Jens Bukh

Jens Bukh

Professor

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    ORCID: 0000-0002-7815-4806

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    1. Published

      Virus adaptation and selection following challenge of animals vaccinated against classical swine fever virus

      Fahnøe, Ulrik, Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2019, In: Viruses. 11, 10, 932.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

      Gottwein, Judith Margarete & Bukh, Jens, Sep 2013, In: Nature Reviews. Gastroenterology & Hepatology. 10, 9, p. 508-9 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

      STOP-HCV Consortium, S. C., 2021, In: Nature Communications. 12, 1, 11 p., 6105.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication

      Fahnøe, Ulrik, Pham, Long, Fernandez-Antunez, C., Costa, Rui, Rivera, Lizandro, Galli, Andrea, Feng, S., Mikkelsen, L. S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay & Bukh, Jens, 2022, In: Viruses. 14, 2, 172.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Vaccines against hepatitis C: A travel into neutralisation space

      Bukh, Jens, 2021, In: Gut. 70, 9, p. 1609-1610 2 p., 323377.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    6. Published

      Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

      Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers

      Prentø, Jannick, Janitzek, C. M., Velázquez-Moctezuma, R., Sørensen, Andreas Holst Holmegaard, Jørgensen, T., Clemmensen, S., Soroka, V., Thrane, Susan, Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Bukh, Jens & Sander, Adam F. , 2022, In: npj Vaccines. 7, 148.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution

      Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors

      Engle, R. E., Bukh, Jens, Alter, H. J., Emerson, S. U., Trenbeath, J. L., Nguyen, H. T., Brockington, A., Mitra, T. & Purcell, R. H., Nov 2014, In: Transfusion. 54, 11, p. 2833-41 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Toward a vaccine against hepatitis C virus

      Offersgaard, Anna Falden, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Science. 380, 6640, p. 37-38 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

      Bukh, Jens, Oct 2016, In: Journal of Hepatology. 65, 1 Suppl., p. S2-S21

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      The Role of CTLA-4 in T Cell Exhaustion in Chronic Hepatitis B Virus Infection

      Apol, Á. D., Winckelmann, Anni Assing, Duus, R. B., Bukh, Jens & Weis, Nina, 2023, In: Viruses. 15, 5, 1141.

      Research output: Contribution to journal › Review › Research › peer-review

    13. Published

      The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

      Stapleton, J. T., Foung, S., Muerhoff, A. S., Bukh, Jens & Simmonds, P., 2011, In: Journal of General Virology. 92, Pt 2, p. 233-46 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir

      Gammeltoft, Karen Anbro, Zhou, Y., Ryberg, Line Abildgaard, Pham, Long, Binderup, A., Duarte Hernandez, Carlos Rene, Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Viruses. 15, 9, 17 p., 1970.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

      Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential neutralization efficiency

      Czarnota, A., Offersgaard, A., Pihl, A. F., Prentø, Jannick, Bukh, Jens, Gottwein, Judith Margarete, Bieńkowska-Szewczyk, K. & Grzyb, K., 2020, In: Vaccines. 8, 2, 19 p., 294.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Sars-cov-2 production in a scalable high cell density bioreactor

      Offersgaard, Anna Falden, Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Pham, Long, Feng, S., Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      SARS-CoV-2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID-19 vaccination

      Castruita, J. A. S., Schneider, Uffe Vest, Mollerup, S., Leineweber, T. D., Weis, Nina, Bukh, Jens, Pedersen, M. S. & Westh, Henrik T., 2023, In: APMIS. 131, 3, p. 128-132 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses

      Christensen, D., Polacek, C., Sheward, D. J., Hanke, L., McInerney, G., Murrell, B., Hartmann, Katrine Top, Jensen, Henrik Elvang, Zimmermann, J., Jungersen, G., Illigen, K. E., Isling, L. K., Fernandez-Antunez, C., Ramirez Almeida, Santseharay, Bukh, Jens & Pedersen, Gabriel Kristian, 2023, In: Frontiers in Immunology. 14, 941281.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses

      Gottwein, J. M., Scheel, Troels Kasper Høyer, Hoegh, A. M., Lademann, J. B., Eugen-Olsen, J., Lisby, G. & Bukh, Jens, 2007, In: Gastroenterology. 133, 5, p. 1614-26 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

      Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

      Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

      Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Benfield, Thomas & Bukh, Jens, 2018, In: Journal of General Virology. 99, 8, p. 1066-1077 12 p., 001095.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

