Anne-Vibeke Lænkholm

Anne-Vibeke Lænkholm

Clinical Associate Professor


  1. 2023
  2. Published

    Neo-train: study protocol and feasibility results for a two-arm randomized controlled trial investigating the effect of supervised exercise during neoadjuvant chemotherapy on tumour response in patients with breast cancer

    Kjeldsted, E., Ammitzbøll, G., Jørgensen, L. B., Lodin, A., Bojesen, R. D., Ceballos, S. G., Rosthøj, Susanne, Lænkholm, Anne-Vibeke, Skou, S. T., Jack, S., Gehl, Julie & Dalton, Susanne Oksbjerg, Dec 2023, In: BMC Cancer. 23, 1, 777.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics

    Weitz, P., Valkonen, M., Solorzano, L., Carr, C., Kartasalo, K., Boissin, C., Koivukoski, S., Kuusela, A., Rasic, D., Feng, Y., Pouplier, S. S., Sharma, A., Ledesma Eriksson, K., Latonen, L., Lænkholm, Anne-Vibeke, Hartman, J., Ruusuvuori, P. & Rantalainen, M., 2023, In: Scientific Data. 10, 6 p., 562.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Adjuvant chemotherapy in patients with ER-negative/HER2-negative, T1abN0 breast cancer: a nationwide study

    Hassing, C. M. S., Mejdahl, M. K., Lænkholm, Anne-Vibeke, Kroman, Niels Thorndahl, Knoop, A. S. & Tvedskov, Tove Filtenborg, 2023, In: Breast Cancer Research and Treatment. 198, 1, p. 103-112 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Adjuvant treatment with trastuzumab of patients with HER2-positive, T1a-bN0M0 breast tumors: A systematic review and meta-analysis

    Hassing, C. M. S., Nielsen, Dorte Lisbet, Knoop, A. S., Tvedskov, Tove Filtenborg, Kroman, Niels Thorndahl, Lænkholm, Anne-Vibeke, Juhl, C. B. & Kümler, Iben, 2023, In: Critical Reviews in Oncology/Hematology. 184, 11 p., 103952.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Calcium electroporation as an adjunct therapy for pembrolizumab-resistant bladder cancer: a case report

    Vissing, M., Munch Larsen, L., Christensen, A. J., Öwall, L., Sinius Pouplier, S., Lænkholm, Anne-Vibeke & Gehl, Julie, 2023, In: Acta Oncologica. 62, 6, p. 614-620 7 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  7. Published

    Digital image analysis and assisted reading of the HER2 score display reduced concordance: pitfalls in the categorisation of HER2-low breast cancer

    Sode, M., Thagaard, J., Eriksen, J. O. & Lænkholm, Anne-Vibeke, 2023, In: Histopathology. 82, 6, p. 912-924 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness

    Andersen, L. V. B., Larsen, M. J., Davies, H., Degasperi, A., Nielsen, H. R., Jensen, L. A., Kroeldrup, L., Gerdes, Anne-Marie Axø, Lænkholm, Anne-Vibeke, Kruse, T. A., Nik-Zainal, S. & Thomassen, M., 2023, In: Breast Cancer Research. 25, 1, 10 p., 69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

    Cserni, B., Kilmartin, D., O’Loughlin, M., Andreu, X., Bagó-Horváth, Z., Bianchi, S., Chmielik, E., Figueiredo, P., Floris, G., Foschini, M. P., Kovács, A., Heikkilä, P., Kulka, J., Laenkholm, A. V., Liepniece-Karele, I., Marchiò, C., Provenzano, E., Regitnig, P., Reiner, A., Ryška, A. & 17 others, Sapino, A., Stovgaard, E. S., Quinn, C., Zolota, V., Webber, M., Glynn, S. A., Bori, R., Csörgő, E., Oláh-Németh, O., Pancsa, T., Sejben, A., Sejben, I., Vörös, A., Zombori, T., Nyári, T., Callagy, G. & Cserni, G., 2023, In: Cancers. 15, 4, 11 p., 1199.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    PROCURE European consensus on breast cancer multigene signatures in early breast cancer management

