Erika Villanueva

Erika Villanueva

Postdoc

ORCID: 0000-0003-2270-3383

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  1. A fully humanized transgenic mouse model of Huntington disease

    Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, Niels Henning, Zhang, W., Villanueva, Erika Bianca, Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 18-34 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

    Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, Seth, P. P. & Hayden, M. R., 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT

    Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, Erika Bianca, Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., Sep 2018, p. A91-A91.

    Research output: Contribution to conference › Poster › Research

  4. An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

    Southwell, A. L., Smith-Dijak, A., Kay, C., Sepers, M., Villanueva, Erika Bianca, Parsons, M. P., Xie, Y., Anderson, L., Felczak, B., Waltl, S., Ko, S., Cheung, D., Dal Cengio, L., Slama, R., Petoukhov, E., Raymond, L. A. & Hayden, M. R., 1 Sep 2016, In: Human Molecular Genetics. 25, 17, p. 3654-3675 22 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

    Southwell, A. L., Franciosi, S., Villanueva, Erika Bianca, Xie, Y., Winter, L. A., Veeraraghavan, J., Jonason, A., Felczak, B., Zhang, W., Kovalik, V., Waltl, S., Hall, G., Pouladi, M. A., Smith, E. S., Bowers, W. J., Zauderer, M. & Hayden, M. R., Apr 2015, In: Neurobiology of Disease. 76, p. 46-56 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells

    Ionescu, V. A., Villanueva, Erika Bianca, Hashioka, S., Bahniwal, M. & Klegeris, A., 28 Feb 2011, In: Brain Research Bulletin. 84, 3, p. 244-51 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

    Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, Erika Bianca, Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 Jan 2018, In: Human Molecular Genetics. 27, 2, p. 239-253 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

    Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, Niels Henning, Parsons, M. P., Villanueva, Erika Bianca, Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

    Southwell, A. L., Skotte, Niels Henning, Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, Erika Bianca, Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

    Little, J. P., Simtchouk, S., Schindler, S. M., Villanueva, Erika Bianca, Gill, N. E., Walker, D. G., Wolthers, K. R. & Klegeris, A., May 2014, In: Molecular and Cellular Neuroscience. 60, p. 88-96 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies

    Bahniwal, M., Villanueva, Erika Bianca & Klegeris, A., Apr 2011, In: Journal of Neuroimmunology. 233, 1-2, p. 65-72 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice

    Villanueva, Erika Bianca, Tresse-Gommeaux, Emilie, Liu, Yawei, Duarte, J. N., Jimenez-Duran, G., Ejlerskov, P., Kretz, O., Loreth, D., Goldmann, T., Prinz, M. & Issazadeh-Navikas, Shohreh, 2021, In: Annals of Neurology. 90, 5, p. 789-807

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

    Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, Niels Henning, Doty, C. N., Vaid, K., Villanueva, Erika Bianca, Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., Nov 2013, In: Nucleic Acids Research. 41, 21, p. 9634-50 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells

    Villanueva, Erika Bianca, Little, J. P., Lambeau, G. & Klegeris, A., 2012, In: Molecular and Cellular Neuroscience.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Synthesis and biological evaluation of novel pyrazole compounds

    Youssef, A. M., Neeland, E. G., Villanueva, Erika Bianca, White, M. S., El-Ashmawy, I. M., Patrick, B., Klegeris, A. & Abd-El-Aziz, A. S., 1 Aug 2010, In: Bioorganic & Medicinal Chemistry. 18, 15, p. 5685-96 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

    Youssef, A. M., White, M. S., Villanueva, Erika Bianca, El-Ashmawy, I. M. & Klegeris, A., 1 Mar 2010, In: Bioorganic & Medicinal Chemistry. 18, 5, p. 2019-28 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease

    Villanueva, Erika Bianca, Little, J. P. & Klegeris, A., 30 Nov 2015, Recent Advances in Medicinal Chemistry. Atta-ur-Rahman, Choudhary, M. I. & Perry, G. (eds.). Bentham Science Publishers, p. 59-75

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  18. Published

    Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinsons Disease

    Little, J. P., Villanueva, Erika Bianca & Klegeris, A., 1 Jun 2011, In: Mini-Reviews in Medicinal Chemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease

    Little, J. P., Villanueva, Erika Bianca & Klegeris, A., Jun 2011, In: Mini reviews in medicinal chemistry. 11, 7, p. 582-90 9 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

    Southwell, A. L., Smith, S. E. P., Davis, T. R., Caron, N. S., Villanueva, Erika Bianca, Xie, Y., Collins, J. A., Ye, M. L., Sturrock, A., Leavitt, B. R., Schrum, A. G. & Hayden, M. R., 15 Jul 2015, In: Scientific Reports. 5, p. 12166

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 157553808