Frederik Diness

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Green Bioorganic Chemistry - Organic Chemistry, Biomolecules and Chemical Biology

 

My research group mainly works in the fields of (bio)-organic chemistry, green chemistry and chemical biology. The overall goals of the work are to developed new chemistry based tools for combating diseases and to make organic chemical production and products more environmental friendly.

The work involves a broad range of scientific disciplines including: Organic Chemistry, Protein Chemistry, Medicinal Chemistry, Green Chemistry, G Protein-Coupled Receptors, Cell Biology, Enzyme Inhibition, Neuroreceptors, Protein-Protein Interactions, Natural Product Chemistry, Solid-Phase Chemistry, Peptide Chemistry, Enantioselective Reactions, Nucleophilic Aromatic Substitution (SNAr), Multicomponent Reactions, Polymer Chemistry, Nanoparticles, Bioassay Development, Protein-Drug Conjugates and Biodegradation. 

In addition to aiming at developing directly applicable new technologies we have broad interests in understanding: 1) the mechanisms behind reactions of organic molecules, especially nucleophilic aromatic substitutions and reactions of amino acids, peptides and proteins; 2) how changes in the chemical structure of peptides affect their 3D-structures and physicochemical properties; 3) how molecules interacts and how this may affect living organisms.

If you have interests in our research you are welcome to come by my office or contact me by email or phone.  

Current research

Titles of some present project are given below.

Biodegradable plastic – Developing biodegradable plastic to replace PET bottles and Styrofoam cups.     

 

Protein-drug conjugation – New methods for efficient protein conjugation targeting novel anti-cancer agents.

  

Enzyme inhibition – New concepts for covalent inhibition of enzymes targeting virus infections and cancer.

 

Chemical modified bioactive peptides – Study peptides with regards to chemical modification, their 3D structure and activity towards the melanocortin and opioid receptors.

 

Nucleophilic aromatic substitution (SNAr) – Study the mechanisms of SNAr reactions using fluorobenzene derivatives in order to develop green and efficient methods for arylation of nucleophiles.