Mikkel-Ole Skjødt

Mikkel-Ole Skjødt

Associate Professor


  1. 2024
  2. Published

    Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens

    Götz, M. P., Villegas, M. A. D., Fageräng, B., Kerfin, A., Skjødt, Mikkel-Ole, Garred, Peter & Rosbjerg, Anne, 2024, In: Journal of Immunology. 212, 9, p. 1493-1503

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2023
  4. Published

    Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

    Cyranka, L., Mariegaard, I., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Mollnes, T. E., Garred, Peter & Rosbjerg, A., 2023, In: Journal of Innate Immunity. 15, 1, p. 836-849

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19

    Götz, M. P., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Hansen, Cecilie Bo, Pérez-Alós, L., Jarlhelt, I., Benfield, Thomas, Rosbjerg, Anne & Garred, Peter, 2023, In: Journal of Innate Immunity. 15, 1, p. 122–135

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2021
  7. Published

    Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Hansen, Cecilie Bo, Jarlhelt, I., Hasselbalch, R. B., Hamm, S. R., Fogh, K., Pries-Heje, M. M., Møller, D. L., Heftdal, Line Dam, Pérez-Alós, L., Sørensen, E., Larsen, M. A. H., Skjødt, Mikkel-Ole, Ostrowski, Sisse Rye, Frikke-Schmidt, Ruth, Bayarri-Olmos, R., Hilsted, Linda, Bundgård, Henning, Nielsen, Susanne Dam, Iversen, Kasper & Garred, Peter, 2021, In: Journal of Internal Medicine. 290, 6, p. 1272-1274

    Research output: Contribution to journalLetterResearchpeer-review

  8. Published

    Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants

    Bayarri-Olmos, R., Jarlhelt, I., Johnsen, L. B., Hansen, Cecilie Bo, Helgstrand, C., Rose Bjelke, J., Matthiesen, F., Nielsen, Susanne Dam, Iversen, Kasper, Ostrowski, Sisse Rye, Bundgård, Henning, Frikke-Schmidt, Ruth, Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Frontiers in Immunology. 12, 757197.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    MASP-1 and MASP-3 bind directly to aspergillus fumigatus and promote complement activation and phagocytosis

    Rosbjerg, Anne, Würzner, R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Innate Immunity. 13, 4, p. 211-224 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Reply to Lassaunière: On the functional characterization of the Y453F RBD variant found in cluster 5 SARS-CoV-2

    Bayarri-Olmos, R., Johnsen, L. B., Rosbjerg, Anne, Helgstrand, C., Bak-Thomsen, T., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Biological Chemistry. 297, 5, 101241.

    Research output: Contribution to journalLetterResearch

  11. Published

    SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation

    Jarlhelt, I., Nielsen, S. K., Jahn, C. X. H., Hansen, Cecilie Bo, Pérez-Alós, L., Rosbjerg, A., Bayarri-Olmos, R., Skjødt, Mikkel-Ole & Garred, Peter, 2021, In: Frontiers in Immunology. 12, 11 p., 767981.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    SARS-CoV-2 antibody responses are correlated to disease severity in COVID-19 convalescent individuals

    Hansen, Cecilie Bo, Jarlhelt, I., Pérez-Alós, L., Landsy, L. H., Loftager, M., Rosbjerg, Anne, Helgstrand, C., Bjelke, J. R., Egebjerg, T., Jardine, J. G., Jørgensen, C. S., Iversen, Kasper, Bayarri-Olmos, R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Immunology. 206, 1, p. 109-117 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    SARS-CoV-2 neutralizing antibody responses towards full-length spike protein and the receptor-binding domain

    Bayarri-Olmos, R., Idorn, M., Rosbjerg, A., Pérez-Alós, L., Hansen, Cecilie Bo, Johnsen, L. B., Helgstrand, C., Zosel, F., Bjelke, J. R., Öberg, F. K., Søgaard, M., Paludan, S. R., Bak-Thomsen, T., Jardine, J. G., Skjødt, Mikkel-Ole & Garred, Peter, 2021, In: Journal of Immunology. 207, 3, p. 878-887 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization

