. and M.Sc. Pharm.

ID: 1428429