Helena Dominguez

Helena Dominguez

Associate Professor


  1. Published

    Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

    Andersson, C., Krogager, M. L., Skals, R. K., Appel, E. V. R., Have, C. T., Grarup, N., Pedersen, O., Jeppesen, J. L., Pedersen, O. D., Dominguez, H., Dixen, U., Engstrøm, T., Tønder, N., Roden, D. M., Stender, S., Gislason, G. H., Enghusen-Poulsen, H., Hansen, T., Køber, L., Torp-Pedersen, C. & 1 others, Weeke, P. E., 2019, In: P L o S One. 14, 2, 12 p., e0211690.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Assessment of patients with a suspected cardioembolic ischemic stroke. A national consensus statement

    Aplin, M., Andersen, A., Brandes, A., Dominguez, Helena, Dahl, J. S., Damgaard, D., Iversen, Helle Klingenberg, Iversen, Kasper, Nielsen, E., Risum, N., Schmidt, Michael Rahbek & Andersen, N. H., 2021, In: Scandinavian Cardiovascular Journal. 55, 5, p. 315-325 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Reaching the Frail Elderly for the Diagnosis and Management of Atrial Fibrillation—REAFEL

    Bamberg, C., Ladegaard, C. T., Aalling, M., Jensen, D. M., Madsen, C. L., Kamil, S., Gudbergsen, Henrik Rindel, Saxild, T., Schiøtz, M. L., Grew, J., Castillo, L. S., Tousgaard, I., Johansen, R. L. R., Bardram, J. E., Frølich, Anne & Dominguez, Helena, 2023, In: International Journal of Environmental Research and Public Health. 20, 18, 14 p., 6783.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension

    Christiansen, B., Bellostas Muguerza, N., Petersen, A. M., Kveiborg, B., Madsen, C. R., Thomas, H., Ihlemann, N., Sørensen, J. C., Køber, Lars Valeur, Sørensen, H., Torp-Pedersen, C. & Dominguez, Helena, 2010, In: PLOS ONE. 5, 8, 8 p., e12461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications 1997- 2006

    Dominguez, Helena, Schramm, T. K., Norgaard, M. L., Abildstrøm, S. Z., Køber, Lars Valeur, Jørgensen, C., Guterbaum, T. J., Poulsen, H. E., Torp-Pedersen, Christian, Gislason, Gunnar Hilmar, Dominguez, H., Schramm, T. K., Norgaard, M. L., Abildstrøm, S. Z., Kober, L., Jørgensen, C., Guterbaum, T. J., Poulsen, H. E., Torp-Pedersen, Christian & Gislason, Gunnar Hilmar, 2009, In: Open Cardiovascular Medicine Journal. 3, p. 152-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes.

    Dominguez, Helena, Storgaard, H., Rask-Madsen, C., Steffen, H. T., Ihlemann, N., Baunbjerg, N. D., Spohr, C., Køber, Lars Valeur, Vaag, Allan & Torp-Pedersen, Christian, 2005, In: Journal of Vascular Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Insulin resistance and postprandial endothelial dysfunction: Does attenuation of postprandial hyperglycaemia make a difference?

    Dominguez, Helena, 2006, DIABETOLOGIA.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsCommunication

  8. Published

    Statin treatment still insufficient in patients receiving glucose-lowering medications in Denmark

    Dominguez, Helena, 2009, CARDIOLOGY.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsCommunication

  9. Published

    Insulin resistance: The cardiovascular aspect

    Dominguez, Helena, 2008, In: Hormone and Metabolic Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published
  11. Published

    T01-P-016 The insulin resistance syndrome and endothelial dysfunction—Does nateglinide make a difference?

    Dominguez, Helena, 2005, In: Atherosclerosis Supplements.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Reduced complement-component sC5b-9 in plasma predicts severe cardiac dysfunction after acute myocardial infarction treated with primary percutaneous coronary intervention

    Dominguez, Helena, 2008, EUROPEAN HEART JOURNAL.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsCommunication

  13. Published

    Effects of acute and chronic attenuation of postprandial hyperglycemia on postglucose-load endothelial function in insulin resistant individuals: is stimulation of first phase insulin secretion beneficial for the endothelial function?