    Bayarri-Olmos, R., Rosbjerg, Anne, Johnsen, L. B., Helgstrand, C., Bak-Thomsen, T., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Biological Chemistry. 296, A13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

    Bayarri-Olmos, R., Johnsen, L. B., Idorn, M., Reinert, L. S., Rosbjerg, Anne, Vang, S., Hansen, Cecilie Bo, Helgstrand, C., Bjelke, J. R., Bak-Thomsen, T., Paludan, S. R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: eLife. 10, 14 p., e70002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2019
  17. Published

    Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade

    Pérez-Alós, L., Bayarri-Olmos, R., Skjødt, Mikkel-Ole & Garred, Peter, 2019, In: F A S E B Journal. 33, 11, p. 12723-12734 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    THE PATTERN RECOGNITION MOLECULES MBL AND C1Q DETACH FROM THEIR PATHOGEN LIGANDS UPON COMPLEMENT ACTIVATION

    Rosbjerg, Anne, Garred, Peter & Skjødt, Mikkel-Ole, 2019, In: Molecular Immunology. 114, p. 490-490

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  19. 2018
  20. Published

    Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

    Hertz, C. E., Bayarri-Olmos, R., Kirketerp-Møller, N., van Putten, S., Pilely, K., Skjødt, Mikkel-Ole & Garred, Peter, 2018, In: Frontiers in Immunology. 9, 13 p., 1945.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)

    Bayarri-Olmos, R., Kirketerp-Moller, N., Pérez-Alós, L., Skjodt, K., Skjødt, Mikkel-Ole & Garred, Peter, 2018, In: Frontiers in Immunology. 9, 14 p., 2238.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2017
  23. Published

    C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques

    Pilely, K., Fumagalli, S., Rosbjerg, A., Genster, N., Skjødt, Mikkel-Ole, Perego, C., Ferrante, A. M. R., De Simoni, M. & Garred, Peter, 2017, In: Frontiers in Immunology. 8, 14 p., 1040.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2016
  25. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury

    Ozaki, M., Kang, Y., Tan, Y. S., Pavlov, V. I., Liu, B., Boyle, D. C., Kushak, R. I., Skjødt, Mikkel-Ole, Grabowski, E. F., Taira, Y. & Stahl, G. L., Oct 2016, In: Kidney International. 90, 4, p. 774-782 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

    Kozarcanin, H., Lood, C., Fog, L. M., Sandholm, K., Hamad, O. A., Bengtsson, A. A., Skjødt, Mikkel-Ole, Huber-Lang, M., Garred, Peter, Ekdahl, K. N. & Nilsson, B., Mar 2016, In: Journal of Thrombosis and Haemostasis. 14, 3, p. 531-545 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2015
  28. Published

    Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways

    Nordmaj, Mie Anemone, Munthe-Fog, L., Hein, E., Skjødt, Mikkel-Ole & Garred, Peter, Dec 2015, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 12, p. 4945-55 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema

    Hansen, C. B., Csuka, D., Munthe-Fog, L., Varga, L., Farkas, H., Hansen, K. M., Koch, C., Skjødt, K., Garred, Peter & Skjødt, Mikkel-Ole, 15 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 8, p. 3596-604 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway

    Ma, Y. J., Hein, E., Munthe-Fog, L., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Romani, L. & Garred, Peter, 1 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3365-73 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency

    Bay, J. T., Katzenstein, T. L., Kofoed, K., Patel, D., Skjødt, Mikkel-Ole, Garred, Peter & Schejbel, L., Oct 2015, In: Clinical Immunology. 160, 2, p. 315-8 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

  32. Published

    Pentraxin-3 level at admission is a strong predictor of short-term mortality in a community-based hospital setting

    Bastrup-Birk, S., Munthe-Fog, L., Skjødt, Mikkel-Ole, Ma, Y. J., Nielsen, H., Køber, Lars Valeur, Nielsen, Olav Wendelboe, Iversen, Kasper & Garred, Peter, May 2015, In: Journal of Internal Medicine. 277, 5, p. 562-572 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus

