Hans K Hasselbalch
Clinical Professor
Department of Clinical Medicine
Køgevej 7 - 13, 4000 Roskilde
Member of:
Internal Medicine: Haematology
- 1996
- Published
Sonographic measurement of the thymus in infants
Hasselbalch, Hans Carl, Nielsen, Michael Bachmann, Jeppesen, Dorthe Lisbeth, Pedersen, J. F. & Karkov, J., 1996, In: European Radiology. 6, 5, p. 700-703 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence
Lataillade, J. J., Pierre-Louis, O., Uzan, G., Jasmin, C., Martyre, M. C., Bousse-Kerdiles, M. C. L. & Hasselbalch, Hans Carl, 2008, In: Blood. 112, 8, p. 3026-3035 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis
Hasselbalch, Hans Carl, Skov, V., Larsen, T. S., Thomassen, M., Riley, C. H., Jensen, M. K., Bjerrum, O. W. & Kruse, T. A., 2011, In: Leukemia Research. 35, 10, p. 1330-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon alpha2 in the treatment of hematological malignancies. status and perspectives
Hasselbalch, Hans Carl, 1 Jan 2011, In: Current Drug Targets. 12, 3, p. 387-391 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon-alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Status and perspectives
Hasselbalch, Hans Carl, Larsen, T. S., Riley, C. H., Jensen, M. K. & Kiladjian, J., 1 Jan 2011, In: Current Drug Targets. 12, 3, p. 392-419 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European leukemiaNet
Barbui, T., Barosi, G., Birgegard, G., Cervantes, F., Finazzi, G., Griesshammer, M., Harrison, C., Hasselbalch, H. C., Hehlmann, R., Hoffman, R., Kiladjian, J-J., Kröger, N., Mesa, R., McMullin, M. F., Pardanani, A., Passamonti, F., Vannucchi, A. M., Reiter, A., Silver, R. T., Verstovsek, S. & 1 others, , 20 Feb 2011, In: Journal of Clinical Oncology. 29, 6, p. 761-770 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon alfa in the treatment of philadelphia-negative chronic myeloproliferative neoplasms
Hasselbalch, Hans Carl, Kiladjian, J. & Silver, R. T., 20 Jun 2011, In: Journal of Clinical Oncology. 29, 18Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increase in circulating CD4CD25Foxp3 T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α
Riley, C. H., Morten Krogh, J., Brimnes, M. K., Straten, P. T., Svane, Inge Marie, Hasselbalch, Hans Carl & Bjerrum, O. W., 25 Aug 2011, In: Blood. 118, 8, p. 2170-2173 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents
Ghanima, W., Bussel, J. B., Junker, P., Hasselbalch, Hans Carl, Gudbrandsdottir, S., Boiocchi, L., Geyer, J. T., Orazi, A. & Feng, X., 1 Oct 2011, In: British Journal of Haematology. 155, 2, p. 248-255 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms
Hasselbalch, Hans Carl, 1 Dec 2011, In: Expert Review of Hematology. 4, 6, p. 637-655 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic myeloproliferative neoplasms and subsequent cancer risk: A Danish population-based cohort study
Frederiksen, H., Farkas, D. K., Christiansen, C. F., Sørensen, H. T. & Hasselbalch, Hans Carl, 15 Dec 2011, In: Blood. 118, 25, p. 6515-6520 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
A novel immunohistochemical sequential multi-labelling and erasing technique enables epitope characterization of bone marrow pericytes in primary myelofibrosis
Madelung, A., Bzorek, M., Bondo, H., Zetterberg, E., Bjerrum, O. W., Hasselbalch, Hans Carl, Scheding, S. & Ralfkiaer, E., 2012, In: Histopathology. 60: 554 – 660.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones
Andersen, Christen Bertel L, Asmar, F., Klausen, T., Hasselbalch, Hans Carl & Grønbæk, K., 2012, In: Leukemia Research Reports. 2, 1, p. 1-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A highly sensitive quantitative real-time pcr assay for determination of mutant jak2 exon 12 allele burden
Kjær, L., Riley, C. H., Westman, M., Høgdall, Estrid Vilma Solyom, Bjerrum, O. W. & Hasselbalch, Hans Carl, 5 Mar 2012, In: PLOS ONE. 7, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms
Andersen, Christen Bertel L, Grønbæk, Kirsten & Hasselbalch, Hans Carl, 1 Apr 2012, In: Leukemia Research. 36, 4, p. 485-487 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?