    Dominguez, Helena, 2008, In: Hormone and metabolic research= Hormon-und Stoffwechselforschung= Hormones et metabolisme.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    National Background is Associated with Disparities in Initiation and Persistence to Statin Treatment in Subjects with Diabetes in Denmark

    Dominguez, Helena, Schramm, T. K., Gislason, Gunnar Hilmar, Norgaard, M. L., Raunsø, J., Abildstrøm, S. Z., Køber, Lars Valeur, Poulsen, Henrik Enghusen & Torp-Pedersen, Christian, 2010, In: Frontiers in Pharmacology. 1, p. 142

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Postprandial endothelial dysfunction, hyperglycaemia and hyperinsulinaemia in insulin resistance: is there a link?

    Dominguez, Helena, 2007, DIABETOLOGIA.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  16. Published

    Phosphorylative regulation of eNOS on thr495 and ser1177 during high glucose concentrations in HUVECs

    Dominguez, Helena, 2007, In: International Journal of Cardiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes

    Dominguez, Helena, Storgaard, H., Rask-Madsen, C., Steffen Hermann, T., Ihlemann, N., Baunbjerg Nielsen, D., Spohr, C., Køber, Lars Valeur, Vaag, Allan & Torp-Pedersen, Christian, 2005, In: Journal of Vascular Research. 42, 6, p. 517-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    In long-term hyperglycaemia, oxidative stress rather than hyperglycaemia per se impairs endothelial function

    Dominguez, Helena, 2007, HYPERTENSION.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  19. Published

    The Role of Glycated Proteins on Cardiovascular Diabetic Complications: New Findings

    Dominguez, Helena & Sánchez-Ferrer, C. F., 17 Oct 2017, In: Journal of the American College of Cardiology. 70, 16, p. 2020-2021 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  20. Published

    Does Left Atrial Appendage Amputation During Routine Cardiac Surgery Reduce Future Atrial Fibrillation and Stroke?

    Dominguez, Helena, Madsen, C. V., Westh, O. N. H., Pallesen, P. A., Carrranza, C. L., Irmukhamedov, A. & Park-Hansen, J., Jan 2018, In: Current Cardiology Reports. 20, 10, 6 p., 99.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Common source of miscalculation and misclassification of P-wave negativity and P-wave terminal force in lead V1

    Fabricius-Bjerre, A., Kumarathurai, P., Larsen, B. S., Dominguez, Helena, Kanters, Jørgen K. & Sajadieh, Ahmad, 2019, In: Journal of Electrocardiology. 53, p. 85-88

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure--a randomized study

    Falskov, B., Hermann, T. S., Raunsø, J., Christiansen, B., Rask-Madsen, C., Major-Pedersen, A., Køber, Lars Valeur, Torp-Pedersen, Christian & Dominguez, Helena, 2011, In: Cardiovascular Diabetology. 10, p. 91

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive

    Falskov, B., Hermann, T. S., Rask-Madsen, C., Major-Pedersen, A., Christiansen, B., Raunsø, J., Køber, Lars Valeur, Torp-Pedersen, Christian & Dominguez, Helena, 2011, In: Vascular Health and Risk Management (Online). 7, p. 771-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Telemedicine Support for Primary Care Providers versus Usual Care in Patients with Heart Failure: Protocol of a Pragmatic Cluster Randomised Trial within the Brazilian Heart Insufficiency with Telemedicine (BRAHIT) Study