    Hein, E., Nielsen, L. A., Nielsen, C. T., Munthe-Fog, L., Skjødt, Mikkel-Ole, Jacobsen, Søren & Garred, Peter, Feb 2015, In: Molecular Immunology. 63, 2, p. 209-214 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2014
  35. Published

    A specific assay for quantification of human C4c by use of an anti-C4c monoclonal antibody

    Pilely, K., Skjødt, Mikkel-Ole, Nielsen, C., Andersen, T. E., Louise Aabom, A., Vitved, L., Koch, C., Skjødt, K. & Palarasah, Y., Mar 2014, In: Journal of Immunological Methods. 405, p. 87-96 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Defining the complement biomarker profile of C3 glomerulopathy

    Zhang, Y., Nester, C. M., Martin, B., Skjødt, Mikkel-Ole, Meyer, N. C., Shao, D., Borsa, N., Palarasah, Y. & Smith, R. J. H., 2014, In: Clinical Journal of American Society of Nephrology. . 9, 11, p. 1876-82 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Heterocomplex Formation between MBL/Ficolin/CL-11–Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11–Associated Protein-1

    Rosbjerg, A., Munthe-Fog, L., Garred, Peter & Skjødt, Mikkel-Ole, 2014, In: Journal of immunology (Baltimore, Md. : 1950). 192, 9, p. 4352-60 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2013
  39. Published

    Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

    Bastrup-Birk, S., Skjødt, Mikkel-Ole, Munthe-Fog, L., Strom, J. J., Ma, Y. J. & Garred, Peter, Sep 2013, In: P L o S One. 8, 9, p. 1-9 9 p., e73119.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study

    Schoos, M. M., Munthe-Fog, L., Skjødt, Mikkel-Ole, Ripa, Rasmus Sejersten, Lønborg, Jacob Thomsen, Kastrup, J., Kelbæk, H., Clemmensen, P. & Garred, Peter, Jul 2013, In: Molecular Immunology. 54, 3-4, p. 408-14 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    A novel assay to quantitate MASP-2/ficolin-3 complexes in serum

    Csuka, D., Munthe-Fog, L., Skjødt, Mikkel-Ole, Hein, E., Bay, Jakob Thaning, Varga, L., Füst, G. & Garred, Peter, 2013, In: Journal of Immunological Methods. 387, 1-2, p. 237-44 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure

    Prohászka, Z., Munthe-Fog, L., Ueland, T., Gombos, T., Yndestad, A., Förhécz, Z., Skjødt, Mikkel-Ole, Pozsonyi, Z., Gustavsen, A., Jánoskuti, L., Karádi, I., Gullestad, L., Dahl, C. P., Askevold, E. T., Füst, G., Aukrust, P., Mollnes, T. E. & Garred, Peter, 2013, In: P L o S One. 8, 4, p. 1-9 9 p., e60976.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex

    Ma, Y. J., Skjødt, Mikkel-Ole & Garred, Peter, 2013, In: Journal of Innate Immunity. 5, 3, p. 242-250 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency

    Csuka, D., Munthe-Fog, L., Skjødt, Mikkel-Ole, Kocsis, A., Zotter, Z., Gál, P., Varga, L., Farkas, H., Füst, G. & Garred, Peter, 2013, In: Molecular Immunology. 54, 3-4, p. 271-277 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2012
  46. Published

    Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis

    Pavlov, V. I., Skjødt, Mikkel-Ole, Siow Tan, Y., Rosbjerg, Anne, Garred, Peter & Stahl, G. L., 30 Oct 2012, In: Circulation. Supplement. 126, 18, p. 2227-35 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation

    Munthe-fog, L., Hummelshoj, T., Honoré, C., Moller, M. E., Skjødt, Mikkel-Ole, Palsgaard, I., Borregaard, N., Madsen, H. O. & Garred, Peter, 1 Oct 2012, In: Genes and Immunity. 13, 7, p. 515-522

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

    Skjødt, Mikkel-Ole, Roversi, P., Hummelshoj, T., Palarasah, Y., Rosbjerg, Anne, Johnson, S., Lea, S. M. & Garred, Peter, 21 Sep 2012, In: Journal of Biological Chemistry. 287, 39, p. 32913-32921