Hasselbalch, Hans Carl, 5 Apr 2012, In: Blood. 119, 14, p. 3219-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis
Skov, V., Thomassen, M., Kruse, T. A., Riley, C. H., Jensen, M. K., Bjerrum, O. W., Hasselbalch, Hans Carl & Larsen, T. S., 1 Sep 2012, In: Experimental Hematology. 40, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thrombopoietin-receptor agonists in haematological disorders: The Danish experience
Gudbrandsdottir, S., Hasselbalch, Hans Carl & Frederiksen, H., 1 Sep 2012, In: Platelets. 23, 6, p. 423-429 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance
Skov, V., Thomassen, M., Kruse, T. A., Larsen, T. S., Riley, C. H., Jensen, M. S. K., Bjerrum, O. W. & Hasselbalch, Hans Carl, 1 Nov 2012, In: Leukemia Research. 36, 11, p. 1387-1392 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Hasselbalch, Hans Carl, Feb 2013, In: Leukemia Research. 37, 2, p. 214-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis
Silver, R. T., Kiladjian, J. & Hasselbalch, Hans Carl, Feb 2013, In: Expert Review of Hematology. 6, 1, p. 49-58 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of cytokines in the initiation and progression of myelofibrosis
Hasselbalch, Hans Carl, Apr 2013, In: Cytokine & Growth Factor Reviews. 24, 2, p. 133-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state
Bjørn, M. E., Andersen, Christen Bertel L, Jensen, M. K. & Hasselbalch, Hans Carl, 2014, In: European Journal of Haematology. 93, 3, p. 224-228 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome
Andersen, Christen Bertel L, Nielsen, H. M., Sommer Kristensen, L., Helbo, A. S., Vikeså, J., Jønson, L., Nielsen, Finn Cilius, Hasselbalch, Hans Carl, Bjerrum, O. W., Punj, V. & Grønbæk, Kirsten, 2015, In: OncoTarget. 6, 38, p. 40588-97 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of the blood eosinophil count with hematological malignancies and mortality
Andersen, Christen Bertel L, Siersma, Volkert Dirk, Hasselbalch, Hans Carl, Vestergaard, H., Mesa, R., Felding, P., Olivarius, Niels de Fine & Bjerrum, O. W., Mar 2015, In: American Journal of Hematology. 90, 3, p. 225-229 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience
Madelung, A. B., Bondo, H., Stamp, I., Løvgreen, P., Nielsen, S. L., Falensteen, A., Knudsen, H., Svendsen, K. D., Lange, Theis, Ralfkiaer, E., Nielsen, K., Hasselbalch, Hans Carl & Thiele, J., Sep 2015, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 123, 9, p. 787-92 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A new internet-based tool for reporting and analysing patient-reported outcomes and the feasibility of repeated data collection from patients with myeloproliferative neoplasms
Brochmann, N., Zwisler, A., Kjerholt, M., Flachs, E. M., Hasselbalch, Hans Carl & Andersen, Christen Bertel L, 2016, In: Quality of Life Research. 25, 4, p. 835-846 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera
Riley, C. H., Brimnes, M. K., Hansen, M., Jensen, M. K., Hasselbalch, Hans Carl, Kjaer, L., Straten, P. T. & Svane, Inge Marie, 2016, In: European Journal of Haematology. 97, 1, p. 83-92 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimal therapy for polycythemia vera and essential thrombocythemia: Preferred use of interferon therapy based on phase 2 trials
Silver, R. T. & Hasselbalch, Hans Carl, 2016, In: Hematology. 21, 7, p. 387-391 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antecedent cardiovascular disease and autoimmunity in Philadelphia-negative chronic myeloproliferative neoplasms
Sørensen, A. L. & Hasselbalch, Hans Carl, 1 Feb 2016, In: Leukemia Research. 41, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chronic inflammation and autoimmunity as risk factors for the development of chronic myelomonocytic leukemia?
