Christoffer Clemmensen
Associate Professor
Clemmensen Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal
2200 København N.
- 2012
- Published
L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances
Clemmensen, Christoffer, Madsen, A. N., Smajilovic, S., Holst, Birgitte & Bräuner, Hans, 2012, In: Amino Acids. 43, 3, p. 1265-1275Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Enhanced voluntary wheel running in GPRC6A receptor knockout mice
Clemmensen, Christoffer, Pehmøller, C., Klein, A. B., Ratner, C., Wojtaszewski, Jørgen F P & Bräuner, Hans, 2013, In: Physiology & Behavior. 118, p. 144-151 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice
Clemmensen, Christoffer, Smajilovic, S., Madsen, A. N., Klein, A. B., Holst, Birgitte & Bräuner, Hans, 2013, In: Journal of Endocrinology. 217, 2, p. 151-60 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner, Hans, 2013, In: Amino Acids. 44, 2, p. 383-390 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function
Clemmensen, Christoffer, Smajilovic, S., Wellendorph, Petrine & Bräuner, Hans, 2014, In: British Journal of Pharmacology. 171, 5, p. 1129-1141Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor
Fischer, K., Finan, B., Clemmensen, Christoffer, van der Ploeg, L. H. T., Tschöp, M. H. & Müller, T. D., 2014, In: Frontiers in Nutrition. 1, p. 31Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
Clemmensen, Christoffer, Chabenne, J., Finan, B., Sullivan, L., Fischer, K., Küchler, D., Sehrer, L., Ograjsek, T., Hofmann, S. M., Schriever, S. C., Pfluger, P. T., Pinkstaff, J., Tschöp, M. H., Dimarchi, R. & Müller, T. D., Apr 2014, In: Diabetes. 63, 4, p. 1422-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress
Ryan, K. K., Mul, J. D., Clemmensen, Christoffer, Egan, A. E., Begg, D. P., Halcomb, K., Seeley, R. J., Herman, J. P. & Ulrich-Lai, Y. M., Apr 2014, In: Psychoneuroendocrinology. 42, p. 98-105 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, Christoffer, Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F. & Seeley, R. J., 8 May 2014, In: Nature. 509, 7499, p. 183-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists
Finan, B., Clemmensen, Christoffer & Müller, T. D., 2015, In: Molecular and Cellular Endocrinology. 418 Pt 1, p. 42-54 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, B., Yang, B., Ottaway, N., Smiley, D. L., Ma, T., Clemmensen, C., Chabenne, J., Zhang, L., Habegger, K. M., Fischer, K., Campbell, J. E., Sandoval, D., Seeley, R. J., Bleicher, K., Uhles, S., Riboulet, W., Funk, J., Hertel, C., Belli, S., Sebokova, E. & 9 others, , Jan 2015, In: Nature Medicine. 21, 1, p. 27-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases
Müller, T. D., Clemmensen, Christoffer, Finan, B., Dimarchi, R. D. & Tschöp, M. H., 1 Jan 2015, Leptin: Regulation and Clinical Applications. Springer, p. 267-279 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice
Clemmensen, Christoffer, Finan, B., Fischer, K., Tom, R. Z., Legutko, B., Sehrer, L., Heine, D., Grassl, N., Meyer, C. W., Henderson, B., Hofmann, S. M., Tschöp, M. H., Van der Ploeg, L. H. T. & Müller, T. D., Mar 2015, In: EMBO Molecular Medicine. 7, 3, p. 288-98 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease
Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., Fischer, K., Lutter, D., Sánchez-Garrido, M. A., Liu, P., Tuckermann, J., Malehmir, M., Healy, M. E., Weber, A., Heikenwalder, M., Jastroch, M. & 22 others, , 2016, In: Cell. 167, 3, p. 843-857.e1-e14 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
