Jesper M. Mathiesen
Associate Professor
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
- 2024
- Published
A µ-opioid receptor modulator that works cooperatively with naloxone
O’Brien, E. S., Rangari, V. A., El Daibani, A., Eans, S. O., Hammond, H. R., White, E., Wang, H., Shiimura, Y., Krishna Kumar, K., Jiang, Q., Appourchaux, K., Huang, W., Zhang, C., Kennedy, B. J., Mathiesen, Jesper M., Che, T., McLaughlin, J. P., Majumdar, S. & Kobilka, B. K., 2024, In: Nature. 631, 8021, p. 686-693Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
He, F., Wu, C. G., Gao, Y., Rahman, Sabrina Nalini, Zaoralová, M., Papasergi-Scott, M. M., Gu, T. J., Robertson, M. J., Seven, A. B., Li, L., Mathiesen, Jesper M. & Skiniotis, G., 2024, In: Nature. 626, p. 1141–1148Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bitopic Ligands Support the Presence of a Metastable Binding Site at the β2 Adrenergic Receptor
Gaiser, B. I., Danielsen, Mia, Xu, X., Røpke Jørgensen, K., Fronik, P., Marcher, Emil, Wróbel, T. M., Liu, X., Mathiesen, Jesper M. & Sejer Pedersen, D., 2024, In: Journal of Medicinal Chemistry. 67, 13, p. 11053–11068Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor
Batebi, H., Pérez-Hernández, G., Rahman, Sabrina Nalini, Lan, B., Kamprad, A., Shi, M., Speck, D., Tiemann, Johanna Katarina Sofie, Guixà-González, R., Reinhardt, F., Stadler, P. F., Papasergi-Scott, M. M., Skiniotis, G., Scheerer, P., Kobilka, B. K., Mathiesen, Jesper M., Liu, X. & Hildebrand, P. W., 2024, (Accepted/In press) In: Nature Structural and Molecular Biology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Glycine: a long-sought novel ligand for GPR158
Rosenkilde, Mette & Mathiesen, Jesper M., 2023, In: Trends in Pharmacological Sciences. 44, 8, p. 489-491Research output: Contribution to journal › Letter › Research › peer-review
- 2022
- Published
Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells
Deng, Y., Moo, Ee Von, Almería, C. V. P., Gentry, P. R., Vedel, L., Mathiesen, Jesper M. & Bräuner, Hans, 2022, In: Basic and Clinical Pharmacology and Toxicology. 131, 2, p. 104-113Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Asymmetric activation of the calcium-sensing receptor homodimer
Gao, Y., Robertson, M. J., Rahman, Sabrina Nalini, Seven, A. B., Zhang, C., Meyerowitz, J. G., Panova, O., Hannan, F. M., Thakker, R. V., Bräuner, Hans, Mathiesen, Jesper M. & Skiniotis, G., 2021, In: Nature. 595, p. 455-459Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G-protein activation by a metabotropic glutamate receptor
Seven, A. B., Barros-Álvarez, X., de Lapeyrière, M., Papasergi-Scott, M. M., Robertson, M. J., Zhang, C., Nwokonko, R. M., Gao, Y., Meyerowitz, J. G., Rocher, J. P., Schelshorn, D., Kobilka, B. K., Mathiesen, Jesper M. & Skiniotis, G., 2021, In: Nature. 595, p. 450-454Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs
Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner, Hans, 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
Møller, T. C., Pedersen, M. F., van Senten, Jeffrey Roy, Seiersen, S. D., Mathiesen, Jesper M., Bouvier, M. & Bräuner, Hans, 2020, In: Scientific Reports. 10, 1, 13 p., 17395.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4873159
Most downloads
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167
downloads
Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
45
downloads
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
31
downloads
Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published