Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents
Research output: Contribution to journal › Journal article › Research › peer-review
Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.
Original language | English |
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Journal | Bioorganic & Medicinal Chemistry |
Volume | 18 |
Issue number | 5 |
Pages (from-to) | 2019-28 |
Number of pages | 10 |
ISSN | 0968-0896 |
DOIs | |
Publication status | Published - 1 Mar 2010 |
Externally published | Yes |
Bibliographical note
Copyright 2010 Elsevier Ltd. All rights reserved.
- Animals, Anti-Inflammatory Agents/chemical synthesis, Cell Line, Tumor, Cyclooxygenase 1/metabolism, Cyclooxygenase 2/metabolism, Edema/chemically induced, Granuloma/chemically induced, HL-60 Cells, Humans, Neuroprotective Agents/chemical synthesis, Rats, Thiazolidinediones/chemical synthesis
Research areas
ID: 236610080