Current and Emerging Treatment Options in Diabetes Care
Clemmensen, Christoffer, Müller, T. D., Finan, B., Tschöp, M. H. & DiMarchi, R., 2016, Metabolic Control. Springer, Vol. 233. p. 437-459 23 p. (Handbook of Experimental Pharmacology; No. 233).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Hypothalamic leptin action is mediated by histone deacetylase 5
Kabra, D. G., Pfuhlmann, K., García-Cáceres, C., Schriever, S. C., Casquero García, V., Kebede, A. F., Fuente-Martin, E., Trivedi, C., Heppner, K., Uhlenhaut, N. H., Legutko, B., Kabra, U. D., Gao, Y., Yi, C-X., Quarta, C., Clemmensen, C., Finan, B., Müller, T. D., Meyer, C. W., Paez-Pereda, M. & 7 others, , 29 Feb 2016, In: Nature Communications. 7, 10782.Research output: Contribution to journal › Journal article › Research › peer-review
Reappraisal of GIP Pharmacology for Metabolic Diseases
Finan, B., Müller, T. D., Clemmensen, Christoffer, Perez-Tilve, D., DiMarchi, R. D. & Tschöp, M. H., May 2016, In: Trends in Molecular Medicine. 22, 5, p. 359-76 18 p.Research output: Contribution to journal › Review › Research › peer-review
Renaissance of leptin for obesity therapy
Quarta, C., Sánchez-Garrido, M. A., Tschöp, M. H. & Clemmensen, Christoffer, May 2016, In: Diabetologia. 59, 5, p. 920-7 8 p.Research output: Contribution to journal › Review › Research › peer-review
Unforeseen role for glucocorticoids in combinatorial anti-obesity pharmacology
Quarta, C. & Clemmensen, Christoffer, Jul 2016, In: Molecular Metabolism. 5, 7, p. 435-6 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Unimolecular Polypharmacy for Treatment of Diabetes and Obesity
Tschöp, M. H., Finan, B., Clemmensen, Christoffer, Gelfanov, V., Perez-Tilve, D., Müller, T. D. & DiMarchi, R. D., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 51-62 12 p.Research output: Contribution to journal › Review › Research › peer-review
Fibroblast activation protein (FAP) as a novel metabolic target
Sánchez-Garrido, M. A., Habegger, K. M., Clemmensen, Christoffer, Holleman, C., Müller, T. D., Perez-Tilve, D., Li, P., Agrawal, A. S., Finan, B., Drucker, D. J., Tschöp, M. H., DiMarchi, R. D. & Kharitonenkov, A., Oct 2016, In: Molecular Metabolism. 5, 10, p. 1015-24 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method
De Angelis, M., Giesert, F., Finan, B., Clemmensen, Christoffer, Müller, T. D., Vogt-Weisenhorn, D., Tschöp, M. H. & Schramm, K., 15 Oct 2016, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1033-1034, p. 413-420 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Emerging poly-agonists for obesity and type 2 diabetes
Kleinert, Maximilian, Clemmensen, Christoffer, Stemmer, K., Müller, T. D., DiMarchi, R. D. & Tschöp, M. H., 2017, In: Obesity. 25, 10, p. 1647-1649 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor
Clemmensen, Christoffer, Jørgensen, C. V., Smajilovic, S. & Bräuner, Hans, 2017, In: Diabetes, Obesity and Metabolism. 19, 4, p. 599-603Research output: Contribution to journal › Journal article › Research › peer-review
Gut-Brain Cross-Talk in Metabolic Control
Clemmensen, Christoffer, Müller, T. D., Woods, S. C., Berthoud, H., Seeley, R. J. & Tschöp, M. H., 23 Feb 2017, In: Cell. 168, 5, p. 758-774 17 p.Research output: Contribution to journal › Review › Research › peer-review
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, Christoffer, DiMarchi, R. D. & Tschöp, M. H., Apr 2017, In: Physiological Reviews. 97, 2, p. 721-766 46 p.Research output: Contribution to journal › Review › Research › peer-review
