Bo Torben Porse

Bo Torben Porse

Professor, Clinical Professor

Member of:

  • Internal Medicine: Haematology


  1. 2015
  2. Published

    Cellular origin of prognostic chromosomal aberrations in AML patients

    Mora-Jensen, H., Jendholm, L. J., Rapin, N. P. J., Andersen, M. K., Roug, A. S., Bagger, F. O., Bullinger, L., Winther, Ole, Borregaard, N., Porse, Bo Torben & Theilgaard-Mønch, Kim, 11 Feb 2015, In: Leukemia. 29, p. 1785-1789 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

    Paul, F., Arkin, Y., Giladi, A., Jaitin, D. A., Kenigsberg, E., Keren-Shaul, H., Winter, D., Lara-Astiaso, D., Gury, M., Weiner, A., David, E., Cohen, N., Lauridsen, F. K. B., Haas, S., Schlitzer, A., Mildner, A., Ginhoux, F., Jung, S., Trumpp, A., Porse, B. T. & 2 others, Tanay, A. & Amit, I., 17 Dec 2015, In: Cell. 163, 7, p. 1663-77 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    Rasmussen, K. D., Jia, G., Johansen, Jens Vilstrup, Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, Bo Torben, Bernard, O. A., Christensen, J. & Helin, K., 17 Apr 2015, In: Genes & Development. p. 910-922 13 p., 29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Disease evolution and outcomes in familial AML with germline CEBPA mutations

    Tawana, K., Wang, J., Renneville, A., Bödör, C., Hills, R., Loveday, C., Savic, A., Van Delft, F. W., Treleaven, J., Georgiades, P., Uglow, E., Asou, N., Uike, N., Debeljak, M., Jazbec, J., Ancliff, P., Gale, R., Thomas, X., Mialou, V., Döhner, K. & 21 others, Bullinger, L., Mueller, B., Pabst, T., Stelljes, M., Schlegelberger, B., Wozniak, E., Iqbal, S., Okosun, J., Araf, S., Frank, Anne-Katrine, Lauridsen, F. B., Porse, Bo Torben, Nerlov, C., Owen, C., Dokal, I., Gribben, J., Smith, M., Preudhomme, C., Chelala, C., Cavenagh, J. & Fitzgibbon, J., 3 Sep 2015, In: Blood. 126, 10, p. 1214-23 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia

    Willer, A., Jakobsen, J. S., Ohlsson, E., Rapin, N., Waage, J., Billing, M., Bullinger, L., Karlsson, S. & Porse, Bo Torben, 2015, In: Leukemia. 29, p. 1018-31 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: A critical role for IL-6/STAT3

    Xu, M., Feng, D., Wu, H., Wang, H., Chan, Y., Kolls, J., Borregaard, N., Porse, Bo Torben, Berger, T., Mak, T. W., Cowland, J. B., Kong, X. & Gao, B., Feb 2015, In: Hepatology. 61, 2, p. 692-702 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2014
  9. Published

    C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

    Hasemann, M. S., Lauridsen, F. K. B., Waage, J., Jakobsen, J. S., Frank, Anne-Katrine, Schuster, Mikkel Bruhn, Rapin, N. P. J., Bagger, F. O., Hoppe, P. S., Schroeder, T. & Porse, Bo Torben, Jan 2014, In: P L o S Genetics (Online). 10, 1, p. 1-10 10 p., e1004079.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Integrative analysis of histone ChIP-seq and transcription data using Bayesian mixture models

    Klein, H., Schäfer, M., Porse, Bo Torben, Hasemann, M. S., Ickstadt, K. & Dugas, M., 22 Jan 2014, In: Bioinformatics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner

    Norrie, I. C., Ohlsson, E., Nielsen, Olaf, Hasemann, M. S. & Porse, Bo Torben, 2014, In: P L o S One. 9, 1, p. 1-9 9 p., e84728.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Initiation of MLL-rearranged AML is dependent on C/EBPα

    Ohlsson, E., Hasemann, M. S., Willer, A., Lauridsen, F. K. B., Rapin, N. P. J., Jendholm, L. J. & Porse, Bo Torben, 13 Jan 2014, In: The Journal of Experimental Medicine. 211, 1, p. 5-13 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML

    Rapin, N. & Porse, Bo Torben, 2014, In: Oncogenesis. 3, p. 1-5 5 p., e106.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients

    Rapin, N. P. J., Bagger, F. O., Jendholm, L. J., Mora-Jensen, H., Krogh, Anders, Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, Ole, Theilgaard-Mønch, Kim & Porse, Bo Torben, 6 Feb 2014, In: Blood (online). 123, 6, p. 894-904 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

    Rishi, L., Hannon, M., Salomè, M., Hasemann, M., Frank, Anne-Katrine, Campos, J., Timoney, J., O'Connor, C., Cahill, M. R., Porse, Bo Torben & Keeshan, K., 10 Apr 2014, In: Blood. 123, 15, p. 2389-400 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    shRNA screening identifies JMJD1C as being required for leukemia maintenance

    Sroczynska, P., Cruickshank, V. A., Bukowski, J., Miyagi, S., Bagger, F. O., Walfridsson, J., Schuster, Mikkel Bruhn, Porse, Bo Torben & Helin, K., 5 Feb 2014, In: Blood (online).

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    spliceR: an R package for classification of alternative splicing and prediction of coding potential from RNA-seq data

    Vitting-Seerup, K., Porse, Bo Torben, Sandelin, Albin Gustav & Waage, J., 2014, In: B M C Bioinformatics. 15, p. 1-7 7 p., 81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2013
  19. Published

    HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

    Bagger, F. O., Rapin, N. P. J., Theilgaard-Mønch, Kim, Kaczkowski, B., Thorén, L. A. M., Jendholm, L. J., Winther, Ole & Porse, Bo Torben, 2013, In: Nucleic Acids Research. 41, Database issue, p. D1034-D1039 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

    Colak, D., Ji, S., Porse, Bo Torben & Jaffrey, S. R., 2013, In: Cell. 153, 6, p. 1252-65 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The functional consequences of intron retention: Alternative splicing coupled to NMD as a regulator of gene expression

    Ge, Y. & Porse, Bo Torben, 18 Dec 2013, In: BioEssays.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries

    Jakobsen, J. S., Waage, J., Rapin, N., Bisgaard, Hanne Cathrine, Larsen, F. S. & Porse, Bo Torben, Apr 2013, In: Genome Research. 23, 4, p. 592-603 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

    Leucci, E., Patella, F., Waage, J., Holmstrøm, K., Lindow, M., Porse, Bo Torben, Kauppinen, S. & Lund, Anders H., 29 Aug 2013, In: Scientific Reports. 3, p. 2535

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Improving The Analysis Of Gene Expression Profiles By Comparing AML Blasts With Their Nearest Normal Counterparts

    Rapin, N., Bagger, F. O., Jendholm, J., Mora-Jensen, H. I., Krogh, Anders, Kohlmann, A., Thiede, C., Borregaard, N., Bullinger, L., Winther, Ole, Theilgaard-Mønch, Kim & Porse, Bo Torben, 2013, In: Blood. 122, 21

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  25. Published

    Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors

    Schuster, Mikkel Bruhn, Frank, Anne-Katrine, Bagger, F. O., Rapin, N., Vikesaa, J. & Porse, Bo Torben, Oct 2013, In: Experimental Hematology. 41, 10, p. 882-893 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells

    Thoren, L. A., Fog, C. K., Jensen, K. T., Buza-Vidas, N., Côme, Christophe Roger Michel, Lund, Anders H. & Porse, Bo Torben, 9 Aug 2013, In: Stem Cell Research. 11, 3, p. 1129-1136 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2012
  28. Published

    BLUEPRINT to decode the epigenetic signature written in blood

    Adams, D., Altucci, L., Antonarakis, S. E., Ballesteros, J., Beck, S., Bird, A., Bock, C., Boehm, B., Campo, E., Caricasole, A., Dahl, F., Dermitzakis, E. T., Enver, T., Esteller, M., Estivill, X., Ferguson-Smith, A., Fitzgibbon, J., Flicek, P., Giehl, C., Graf, T. & 37 others, Grosveld, F., Guigo, R., Gut, I., Helin, K., Jarvius, J., Küppers, R., Lehrach, H., Lengauer, T., Lernmark, Å., Leslie, D., Loeffler, M., Macintyre, E., Mai, A., Martens, J. H. A., Minucci, S., Ouwehand, W. H., Pelicci, P. G., Pendeville, H., Porse, Bo Torben, Rakyan, V., Reik, W., Schrappe, M., Schübeler, D., Seifert, M., Siebert, R., Simmons, D., Soranzo, N., Spicuglia, S., Stratton, M., Stunnenberg, H. G., Tanay, A., Torrents, D., Valencia, A., Vellenga, E., Vingron, M., Walter, J. & Willcocks, S., 2012, In: Nature Biotechnology. 30, 3, p. 224-6 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  29. Published

    HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

    Bagger, F. O., Rapin, N. P. J., Theilgaard-Mønch, Kim, Kaczkowski, B., Jendholm, L. J., Winther, O. & Porse, Bo Torben, 2012, In: Blood. 119, 26, p. 6394-6395 2 p.

    Research output: Contribution to journalComment/debateResearch

  30. Published

    Phosphorylation of Serine 248 of C/EBPa Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

    Hasemann, M. S., Schuster, Mikkel Bruhn, Frank, Anne-Katrine, Theilgaard-Mønch, Kim, Pedersen, T. Å., Nerlov, C. & Porse, Bo Torben, 2012, In: P L o S One. 7, 6, p. e38841

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML

    Treppendahl, M. B., Qiu, X., Søgaard, A., Yang, X., Nandrup-Bus, C., Hother, C., Andersen, M. K., Kjeldsen, L., Möllgård, L., Möllgaard, L., Hellström-Lindberg, E., Jendholm, L. J., Porse, Bo Torben, Jones, P. A., Liang, G. & Grønbæk, Kirsten, 5 Jan 2012, In: Blood. 119, 1, p. 206-16 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

    Weischenfeldt, Joachim Lütken, Waage, J. E., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, Karsten, Krogh, Anders, Wang, J. & Porse, Bo Torben, 2012, In: Genome Biology (Online Edition). 13, 5, 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

    Zheng, S., Gray, E. E., Chawla, G., Porse, Bo Torben, O'Dell, T. J. & Black, D. L., Mar 2012, In: Nature Neuroscience. 15, 3, p. 381-8, S1

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2011
  35. Published

    Immunophenotypical characterization of human neutrophil differentiation

    Jensen, H. M., Jendholm, J., Fossum, A., Porse, Bo Torben, Borregaad, N. & Theilgaard-Mønch, Kim, 7 Jun 2011, In: Journal of Leukocyte Biology. p. 629-634 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Technical advance: immunophenotypical characterization of human neutrophil differentiation

    Mora-Jensen, H. I., Jendholm, J., Fossum, A., Porse, Bo Torben, Borregaard, N. & Theilgaard-Mönch, K., 2011, In: Journal of Leukocyte Biology. 90, 3, p. 629-34 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Gene expression profiling in MDS and AML: potential and future avenues

    Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A., Morgan, M., Porse, B., Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K., Bullinger, L., Theilgaard-Mönch, K., Boultwood, J., Ferrari, S., Giannopoulos, K., Hernandez-Rivas, J. M., Kohlmann, A. & 8 others, Morgan, M., Porse, Bo Torben, Tagliafico, E., Zwaan, C. M., Wainscoat, J., Van den Heuvel-Eibrink, M. M., Mills, K. & Bullinger, L., 2011, In: Leukemia. 25, 6, p. 909-20 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2010
  39. Published

    A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia

    Marstrand, T. T., Borup, R., Willer, A., Borregaard, N., Sandelin, Albin Gustav, Porse, Bo Torben & Theilgaard-Mønch, Kim, Jul 2010, In: Leukemia. 24, 7, p. 1265-75 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

    Pasini, D., Malatesta, M., Jung, H. R., Valfridsson, J. O. A., Willer, A., Olsson, L., Skotte, J., Wutz, A., Porse, Bo Torben, Jensen, O. N. & Helin, K., Aug 2010, In: Nucleic Acids Research. 38, 15, p. 4958-69 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Basal stamcellebiologi og cancer

    Porse, Bo Torben, Petersen, Ole William & Helin, K., 20 Sep 2010, In: Ugeskrift for læger. 172, 38, p. 2600-3 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    UPF2 is a critical regulator of liver development, function and regeneration