    Graever, L., Issa, A. F. C., Fonseca, V. B. P. D., Melo, M. M., Silva, G. P. D. C. D., Nóbrega, I. C. P. D., Savassi, L. C. M., Dias, M. B., Gomes, M. K., Lapa e Silva, J. R., Guimarães, R. M., Seródio, R. C., Frølich, Anne, Gudbergsen, Henrik Rindel, Jakobsen, J. C. & Dominguez, Helena, 2023, In: International Journal of Environmental Research and Public Health. 20, 11, 5933.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    H2O2 Treatment of HUVECs Facilitates PKC Mediated Thr495 Phosphorylation on eNOS when Pre-treated with High Glucose Levels

    Guterbaum, T. J., Braunstein, T. H., Fossum, A., von Holstein-Rathlou, Niels-Henrik, Torp-Pedersen, Christian & Dominguez, Helena, 17 Nov 2015, In: Journal of Metabolic Syndrome. 04, p. 1-9 9 p., 1000189.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Initiation and persistence with warfarin therapy in atrial fibrillation according to ethnicity

    Hansen, C. M., Olesen, J. B., Hansen, M. L., Azimi, A., Torp-Pedersen, Christian & Dominguez, Helena, 2012, In: Frontiers in Pharmacology. 3, p. 123

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes.

    Hermann, T., Li, W., Dominguez, Helena, Ihlemann, N., Rask-Madsen, C., Major-Pedersen, A., Nielsen, D., Hansen, K., Hawkins, M., Køber, Lars Valeur & Torp-Pedersen, Christian, Mar 2006, In: Journal of Clinical Endocrinology and Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

    Hermann, T. S., Li, W., Dominguez, Helena, Ihlemann, N., Rask-Madsen, C., Major-Pedersen, A., Nielsen, D. B., Winther, Kaj, Hawkins, M., Kober, L. & Torp-Pedersen, Christian, 2005, In: Journal of Clinical Endocrinology and Metabolism. 91, 3, p. 1001-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Prolonged local forearm hyperinsulinemia induces sustained enhancement of nitric oxide-dependent vasodilation in healthy subjects

    Hermann, T. S., Ihlemann, N., Dominguez, Helena, Rask-Madsen, C., Køber, Lars Valeur & Torp-Pedersen, Christian, 2005, In: Endothelium. 11, 5-6, p. 231-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects

    Ihlemann, N., Rask-Madsen, C., Perner, Anders, Dominguez, Helena, Hermann, T., Køber, Lars Valeur & Torp-Pedersen, Christian, 2003, In: American Journal of Physiology: Heart and Circulatory Physiology. 285, 2, p. H875-82

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Frequency of electrocardiographic alterations and pericardial effusion in patients with uncomplicated malaria

    Kaagaard, M. D., Matos, L. O., Holm, A. E., Gomes, L. C., Wegener, A., Lima, K. O., Vieira, I. V. M., de Souza, R. M., Marinho, C. R. F., Hviid, Lars, Vestergaard, L. S., Dominguez, Helena, Biering-Sørensen, Tor, Silvestre, O. M. & Brainin, P., 2022, In: American Journal of Cardiology. 165, p. 116-123

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Incidence of myocardial infarction, heart failure, and cardiovascular mortality in patients with peripheral artery disease: trends between 1997 and 2016

    Kamil, S., Sehested, T. S. G., Houlind, K., Lassen, J. F., Gislason, Gunnar Hilmar & Dominguez, Helena, 2023, In: European Heart Journal - Quality of Care and Clinical Outcomes. 9, 2, p. 142–149 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Time trends in the risk of atrial fibrillation and ischaemic stroke in patients with peripheral artery disease between 1997 and 2015

    Kamil, S., Sehested, T., Houlind, K., Lassen, J., Gislason, Gunnar Hilmar & Dominguez, Helena, 2020, In: Open Heart. 7, 1, e001185.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Trends in use of cardioprotective medication in peripheral artery disease: A nationwide study

    Kamil, S., Sehested, T. S. G., Houlind, K., Lassen, J. F., Gislason, Gunnar Hilmar & Dominguez, Helena, 2021, In: Journal of the American Heart Association. 10, 15, e020333.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Diabetes and risk of peripheral artery disease in patients undergoing first-time coronary angiography between 2000 and 2012: a nationwide study