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
Fischer, K., Ruiz, H. H., Jhun, K., Finan, B., Oberlin, D. J., van der Heide, V., Kalinovich, A. V., Petrovic, N., Wolf, Y., Clemmensen, C., Shin, A. C., Divanovic, S., Brombacher, F., Glasmacher, E., Keipert, S., Jastroch, M., Nagler, J., Schramm, K-W., Medrikova, D., Collden, G. & 9 others, , May 2017, In: Nature Medicine. 23, 5, p. 623-630 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Jall, S., Sachs, S., Clemmensen, Christoffer, Finan, B., Neff, F., DiMarchi, R. D., Tschöp, M. H., Müller, T. D. & Hofmann, S. M., May 2017, In: Molecular Metabolism. 6, 5, p. 440-446 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
GLP-1/glucagon receptor co-agonism for treatment of obesity
Sánchez-Garrido, M. A., Brandt, S. J., Clemmensen, Christoffer, Müller, T. D., DiMarchi, R. D. & Tschöp, M. H., Oct 2017, In: Diabetologia. 60, 10, p. 1851-1861 11 p.Research output: Contribution to journal › Review › Research › peer-review
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity
Quarta, C., Clemmensen, C., Zhu, Z., Yang, B., Joseph, S. S., Lutter, D., Yi, C-X., Graf, E., García-Cáceres, C., Legutko, B., Fischer, K., Brommage, R., Zizzari, P., Franklin, B. S., Krueger, M., Koch, M., Vettorazzi, S., Li, P., Hofmann, S. M., Bakhti, M. & 16 others, , 3 Oct 2017, In: Cell Metabolism. 26, 4, p. 620-632.e6Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Animal models of obesity and diabetes mellitus
Kleinert, Maximilian, Clemmensen, Christoffer, Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., Bakhti, M., Klingenspor, M., Heiman, M., Cherrington, A. D., Ristow, M., Lickert, H., Wolf, E., Havel, P. J., Müller, T. D. & Tschöp, M. H., 2018, In: Nature Reviews Endocrinology. 14, p. 140-162 23 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Clemmensen, C., Jall, S., Kleinert, M., Quarta, C., Gruber, T., Reber, J., Sachs, S., Fischer, K., Feuchtinger, A., Karlas, A., Simonds, S. E., Grandl, G., Loher, D., Sanchez-Quant, E., Keipert, S., Jastroch, M., Hofmann, S. M., Nascimento, E. B. M., Schrauwen, P., Ntziachristos, V. & 4 others, , 2018, In: Nature Communications. 9, 13 p., 4304.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
Morville, T., Sahl, Ronni Eg, Trammell, Sam, Svenningsen, J. S., Gillum, M. P., Helge, Jørn Wulff & Clemmensen, Christoffer, 2018, In: JCI Insight. 3, 15, p. 1-13 e122737.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise increases circulating GDF15 in humans
Kleinert, Maximilian, Clemmensen, Christoffer, Sjøberg, K. A., Carl, Christian Strini, Jeppesen, J. F., Wojtaszewski, Jørgen F P, Kiens, Bente & Richter, Erik A., 2018, In: Molecular Metabolism. 9, p. 187-191 5 p.Research output: Contribution to journal › Letter › Research › peer-review
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs
Renner, S., Blutke, A., Dobenecker, B., Dhom, G., Müller, TD., Finan, B., Clemmensen, C., Bernau, M., Novak, I., Rathkolb, B., Senf, S., Zöls, S., Roth, M., Götz, A., M. Hofmann, S., Hrabě de Angelis, M., Wanke, R., Kienzl, E., M. Scholz, A., DiMarchi, R. D. & 3 others, , 2018, In: Molecular Metabolism. 16, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice
Kleinert, Maximilian, Kotzbeck, P., Altendorfer-Kroath, T., Birngruber, T., Tschöp, M. H. & Clemmensen, Christoffer, 2018, In: Molecular Metabolism. 13, p. 77-82 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Anti-Obesity Therapy: from Rainbow Pills to Polyagonists.