    Thoren, L. A., Nørgaard, G. A., Weischenfeldt, Joachim Lütken, Waage, J., Jakobsen, J. S., Damgaard, I., Bergström, F. C., Blom, A. M., Borup, R., Bisgaard, Hanne Cathrine & Porse, Bo Torben, 2010, In: PLoS ONE. 5, 7, p. e11650

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Lipocalin 2 is protective against E. coli pneumonia

    Wu, H., Santoni-Rugiu, E., Ralfkiaer, E., Porse, Bo Torben, Moser, Claus Ernst, Høiby, Niels, Borregaard, N. & Cowland, J. B., 2010, In: Respiratory research. 11, p. 96

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Lipocalin 2 is protective against E. coli pneumonia

    Wu, H., Santoni Rugiu, Eric, Ralfkiaer, E., Porse, Bo Torben, Moser, C., Høiby, Niels, Borregaard, N., Cowland, J. B., Wu, H., Santoni Rugiu, Eric, Ralfkiær, E., Porse, B. T., Moser, C. E., Høiby, N., Borregaard, N. & Cowland, J., 15 Jun 2010, In: Respiratory research (Online). 11, 96, 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2009
  46. Published

    Leukemia - methods and protocols

    Porse, Bo Torben, 2009, In: European Journal of Haematology. 84, 1, p. 94

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    C/EBPalpha in leukemogenesis: Identity and origin of the leukemia-initiating cell

    Schuster, Mikkel Bruhn & Porse, Bo Torben, 2009, In: BioFactors. 35, 3, p. 227-31 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2008
  49. Published

    Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

    Christoffersen, C., Jauhiainen, M., Moser, M., Porse, Bo Torben, Ehnholm, C., Boesl, M., Dahlback, B. & Nielsen, L. B., 2008, In: Journal of Biological Chemistry. 283, 4, p. 1839-1847 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

    Christoffersen, Christina, Jauhiainen, M., Moser, M., Porse, Bo Torben, Ehnholm, C., Boesl, M., Dahlbäck, B. & Nielsen, L. B., 25 Jan 2008, In: The Journal of Biological Chemistry. 283, 4, p. 1839-47 9 p.

    Research output: Contribution to journalJournal articleResearch

  51. Published

    Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.

    Hasemann, M. S., Damgaard, I., Schuster, Mikkel Bruhn, Theilgaard-Mønch, Kim, Sørensen, A. B., Mrsic, A., Krugers, T., Ylstra, B., Pedersen, F. S., Nerlov, C. & Porse, Bo Torben, 2008, In: Blood. 111, 8, p. 4309-21 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

    Kirstetter, P., Schuster, Mikkel Bruhn, Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Mønch, Kim, Månsson, R., Pedersen, T. A., Pabst, T., Schrock, E., Porse, Bo Torben, Jacobsen, S. E. W., Bertone, P., Tenen, D. G. & Nerlov, C., 2008, In: Cancer Cell. 13, 4, p. 299-310 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Bone Marrow-derived Macrophages (BMMs): Isolation and applications.

    Weischenfeldt, Joachim Lütken & Porse, Bo Torben, 2008, In: Cold Spring Harbor Protocols.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.

    Weischenfeldt, Joachim Lütken, Damgaard, I., Bryder, D., Theilgaard-Mønch, Kim, Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C. & Porse, Bo Torben, 2008, In: Genes & Development. 22, 10, p. 1381-96 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2007
  56. Published

    The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

    Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mønch, Kim, Minucci, S., Porse, Bo Torben, Marine, J., Hansen, K. H. & Helin, K., 2007, In: Genes & Development. 21, 5, p. 525-30 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.

    Pedersen, T. A., Bereshchenko, O., Garcia-Silva, S., Ermakova, O., Kurz, E., Mandrup, S., Porse, Bo Torben & Nerlov, C., 2007, In: EMBO Journal. 26, 4, p. 1081-93 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2006
  59. Published

    Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

    Kirstetter, P., Anderson, K., Porse, Bo Torben, Jacobsen, S. E. W. & Nerlov, C., 2006, In: Nature Immunology. 7, 10, p. 1048-56 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.

    Porse, Bo Torben, Pedersen, T. A., Hasemann, M. S., Schuster, Mikkel Bruhn, Kirstetter, P., Luedde, T., Damgaard, I., Kurz, E., Schjerling, C. K. & Nerlov, C., 2006, In: Molecular and Cellular Biology. 26, 3, p. 1028-37 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4985646