    Kamil, S., Sehested, T. S. G., Carlson, N., Houlind, K., Lassen, J. F., Bang, C. N., Dominguez, Helena, Pedersen, C. T. & Gislason, Gunnar Hilmar, 2019, In: BMC Cardiovascular Disorders. 19, 1, 9 p., 234.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome: VERDICT Randomized Controlled Trial

    Kofoed, K. F., Kelbæk, H., Hansen, P. R., Torp-Pedersen, C., Høfsten, D., Kløvgaard, L., Holmvang, L., Helqvist, S., Jørgensen, E., Galatius, S., Pedersen, F., Bang, L., Saunamaki, K., Clemmensen, P., Linde, J. J., Heitmann, M., Wendelboe Nielsen, O., Raymond, I. E., Kristiansen, O. P., Svendsen, I. H. & 18 others, Bech, J., Dominguez, Helena, Kragelund, C., Hansen, T. F., Hove, Jens Dahlgaard, Jørgensen, T., Fornitz, Gitte Gleerup, Steffensen, R., Jurlander, B., Abdulla, J., Lyngbæk, S., Elming, H., Therkelsen, S. K., Abildgaard, U., Jensen, J. S., Gislason, Gunnar Hilmar, Køber, Lars Valeur & Engstrøm, Thomas, 11 Dec 2018, In: Circulation. 138, 24, p. 2741-2750 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Deepaware: A hybrid deep learning and context-aware heuristics-based model for atrial fibrillation detection

    Kumar, D., Peimankar, A., Sharma, K., Dominguez, Helena, Puthusserypady, S. & Bardram, J. E., 2022, In: Computer Methods and Programs in Biomedicine. 221, 11 p., 106899.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    mCardia: A Context-Aware ECG Collection System for Ambulatory Arrhythmia Screening

    Kumar, D., Maharjan, R., Maxhuni, A., Dominguez, Helena, Frølich, Anne & Bardram, J. E., 2022, In: ACM Transactions on Computing for Healthcare. 3, 2, 28 p., 20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study

    Kveiborg, B., Hermann, T. S., Major-Pedersen, A., Christiansen, B., Rask-Madsen, C., Raunsø, J., Køber, Lars Valeur, Torp-Pedersen, Christian & Dominguez, Helena, 2010, In: Cardiovascular Diabetology. 9, p. 21

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Reaching Frail Elderly Patients to Optimize Diagnosis and Management of Atrial Fibrillation (REAFEL): A Feasibility Study of a Cross-Sectoral Shared-Care Model

    Ladegaard, C. T., Bamberg, C., Aalling, M., Jensen, D. M., Kamstrup-Larsen, Nina Katrine, Madsen, C. V., Kamil, S., Gudbergsen, Henrik Rindel, Saxild, T., Schiotz, M. L., Grew, J., Castillo, L. S., Frolich, A. & Dominguez, Helena, 2022, In: International Journal of Environmental Research and Public Health. 19, 12, 10 p., 7383.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Atrial cardiomyopathy in patients with ischaemic stroke: a cross-sectional and prospective cohort study-the COAST study

    Larsen, B. S., Aplin, M., Høst, N., Dominguez, Helena, Christensen, Hanne Krarup, Christensen, Louisa Marguerite, Havsteen, I., Prescott, Eva, Jensen, G. B., Vejlstrup, N., Bertelsen, L. & Sajadieh, Ahmad, 2022, In: BMJ Open. 12, 5, e061018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Left atrial late gadolinium enhancement in patients with ischaemic stroke

    Larsen, B. S., Bertelsen, L., Christensen, H., Hadad, R., Aplin, M., Høst, N., Christensen, Louisa Marguerite, Havsteen, I., Prescott, Eva, Dominguez, Helena, Jensen, G. B., Vejlstrup, N. & Sajadieh, Ahmad, 2023, In: European Heart Journal Cardiovascular Imaging. 24, 5, p. 625-634 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Frequency and risk factors of atrial fibrillation after acute abdominal surgery: A prospective cohort study