    Curigliano, G., Cardoso, F., Gnant, M., Harbeck, N., King, J., Lænkholm, Anne-Vibeke, Penault-Llorca, F. & Prat, A., 2023, In: npj Breast Cancer. 9, 8 p., 8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: a report of the international immuno-oncology biomarker working group

    Thagaard, J., Broeckx, G., Page, D. B., Jahangir, C. A., Verbandt, S., Kos, Z., Gupta, R., Khiroya, R., Abduljabbar, K., Acosta Haab, G., Acs, B., Akturk, G., Almeida, J. S., Alvarado-Cabrero, I., Amgad, M., Azmoudeh-Ardalan, F., Badve, S., Baharun, N. B., Balslev, E., Bellolio, E. R. & 122 others, Bheemaraju, V., Blenman, K. R. M., Botinelly Mendonça Fujimoto, L., Bouchmaa, N., Burgues, O., Chardas, A., Chon U Cheang, M., Ciompi, F., Cooper, L. A. D., Coosemans, A., Corredor, G., Dahl, A. B., Dantas Portela, F. L., Deman, F., Demaria, S., Doré Hansen, J., Dudgeon, S. N., Ebstrup, T., Elghazawy, M., Fernandez-Martín, C., Fox, S. B., Gallagher, W. M., Giltnane, J. M., Gnjatic, S., Gonzalez-Ericsson, P. I., Grigoriadis, A., Halama, N., Hanna, M. G., Harbhajanka, A., Hart, S. N., Hartman, J., Hauberg, S., Hewitt, S., Hida, A. I., Horlings, H. M., Husain, Z., Hytopoulos, E., Irshad, S., Janssen, E. A. M., Kahila, M., Kataoka, T. R., Kawaguchi, K., Kharidehal, D., Khramtsov, A. I., Kiraz, U., Kirtani, P., Kodach, L. L., Korski, K., Kovács, A., Lænkholm, Anne-Vibeke, Lang-Schwarz, C., Larsimont, D., Lennerz, J. K., Lerousseau, M., Li, X., Ly, A., Madabhushi, A., Maley, S. K., Manur Narasimhamurthy, V., Marks, D. K., McDonald, E. S., Mehrotra, R., Michiels, S., Minhas, F. U. A. A., Mittal, S., Moore, D. A., Mushtaq, S., Nighat, H., Papathomas, T., Penault-Llorca, F., Perera, R. D., Pinard, C. J., Pinto-Cardenas, J. C., Pruneri, G., Pusztai, L., Rahman, A., Rajpoot, N. M., Rapoport, B. L., Rau, T. T., Reis-Filho, J. S., Ribeiro, J. M., Rimm, D., Roslind, A., Vincent-Salomon, A., Salto-Tellez, M., Saltz, J., Sayed, S., Scott, E., Siziopikou, K. P., Sotiriou, C., Stenzinger, A., Sughayer, M. A., Sur, D., Fineberg, S., Symmans, F., Tanaka, S., Taxter, T., Tejpar, S., Teuwen, J., Thompson, E. A., Tramm, T., Tran, W. T., van der Laak, J., van Diest, P. J., Verghese, G. E., Viale, G., Vieth, M., Wahab, N., Walter, T., Waumans, Y., Wen, H. Y., Yang, W., Yuan, Y., Zin, R. M., Adams, S., Bartlett, J., Loibl, S., Denkert, C., Savas, P., Loi, S., Salgado, R. & Specht Stovgaard, E., 2023, In: Journal of Pathology. 260, 5, p. 498-513 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. 2022
  13. Published

    Benefit of adjuvant chemotherapy and trastuzumab in patients with HER2-positive, node-negative breast tumors ≤ 10 mm: a nationwide study

