Helle S. Waagepetersen

Helle S. Waagepetersen

Guest Researcher


  1. 2010
  2. Published

    A functioning glycolysis is important for maintenance of glutamate transport in cultured astrocytes

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Bouman, S. D. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. s1, p. 288-289

    Research output: Contribution to journalConference abstract in journalResearch

  3. Published

    Characterization of primary and secondary cultures of astrocytes prepared from mouse cerebral cortex

    Jensen, Dorte Skytt, Madsen, K. K., Pajecka, K., Schousboe, Arne & Waagepetersen, Helle S., 2010, In: Neurochemical Research. 35, 12, p. 2043-2052 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  5. Published

    Functional importance of the astrocytic glycogen-shunt and glycolysis for maintenance of an intact intra/extracellular glutamate gradient

    Schousboe, Arne, Sickmann, H. M., Walls, Anne Byriel, Bak, Lasse Kristoffer & Waagepetersen, Helle S., 2010, In: Neurotoxicity Research. 18, 1, p. 94-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    GABA-syntese - en vigtig brik for kontrol af epilepsi

    Walls, Anne Byriel, Schousboe, Arne & Waagepetersen, Helle S., 2010, In: Lægemiddelforskning. 2010, p. 31-33

    Research output: Contribution to journalJournal articleCommunication

  7. Published

    GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

    Walls, Anne Byriel, Nilsen, L. H., Eyjolfsson, E. M., Vestergaard, H. T., Hansen, S. L., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., 2010, In: Journal of Neurochemistry. 115, 6, p. 1398–1408

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glial cell biology: neuronal-glial interaction in nutrition and amino-acid-mediated neurotransmission

    Schousboe, Arne & Waagepetersen, Helle S., 2010, The newborn brain: Neuroscience and clinical applications. Lagercrantz, H., Hanson, M. A., Ment, L. R. & Peebles, D. M. (eds.). 2 ed. Cambridge: Cambridge University Press, p. 121-128

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  9. Published

    Hjernens forsvarsmur kortlagt og kopieret

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010, In: Lægemiddelforskning. 2010, p. 22-24

    Research output: Contribution to journalJournal articleCommunication

  10. Published

    Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis

    Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2010, In: Journal of Cerebral Blood Flow and Metabolism. 30, 8, p. 1527-37 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  12. Published

    A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures

    Suñol, C., Babot, Z., Cristòfol, R., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, Sep 2010, In: Neurochemical Research. 35, 9, p. 1384-1390 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2011
  15. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2011, Functional molecular imaging in hepatology. Bussum, The Netherlands: Bentham Science Publishers, p. 129-144

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  16. Published

    Glutamate and glutamine in brain disorders

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2011, Neurochemical mechanisms in diseases. Blass, J. P. (ed.). New York: Springer Publishing Company, Vol. 1. p. 195-212 (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  17. Published

    Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

    Walls, Anne Byriel, Eyjolfsson, E. M., Smeland, O. B., Nilsen, L. H., Schousboe, I., Schousboe, Arne, Sonnewald, U. & Waagepetersen, Helle S., 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 494-503 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    13C NMR spectroscopy and mass spectrometry analysis of intermediary metabolism in cultured neural cells

    Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 18 Mar 2011, Cell Culture Techniques. Aschner, M., Sunol, C. & Bal-Price, A. (eds.). p. 403-415 13 p. (Neuromethods, Vol. 56).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  19. Published

    Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

    Leke, R., Bak, Lasse Kristoffer, Anker, M., Melø, T. M., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Sonnewald, U., Schousboe, Arne & Waagepetersen, Helle S., 1 Apr 2011, In: Neurotoxicity Research. 19, 3, p. 496-510 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy

    Leke, R., Bak, Lasse Kristoffer, Iversen, P., Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Portela, L. V., Schousboe, Arne & Waagepetersen, Helle S., 1 Jun 2011, In: Journal of Neurochemistry. 117, 5, p. 824-32 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Buhl, M., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne, Møller, N. & Sørensen, M., 1 Aug 2011, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 301, 2, p. G269-77

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

    Dadsetan, S., Bak, Lasse Kristoffer, Sørensen, M., Keiding, S., Vilstrup, H., Ott, P., Leke, R., Schousboe, Arne & Waagepetersen, Helle S., 1 Sep 2011, In: Neurochemistry International. 59, 4, p. 482-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source

    Schousboe, Arne, Sickmann, H. M., Bak, Lasse Kristoffer, Schousboe, I., Jajo, F. S., Faek, S. A. A. & Waagepetersen, Helle S., 1 Dec 2011, In: Journal of Neuroscience Research. 89, 12, p. 1926-34 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2012
  25. Published

    Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

    Kreft, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2012, In: A S N Neuro. 4, 3, p. 187 199 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    Brain energy and ammonia metabolism

    Bak, Lasse Kristoffer, Schousboe, Arne & Waagepetersen, Helle S., 2012, Functional molecular imaging in hepatology. Bentham Science Publishers, Vol. 1. p. 129-144 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  27. Published

    Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model

    Sickmann, H. M., Waagepetersen, Helle S., Schousboe, Arne, Benie, A. J. & Bouman, S. D., 2012, In: Neurochemistry International. 60, 3, p. 267-75 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

    Frigerio, F., Karaca, M., De Roo, M., Mlynarik, V., Jensen, Dorte Skytt, Carobbio, S., Pajecka, K., Waagepetersen, Helle S., Gruetter, R., Muller, D. & Maechler, P., 2012, In: Journal of Neurochemistry. 123, 3, p. 342-348

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Delineation of glutamate pathways and secretory responses in pancreatic islets with ß-cell-specific abrogation of the glutamate dehydrogenase.