Elbæk, M. V., Sørensen, A. L. & Hasselbalch, Hans Carl, 2 Aug 2016, In: Leukemia and Lymphoma. 57, 8, p. 1793-1799 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents
Brochmann, N., Flachs, E. M., Christensen, A. I., Andersen, Christen Bertel L, Juel, K., Hasselbalch, Hans Carl & Zwisler, A., 2017, In: Clinical Epidemiology. 9, p. 141-150Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A retrospective analysis of the impact of treatments and blood counts on survival and the risk of vascular events during the course of polycythaemia vera
Enblom-Larsson, A., Girodon, F., Bak, M., Hersby, D., Jooste, V., Hasselbalch, Hans Carl, Johansson, P. & Andreasson, B., 2017, In: British Journal of Haematology. 177, 5, p. 800-805Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age-Related Macular Degeneration in Patients With Chronic Myeloproliferative Neoplasms
Bak, M., Sørensen, Torben Lykke, Flachs, E. M., Zwisler, A., Juel, K., Frederiksen, H. & Hasselbalch, Hans Carl, 2017, In: JAMA Ophthalmology. 135, 8, p. 835-843Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations
Myrtue Nielsen, H., Andersen, Christen Bertel L, Westman, M., Sommer Kristensen, L., Asmar, F., Arvid Kruse, T., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Hasselbalch, Hans Carl, Punj, V. & Grønbæk, Kirsten, 2017, In: Scientific Reports. 7, 11 p., 6774.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, Hans Carl & Ottesen, J. T., 2017, In: PLOS ONE. 12, 8, 18 p., e0183620.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib
Bjørn, M. E. & Hasselbalch, Hans Carl, 2017, In: Expert Review of Hematology. 10, 5, p. 393-404Research output: Contribution to journal › Review › Research › peer-review
- Published
Molecular profiling as a novel tool to predict response to interferon-α2 in MPNs: The proof of concept in early myelofibrosis
Hasselbalch, Hans Carl, 2017, In: Cancer. 123, 14, p. 2600-2603Research output: Contribution to journal › Editorial › Research
- Published
Second malignancies in hydroxyurea and interferon-treated Philadelphia-negative myeloproliferative neoplasms
Hansen, I. O., Sørensen, A. L. & Hasselbalch, Hans Carl, 2017, In: European Journal of Haematology. 98, 1, p. 75-84Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy
Holmstrom, M. O., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: OncoImmunology. 6, 11, 3 p., e1358334.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
Holmström, M. O., Hjortso, M. D., Ahmad, S. M., Met, Özcan, Martinenaite, E., Riley, C., Straten, P., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: Leukemia. 31, p. 495-498Research output: Contribution to journal › Letter › Research › peer-review
- Published
Non-invasive imaging of retinal blood flow in myeloproliferative neoplasms
Willerslev, A., Hansen, M. M., Klefter, O. N., Bjerrum, O. W., Hasselbalch, Hans Carl, Clemmensen, S. N., Larsen, Michael & Munch, I. C., Mar 2017, In: Acta Ophthalmologica. 95, 2, p. 146–152Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre-diagnostic period
Hansen, Jakob Werner, Sandholdt, H., Siersma, Volkert Dirk, mxz703, mxz703, Holmberg, S., Bjerrum, O. W., Hasselbalch, Hans Carl, Olivarius, Niels de Fine, Grønbæk, Kirsten & Andersen, Christen Bertel L, Jul 2017, In: American Journal of Hematology. 92, 7, p. E130-E132 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- 2018
- Published
Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms
Tolstrup Larsen, R., Tang, L. H., Brochmann, N., Meulengracht Flachs, E., Illemann Christensen, A., Hasselbalch, Hans Carl & Zwisler, A., 2018, In: European Journal of Haematology. 100, 6, p. 550-559 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Classification and Personalized Prognosis in Myeloproliferative Neoplasms
Grinfeld, J., Nangalia, J., Baxter, E. J., Wedge, D. C., Angelopoulos, N., Cantrill, R., Godfrey, A. L., Papaemmanuil, E., Gundem, G., MacLean, C., Cook, J., O'Neil, L., O'Meara, S., Teague, J. W., Butler, A. P., Massie, C. E., Williams, N., Nice, F. L., Andersen, C. L., Hasselbalch, H. C. & 7 others, , 2018, In: The New England Journal of Medicine. 379, 15, p. 1416-1430Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinguishing myelofibrosis from polycythemia vera and essential thrombocythemia: The utility of enumerating circulating stem cells with aberrant hMICL expression by flow cytometry
Herborg, L. L., Nederby, L., Hasselbalch, Hans Carl, Aggerholm, A. & Roug, A. S., 2018, In: International Journal of Laboratory Hematology. 40, 3, p. 320-325Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of rituximab and dexamethasone on regulatory and proinflammatory B-cell subsets in patients with primary immune thrombocytopenia
Gudbrandsdottir, S., Brimnes, M., Køllgaard, T., Hasselbalch, Hans Carl & Nielsen, C. H., 2018, In: European Journal of Haematology. 100, 1, p. 45-52Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Myeloproliferative Neoplasms in Danish Twins
Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, Hans Carl & Christensen, K., 2018, In: Acta Haematologica. 139, 3, p. 195-198 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet
Barbui, T., Tefferi, A., Vannucchi, A. M., Passamonti, F., Silver, R. T., Hoffman, R., Verstovsek, S., Mesa, R., Kiladjian, J-J., Hehlmann, R., Reiter, A., Cervantes, F., Harrison, C., Mc Mullin, M. F., Hasselbalch, H. C., Koschmieder, S., Marchetti, M., Bacigalupo, A., Finazzi, G., Kroeger, N. & 3 others, , 2018, In: Leukemia. 32, 5, p. 1057-1069Research output: Contribution to journal › Review › Research › peer-review
- Published
Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study
Pedersen, K. M., Bak, M., Sørensen, A. L., Zwisler, A., Ellervik, Christina, Larsen, M. K., Hasselbalch, Hans Carl & Tolstrup, J. S., 2018, In: Cancer Medicine. 7, 11, p. 5796-5802 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 2849472
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A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
153
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Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
137
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Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
Research output: Contribution to journal › Journal article › Research › peer-review
Published