    Hassing, C. M. S., Mejdahl, M. K., Lænkholm, Anne-Vibeke, Kroman, Niels Thorndahl, Knoop, A. S. & Tvedskov, Tove Filtenborg, 2022, In: Breast Cancer Research and Treatment. 196, 1, p. 197-206

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Capsulectomy Can Successfully Treat Chronic Encapsulated Breast Seroma: A Case Report

    Fosheim, K., Bojesen, S., Troestrup, H. & Lænkholm, Anne-Vibeke, 2022, In: Cureus. 14, 1, 5 p., e21677.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Incorporation of TILs in daily breast cancer care: how much evidence can we bear?

    Lænkholm, Anne-Vibeke, Callagy, G., Balancin, M., Bartlett, J. M. S., Sotiriou, C., Marchio, C., Kok, M., Dos Anjos, C. H. & Salgado, R., 2022, In: Virchows Archiv. 480, 1, p. 147-162 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Inter-observer agreement of tumor infiltrating lymphocytes in primary HER2-positive breast cancer and correlation between tissue microarray and full tumor-sections

    Reznitsky, F. M., Jensen, J. D., Knoop, A. & Lænkholm, Anne-Vibeke, 2022, In: APMIS. 130, 9, p. 545-550

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Neither Tumor-Infiltrating Lymphocytes nor Cytotoxic T Cells Predict Enhanced Benefit from Chemotherapy in the DBCG77B Phase III Clinical Trial

    Shenasa, E., Stovgaard, Elisabeth Ida Specht, Jensen, M. B., Asleh, K., Riaz, N., Gao, D., Leung, S., Ejlertsen, Bent Laursen, Lænkholm, Anne-Vibeke & Nielsen, T. O., 2022, In: Cancers. 14, 15, 14 p., 3808.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

    Acs, B. & on behalf of the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group (BIG-NABCG), O. B. O. T. I. K. I. B. C. W. G. O. T. B. I. G. A. N. A. B. C. G. (., 2022, In: Modern Pathology. 35, 10, p. 1362-1369 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2021
  20. Published

    Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer

    Jørgensen, N., Hviid, Thomas Vauvert F., Nielsen, L. B., Sønderstrup, I. M. H., Eriksen, J. O., Ejlertsen, Bent Laursen, Gerdes, Anne-Marie Axø, Kruse, T. A., Thomassen, M., Jensen, M. & Lænkholm, Anne-Vibeke, Aug 2021, In: British Journal of Cancer. 125, p. 1388–1398

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

    Løkkegaard, S., Elias, D., Alves, C. L., Bennetzen, M. V., Lænkholm, Anne-Vibeke, Bak, M., Gjerstorff, M. F., Johansen, L. E., Vever, H., Bjerre, C., Kirkegaard, T., Nordenskjöld, B., Fornander, T., Stål, O., Lindström, L. S., Esserman, L. J., Lykkesfeldt, A. E., Andersen, J. S., Leth-Larsen, R. & Ditzel, H. J., 4 Jan 2021, In: npj Breast Cancer. 7, 1, p. 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Assessment of Ki67 in Breast Cancer: Updated Recommendations from the International Ki67 in Breast Cancer Working Group

    Nielsen, T. O., Leung, S. C. Y., Rimm, D. L., Dodson, A., Acs, B., Badve, S., Denkert, C., Ellis, M. J., Fineberg, S., Flowers, M., Kreipe, H. H., Laenkholm, A-V., Pan, H., Penault-Llorca, F. M., Polley, M-Y., Salgado, R., Smith, I. E., Sugie, T., Bartlett, J. M. S., McShane, L. M. & 2 others, Dowsett, M. & Hayes, D. F., 2021, In: JNCI - Journal of the National Cancer Institute. 113, 7, p. 808–819

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Intra-tumour heterogeneity is one of the main sources of inter-observer variation in scoring stromal tumour infiltrating lymphocytes in triple negative breast cancer