    Vetterli, L., Carobbio, S., Pournourmohammadi, S., Martin-del-Rio, R., Jensen, Dorte Skytt, Waagepetersen, Helle S., Tamarit-Rodriguez, J. & Maechler, P., 2012, In: Molecular Biology of the Cell. 23, 19, p. 3851-62

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation

    Brekke, E., Walls, Anne Byriel, Nørfeldt, L., Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Glia. 60, 1, p. 147-58 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  33. Published

    Impairment of the organization of locomotor and exploratory behaviors in bile duct-ligated rats

    Leke, R., de Oliveira, D. L., Mussulini, B. H. M., Pereira, M. S., Kazlauckas, V., Mazzini, G., Hartmann, C. R., Silveira, T. R., Simonsen, M., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Keiding, S., Schousboe, Arne & Portela, L. V., 2012, In: P L o S One. 7, 5, p. e36322

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    In-vitro models of the blood brain barrier

    Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  36. Published

    Novel model of neuronal bioenergetics: postsynaptic utilization of glucose but not lactate correlates positively with Ca2+ signalling in cultured mouse glutamatergic neurons

    Bak, Lasse Kristoffer, Obel, L. L. F., Walls, Anne Byriel, Schousboe, Arne, Faek, S. A. A., Jajo, F. S. & Waagepetersen, Helle S., 2012, In: A S N Neuro. 4, 3, p. 151-160

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Quantitative importance of the pentose phosphate pathway determined by incorporation of 13C from [2-13C]- and [3-13C]glucose into TCA cycle intermediates and neurotransmitter amino acids in functionally intact neurons

    Brekke, E. M., Walls, Anne Byriel, Schousboe, Arne, Waagepetersen, Helle S. & Sonnewald, U., 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1788-1799 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons

    Bak, Lasse Kristoffer, Johansen, M. L., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Journal of Neuroscience Research. 90, 9, p. 1768-75 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

    Jensen, Dorte Skytt, Klawonn, A. M., Strid, M. H., Pajecka, K., Patruss, Y., Quintana-Cabrera, R., Bolanos, J. P., Schousboe, Arne & Waagepetersen, Helle S., 2012, In: Neurochemistry International. 61, 4, p. 490-497

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Brain glycogen: new perspectives on its metabolic function and regulation at the subcellular level

    Obel, L. L. F., Müller, M. S., Walls, Anne Byriel, Sickmann, H. M., Bak, Lasse Kristoffer, Waagepetersen, Helle S. & Schousboe, Arne, 2 Mar 2012, In: Frontiers in Neuroenergetics. 4, 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published
  42. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  43. Published

    Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase

    Vetterli, L., Carobbio, S., Pournourmohammadi, S., Martin-Del-Rio, R., Jensen, Dorte Skytt, Waagepetersen, Helle S., Tamarit-Rodriguez, J. & Maechler, P., Oct 2012, In: Molecular Biology of the Cell. 23, 19, p. 3851-62 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

    Frigerio, F., Karaca, M., De Roo, M., Mlynárik, V., Jensen, Dorte Skytt, Carobbio, S., Pajęcka, K., Waagepetersen, Helle S., Gruetter, R., Muller, D. & Maechler, P., Nov 2012, In: Journal of Neurochemistry. 123, 3, p. 342-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Primary cultures of astrocytes: their value in understanding astrocytes in health and disease

    Lange, S. C., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Norenberg, M. D., Nov 2012, In: Neurochemical Research. 37, 11, p. 2569-88 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Energy Metabolism of the Brain

    McKenna, M. C., Dienel, G. A., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 1 Dec 2012, Basic Neurochemistry. Elsevier, p. 200-231 32 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  47. 2013
  48. Published

    Amino acid neurotransmitter synthesis and removal

    Schousboe, Arne, Bak, Lasse Kristoffer, Madsen, K. K. & Waagepetersen, Helle S., 2013, Neuroglia. Kettenman, H. & Ransom, B. R. (eds.). 3. ed. Oxford: Oxford University Press, p. 443-456 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

    Larsen, Birger Brodin, Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, Helle S., 2013, In: Lægemiddelforskning. 2013, p. 47-49 3 p.

    Research output: Contribution to journalJournal articleCommunication

  50. Published

    Interorgan metabolism of ornithine phenylacetate (OP)-A novel strategy for treatment of hyperammonemia

    Dadsetan, S., Sørensen, M., Bak, Lasse Kristoffer, Vilstrup, H., Ott, P., Schousboe, Arne, Jalan, R., Keiding, S. & Waagepetersen, Helle S., 2013, In: Biochemical Pharmacology. 85, 1, p. 115-23 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Reply to letter to the editor by Zheng G et al. Venous blood ammonia can be associated with cerebral blood flow in hepatic encephalopathy

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., 2013, In: Hepatology. 58, 2, p. 833-834

    Research output: Contribution to journalComment/debateResearchpeer-review

  52. Published

    Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

    Dam, G., Keiding, S., Munk, O. L., Ott, P., Vilstrup, H., Bak, Lasse Kristoffer, Waagepetersen, Helle S., Schousboe, Arne & Sørensen, M., Jan 2013, In: Hepatology. 57, 1, p. 258-65 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Glutamate dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization

    Pajecka, K., Nielsen, C. W., Hauge, A., Zaganas, I., Bak, Lasse Kristoffer, Schousboe, Arne, Plaitakis, A. & Waagepetersen, Helle S., 26 Apr 2013, In: Neurochemical Research. 39, 3, p. 487-499

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

    Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

ID: 983216