Mads Gyrd-Hansen
Professor
Skin Immunology Research Center
Nørre Allé 14
2200 København N
- Published
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, Mads & Jost, P. J., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1796-1808Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M. & 10 others, , 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase
Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd-Hansen, Mads, Pilotte, L., Vigneron, N., De Plaen, E. & Van den Eynde, B. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 23, p. e2022447118Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Met1-linked ubiquitin machinery in inflammation and infection
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, 2021, In: Cell Death and Differentiation. 28, p. 557–569Research output: Contribution to journal › Review › Research › peer-review
The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation
Hrdinka, M. & Gyrd-Hansen, Mads, 19 Oct 2017, In: Molecular Cell. 68, 2, p. 265-280 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency
Dziadzio, M., Ammann, S., Canning, C., Boyle, F., Hassan, A., Cale, C., Elawad, M., Fiil, Berthe Katrine, Gyrd-Hansen, Mads, Salzer, U., Speckmann, C. & Grimbacher, B., 25 Jul 2015, In: Journal of Clinical Immunology. 35, 5, p. 439-444 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.
Gyrd-Hansen, Mads, Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, In: Journal of the Neurological Sciences. 197, 1-2, p. 27-35 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., Cuny, G. D., Huber, K. V., Filippakopoulos, P., Bullock, A. N., Degterev, A. & Gyrd-Hansen, Mads, 3 Sep 2018, In: The EMBO Journal. 37, 17Research output: Contribution to journal › Journal article › Research › peer-review
Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
Fehrenbacher, N., Gyrd-Hansen, Mads, Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, In: Cancer Research. 64, 15, p. 5301-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
Elliott, P. R., Leske, D., Hrdinka, M., Bagola, K., Fiil, Berthe Katrine, McLaughlin, S. H., Wagstaff, J., Volkmar, N., Christianson, J. C., Kessler, B. M., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 15 Sep 2016, In: Molecular Cell. 63, 6, p. 990-1005 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Elliott, P. R., Leske, D., Wagstaff, J., Schlicher, L., Berridge, G., Maslen, S., Timmermann, F., Ma, B., Fischer, R., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 2021, In: Cell Reports. 37, 1, 25 p., 109777.Research output: Contribution to journal › Journal article › Research › peer-review
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold
Suebsuwong, C., Dai, B., Pinkas, D. M., Duddupudi, A. L., Li, L., Bufton, J. C., Schlicher, L., Gyrd-Hansen, Mads, Hu, M., Bullock, A. N., Degterev, A. & Cuny, G. D., 2020, In: European Journal of Medicinal Chemistry. 200, 21 p., 112417.Research output: Contribution to journal › Journal article › Research › peer-review
RIPK2 NODs to XIAP and IBD
Topal, Y. & Gyrd-Hansen, Mads, 2021, In: Seminars in Cell and Developmental Biology. 109, p. 144-150 7 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
OTULIN deficiency causes auto-inflammatory syndrome
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Nov 2016, In: Cell Research. 26, 11, p. 1176-1177 2 p.Research output: Contribution to journal › Journal article › Commissioned
- Published
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin
Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, Berthe Katrine, Damgaard, R. B., Gyrd-Hansen, Mads & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis and regulation of OTULIN-LUBAC interaction
Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, Mads, Murphy, D. J., Huang, D. T., Zanivan, S. & Tait, S. W., 2024, In: The EMBO Journal. 43, 6, p. 904–930Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Met1-linked Ubiquitination in Immune Signalling
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Oct 2014, In: F E B S Journal. 81, 19, p. 4337-50 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Lysosomes and Nonapoptotic Pathways
Kirkegaard-Sørensen, T., Fehrenbacher, N., Gyrd-Hansen, Mads & Jüüttelü, M., 26 May 2008, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. John Wiley and Sons, Inc., Vol. 1. p. 599-622 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.
Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, Mads, Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling
Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, Mads, Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
Damgaard, R. B. & Gyrd-Hansen, Mads, 2011, In: Discovery Medicine. 11, 58, p. 221-31 11 p.Research output: Contribution to journal › Review › Research › peer-review
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors
Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, Mads, Degterev, A. & Bullock, A. N., 17 Sep 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4000197
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Molecular basis and regulation of OTULIN-LUBAC interaction
Research output: Contribution to journal › Journal article › Research › peer-review
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The Met1-linked ubiquitin machinery in inflammation and infection
Research output: Contribution to journal › Review › Research › peer-review
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Research output: Contribution to journal › Journal article › Research › peer-review
Published