    Kilmartin, D., O’Loughlin, M., Andreu, X., Bagó-Horváth, Z., Bianchi, S., Chmielik, E., Cserni, G., Figueiredo, P., Floris, G., Foschini, M. P., Kovács, A., Heikkilä, P., Kulka, J., Laenkholm, A. V., Liepniece-Karele, I., Marchiò, C., Provenzano, E., Regitnig, P., Reiner, A., Ryška, A. & 8 others, Sapino, A., Stovgaard, E. S., Quinn, C., Zolota, V., Webber, M., Roshan, D., Glynn, S. A. & Callagy, G., 2021, In: Cancers. 13, 17, 4410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Peripheral blood immune markers in breast cancer: Differences in regulatory T cell abundance are related to clinical parameters

    Jørgensen, N., Lænkholm, Anne-Vibeke, Sækmose, S. G., Hansen, Lone Bak & Hviid, Thomas Vauvert F., 2021, In: Clinical Immunology. 232, 12 p., 108847.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The immune microenvironment and relation to outcome in patients with advanced breast cancer treated with docetaxel with or without gemcitabine

    Stovgaard, E. S., Asleh, K., Riaz, N., Leung, S., Gao, D., Nielsen, L. B., Lænkholm, Anne-Vibeke, Balslev, E., Jensen, M. B., Nielsen, D. & O Nielsen, T., 2021, In: OncoImmunology. 10, 1, 11 p., 1924492.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

    El Bairi, K., Haynes, H. R., Blackley, E., Fineberg, S., Shear, J., Turner, S., de Freitas, J. R., Sur, D., Amendola, L. C., Gharib, M., Kallala, A., Arun, I., Azmoudeh-Ardalan, F., Fujimoto, L., Sua, L. F., Liu, S. W., Lien, H. C., Kirtani, P., Balancin, M., El Attar, H. & 31 others, Guleria, P., Yang, W., Shash, E., Chen, I. C., Bautista, V., Do Prado Moura, J. F., Rapoport, B. L., Castaneda, C., Spengler, E., Acosta-Haab, G., Frahm, I., Sanchez, J., Castillo, M., Bouchmaa, N., Md Zin, R. R., Shui, R., Onyuma, T., Yang, W., Husain, Z., Willard-Gallo, K., Coosemans, A., Perez, E. A., Provenzano, E., Choi, H. J., Lænkholm, Anne-Vibeke, Stovgaard, Elisabeth Ida Specht, Nielsen, T., Balslev, E., Sharma, A., Garbyal, Rajendra Singh & The International Immuno-Oncology Biomarker Working Group, T. I. I. B. W. G., 2021, In: npj Breast Cancer. 7, 1, 17 p., 150.

    Research output: Contribution to journalReviewResearchpeer-review

  27. 2020
  28. Published

    Breast cancer survival in Nordic BRCA2 mutation carriers-unconventional association with oestrogen receptor status

    Olafsdottir, E. J., Borg, A., Jensen, M., Gerdes, Anne-Marie Axø, Johansson, A. L. V., Barkardottir, R. B., Johannsson, O. T., Ejlertsen, Bent Laursen, Sønderstrup, I. M. H., Hovig, E., Lænkholm, Anne-Vibeke, Hansen, T. V. O., Olafsdottir, G. H., Rossing, M., Jonasson, J. G., Sigurdsson, S., Loman, N., Nilsson, M. P., Narod, S. A. & Tryggvadottir, L., Nov 2020, In: British Journal of Cancer. 123, 11, p. 1608-1615 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    How current assay approval policies are leading to unintended imprecision medicine

    Salgado, R., Bellizzi, A. M., Rimm, D., Bartlett, J. M. S., Nielsen, T., Holger, M., Lænkholm, Anne-Vibeke, Quinn, C., Cserni, G., Cunha, I. W., Alvarado-Cabrero, I. & Cree, I., Nov 2020, In: Lancet Oncology. 21, 11, p. 1399-1401 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

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