Müller, T., Clemmensen, Christoffer, Finan, B., DiMarchi, R. & Tschöp, M., Oct 2018, In: Pharmacological Reviews.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities
Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In: Drugs. 79, 11, p. 1187-1197 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of bariatric surgery on plasma GDF15 in humans
Kleinert, Maximilian, Bojsen-Møller, K. N., Jørgensen, N. B., Svane, M. S., Martinussen, C., Kiens, Bente, Wojtaszewski, Jørgen F P, Madsbad, Sten, Richter, Erik A. & Clemmensen, Christoffer, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E615-E621 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
Clemmensen, Christoffer, Finan, B., Müller, T. D., DiMarchi, R. D., Tschöp, M. H. & Hofmann, S. M., 2019, In: Nature Reviews Endocrinology. 15, p. 90-104Research output: Contribution to journal › Review › Research › peer-review
- Published
GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice
Decarie-Spain, L., Fisette, A., Zhu, Z., Yang, B., DiMarchi, R. D., Tschoep, M. H., Finan, B., Fulton, S. & Clemmensen, Christoffer, 2019, In: Neuropharmacology. 151, p. 55-63Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway
Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice
Jall, S., Finan, B., Collden, G., Fischer, K., Dong, X., Tschoep, M. H., Mueller, T. D. & Clemmensen, Christoffer, 2019, In: Molecular Metabolism. 23, p. 75-81Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unge forskere: S-løftebrud er en katastrofe for universiteterne
Aguirre, V., Andersen, C., Andersen, P. R., Bjørk, R., Clemmensen, C., Dalsgaard, P., Danbolt, M., Dimke, H., Engberg-Pedersen, A., Feliu, E., Jauffred, L., Jønsson, K., Kornum, B. R., Kropp, K., Laustsen, A., Levisen, C., Lock, N., Lomborg, S., Møller, N. M., Niss, K. & 5 others, , 2019Research output: Other contribution › Communication
- 2020
- Published
Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation
Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Nicolaisen, T. S., Carl, Christian Strini, Sjøberg, K. A., Raun, Steffen Henning, Klein, A. B., Sanchez-Quant, E., Langer, J., Ørskov, Cathrine, Clemmensen, Christoffer, Tschöp, M. H., Richter, Erik A., Kiens, Bente & Kleinert, Maximilian, 2020, In: Journal of Lipid Research. 61, 1, p. 10-19 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Muscarinic receptors in energy homeostasis: Physiology and pharmacology
Falk, S., Lund, Camilla & Clemmensen, Christoffer, 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Suppl. 6, p. 66-76 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity
Jall, S., De Angelis, M., Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Nicolaisen, T. S., Klein, A. B., Novikoff, A., Sachs, S., Richter, Erik A., Kiens, Bente, Schramm, K., Tschöp, M. H., Stemmer, K., Clemmensen, Christoffer, Müller, T. D. & Kleinert, Maximilian, 2020, In: Diabetologia. 63, 6, p. 1236-1247 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma Metabolome Profiling of Resistance Exercise and Endurance Exercise in Humans
Morville, T., Sahl, Ronni Eg, Moritz, Thomas, Helge, Jørn Wulff & Clemmensen, Christoffer, 2020, In: Cell Reports. 33, 13, 14 p., 108554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of Energy Excretion in Human Body Weight Regulation
Lund, Jens, Gerhart-Hines, Zach & Clemmensen, Christoffer, 2020, In: Trends in Endocrinology and Metabolism. 31, 10, p. 705-708 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
Fischer, K., Fenzl, A., Liu, D., Dyar, K. A., Kleinert, M., Brielmeier, M., Clemmensen, C., Fedl, A., Finan, B., Gessner, A., Jastroch, M., Huang, J., Keipert, S., Klingenspor, M., Brüning, J. C., Kneilling, M., Maier, F. C., Othman, A. E., Pichler, B. J., Pramme-Steinwachs, I. & 13 others, , 2020, In: Nature Communications. 11, 1, 13 p., 2306.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 16824492
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315
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GLP-1/glucagon receptor co-agonism for treatment of obesity
Research output: Contribution to journal › Review › Research › peer-review
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249
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Exercise increases circulating GDF15 in humans
Research output: Contribution to journal › Letter › Research › peer-review
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Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice
Research output: Contribution to journal › Letter › Research › peer-review
Published