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The interaction pattern of murine serum ficolin-A with microorganisms

    Hummelshøj, T., Ma, Y. J., Munthe-Fog, L., Bjarnsholt, Thomas, Moser, Claus Ernst, Skjødt, Mikkel-Ole, Romani, L., Fujita, T., Endo, Y. & Garred, P., 2012, In: P L o S One. 7, 5, p. 1-12 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. 2011
  51. Published

    Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

    Füst, G., Munthe-Fog, L., Illes, Z., Széplaki, G., Molnar, T., Pusch, G., Hirschberg, K., Szegedi, R., Széplaki, Z., Prohászka, Z., Skjødt, Mikkel-Ole & Garred, Peter, 29 Dec 2011, In: Journal of Neuroinflammation. 8, p. 185

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Decreased material-activation of the complement system using low-energy plasma polymerized poly(vinyl pyrrolidone) coatings

    Andersen, T. E., Palarasah, Y., Skjødt, Mikkel-Ole, Ogaki, R., Benter, M., Alei, M., Kolmos, H. J., Koch, C. & Kingshott, P., Jul 2011, In: Biomaterials. 32, 20, p. 4481-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system

    Palarasah, Y., Nielsen, C., Sprogøe, U., Christensen, M. L., Lillevang, S., Madsen, H. O., Bygum, A., Koch, C., Skjodt, K. & Skjødt, Mikkel-Ole, Jun 2011, In: Clinical and Experimental Immunology. 164, 3, p. 388-95 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

    Ma, Y. J., Doni, A., Skjødt, Mikkel-Ole, Honore, C., Arendrup, Maiken Cavling, Mantovani, A. & Garred, Peter, 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3405-3417

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Serum concentration and interaction properties of MBL/ficolin associated protein-1

    Skjødt, Mikkel-Ole, Hummelshoj, T., Palarasah, Y., Hein, E., Munthe-fog, L., Koch, C., Skjodt, K. & Garred, Peter, 2011, In: Immunobiology. 216, 5, p. 625-632

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. 2010
  57. Published

    Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity

    Hansen, S., Selman, L., Palaniyar, N., Ziegler, K., Brandt, J., Kliem, A., Jonasson, M., Skjødt, Mikkel-Ole, Nielsen, O., Hartshorn, K., Jørgensen, Thomas, Skjødt, K. & Holmskov, U., 15 Nov 2010, In: Journal of immunology (Baltimore, Md. : 1950). 185, 10, p. 6096-104 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Functional analysis of Ficolin-3 mediated complement activation

    Hein, E., Honoré, C., Skjødt, Mikkel-Ole, Munthe-Fog, L., Hummelshøj, T. & Garred, Peter, 10 Nov 2010, In: PloS one. 5, 11, p. e15443

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

    Skjødt, Mikkel-Ole, Palarasah, Y., Munthe-fog, L., Jie Ma, Y., Weiss, G., Skjodt, K., Koch, C. & Garred, Peter, 1 Nov 2010, In: Immunobiology. 215, 11, p. 921-931

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3

    Palarasah, Y., Skjodt, K., Brandt, J., Teisner, B., Koch, C., Vitved, L. & Skjødt, Mikkel-Ole, 31 Oct 2010, In: Journal of Immunological Methods. 362, 1-2, p. 142-50 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

    Honore, C., Rorvig, S., Hummelshoj, T., Skjødt, Mikkel-Ole, Borregaard, N. & Garred, Peter, 1 Jul 2010, In: Journal of Leukocyte Biology. 88, 1, p. 145-158

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation

    Skjødt, Mikkel-Ole, Hummelshoj, T., Palarasah, Y., Honore, C., Koch, C., Skjodt, K. & Garred, Peter, 12 Mar 2010, In: Journal of Biological Chemistry. 285, 11, p. 8234-8243 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Sodium polyanethole sulfonate as an inhibitor of activation of complement function in blood culture systems

    Palarasah, Y., Skjødt, Mikkel-Ole, Vitved, L., Andersen, T. E., Skjoedt, K. & Koch, C., Mar 2010, In: Journal of Clinical Microbiology. 48, 3, p. 908-14 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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