    Madsen, C. L., Leerhøy, B., Jørgensen, Lars Nannestad, Meyhoff, Christian Sylvest, Sajadieh, Ahmad & Dominguez, Helena, 2024, In: Acta Anaesthesiologica Scandinavica. 68, 3, p. 345-353 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The left atrial appendage closure by surgery-2 (LAACS-2) trial protocol rationale and design of a randomized multicenter trial investigating if left atrial appendage closure prevents stroke in patients undergoing open-heart surgery irrespective of preoperative atrial fibrillation status and stroke risk

    Madsen, C. L., Park-Hansen, J., Irmukhamedov, A., Carranza, C. L., Rafiq, S., Rodriguez-Lecoq, R., Palmer-Camino, N., Modrau, I. S., Hansson, E. C., Jeppsson, A., Hadad, R., Moya-Mitjans, A., Greve, A. M., Christensen, R., Carstensen, H. G., Høst, N. B., Dixen, U., Torp-Pedersen, C., Køber, L., Gögenur, I. & 5 others, Truelsen, Thomas Clement, Kruuse, Christina Rostrup, Sajadieh, Ahmad, Dominguez, Helena & LAACS-2 trial Investigators, L. T. I., 2023, In: American Heart Journal. 264, p. 133-142

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Randomized Trial of Surgical Left Atrial Appendage Closure: Protection Against Cerebrovascular Events

    Madsen, C. V., Park-Hansen, J., Holme, S. J. V., Irmukhamedov, A., Carranza, C. L., Greve, A. M., Al-Farra, G., Riis, R. G. C., Nilsson, B., Clausen, J. S. R., Nørskov, A. S., Kruuse, Christina Rostrup, Truelsen, Thomas Clement & Dominguez, Helena, 2023, In: Seminars in Thoracic and Cardiovascular Surgery. 35, 4, p. 664-672 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Predictors of Postoperative Atrial Fibrillation After Abdominal Surgery and Insights from Other Surgery Types

    Madsen, C. V., Jørgensen, Lars Nannestad, Leerhoy, B., Gögenur, Ismail, Ekeloef, S., Sajadieh, Ahmad & Dominguez, Helena, 2020, In: Research Reports in Clinical Cardiology. 2020, 11, p. 31-38

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Effects of oral glucose load on endothelial function and on insulin and glucose fluctuations in healthy individuals

    Major-Pedersen, A., Ihlemann, N., Hermann, T. S., Christiansen, B., Dominguez, Helena, Kveiborg, B., Nielsen, D. B., Svendsen, O. L., Køber, Lars Valeur & Torp-Pedersen, Christian, 2008, In: Experimental Diabetes Research. 2008, p. 672021

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF Registry

    GARFIELD‐AF, G., 2019, In: Journal of the American Heart Association. 8, 3, 25 p., 010510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways

    Palsgaard, J., Brøns, C., Friedrichsen, M., Dominguez, Helena, Jensen, M., Storgaard, H., Spohr, C., Torp-Pedersen, Christian, Borup, R., De Meyts, P. & Vaag, Allan, 2009, In: PLoS ONE. 4, 8, e6575.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Adding left atrial appendage closure to open heart surgery provides protection from ischemic brain injury six years after surgery independently of atrial fibrillation history: the LAACS randomized study

    Park-Hansen, J., Holme, S. J. V., Irmukhamedov, A., Carranza, C. L., Greve, A. M., Al-Farra, G., Riis, R. G. C., Nilsson, B., Clausen, J. S. R., Nørskov, A. S., Kruuse, Christina Rostrup, Rostrup, E. & Dominguez, Helena, 2018, In: Journal of Cardiothoracic Surgery. 13, 1, 8 p., 53.

    Research output: Contribution to journalJournal articleResearchpeer-review

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