      Mejer, N., Galli, Andrea, Ramirez Almeida, Santseharay, Fahnøe, Ulrik, Benfield, Thomas & Bukh, Jens, 2020, In: Virology. 540, p. 132-140 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells

      Wolfisberg, R., Holmbeck, Kenn, Nielsen, L., Kapoor, A., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2019, In: Journal of Virology. 93, 19, 19 p., e00733-19.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae

      Postler, T. S., Beer, M., Blitvich, B. J., Bukh, Jens, de Lamballerie, X., Drexler, J. F., Imrie, A., Kapoor, A., Karganova, G. G., Lemey, P., Lohmann, V., Simmonds, P., Smith, D. B., Stapleton, J. T. & Kuhn, J. H., 2023, In: Archives of Virology. 168, 9, 224.

      Research output: Contribution to journal › Review › Research › peer-review

    27. Published

      Reflections on the History of HCV: A Posthumous Examination

      Alter, H. J., Farci, P., Bukh, Jens & Purcell, R. H., 2020, In: Clinical Liver Disease. 15, S1, p. S64-S71

      Research output: Contribution to journal › Review › Research › peer-review

    28. Published

      Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

      Humes, D., Ramirez Almeida, Santseharay, Jensen, T. B., Li, Y. P., Gottwein, Judith Margarete & Bukh, Jens, 2018, In: Virology. 522, p. 177-192 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a

      Scheel, Troels Kasper Høyer, Gottwein, J. M., Mikkelsen, L. S., Jensen, T. B. & Bukh, Jens, 2011, In: Gastroenterology Today. 140, 3, p. 1032-42 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy

      Christensen, D., Polacek, C., Sheward, D. J., Hanke, L., Moliner-morro, A., Mcinerney, G., Murrell, B., Hartmann, Katrine Top, Jensen, Henrik Elvang, Jungersen, G., Illigen, K., Isling, L. K., Jensen, R. F., Hansen, J. S., Rosenkrands, I., Fernandez-antunez, C., Ramirez Almeida, Santseharay, Follmann, F., Bukh, Jens & Pedersen, G. K., 2022, In: EBioMedicine. 84, 104248.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

      Smith, D. B., Becher, P., Bukh, Jens, Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In: Journal of General Virology. 97, p. 2894-2907 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

      Smith, D. B., Meyers, G., Bukh, Jens, Gould, E. A., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 2017, In: Journal of General Virology. 98, 8, p. 2106-2112 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

      Scheel, Troels Kasper Høyer, Galli, A., Li, Y., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

      Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain.

      Bukh, Jens, Thimme, R., Meunier, J., Faulk, K., Spangenberg, H. C., Chang, K., Satterfield, W., Chisari, F. V. & Purcell, R. H., 2008, In: Journal of Virology. 82, 16, p. 8183-95 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study

      Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A., Schlichting, P., Kromann-Andersen, H., Bukh, J., Weis, N., Hansen, N., Obel, N., Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A. & 4 others, Schlichting, P., Kromann-Andersen, H., Bukh, J. & Weis, Nina, 2009, In: Journal of Viral Hepatitis. 16, 9, p. 659-65 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Pre-existing, treatment-specific resistance-associated substitutions in hepatitis C virus genotype 1 and 3 and viral RNA titers during treatment with direct-acting antivirals

      Sølund, C., Pedersen, M. S., Fahnøe, Ulrik, Filskov, J., Jenssen, H., Weis, Nina, Schønning, Kristian & Bukh, Jens, 2023, In: APMIS. 131, 8, p. 426-433

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.

      Vanwolleghem, T., Bukh, Jens, Meuleman, P., Desombere, I., Meunier, J., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2008, In: Hepatology. 47, 6, p. 1846-1855 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?

      Bukh, Jens, Lanford, R. E. & Purcell, R. H., Nov 2013, In: Hepatology. 58, 5, p. 1533-6 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection

      Tomlinson, J. E., Wolfisberg, R., Fahnøe, Ulrik, Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, Jens, Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2021, In: Hepatology. 74, 3, p. 1148-1163

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication

      Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Galli, Andrea, Underwood, Alexander Paul James, Pham, Long, Ryberg, Line Abildgaard, Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, Nina, Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

      Sølund, C., cgl303, cgl303, Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, Jan, Christensen, P. B., Pedersen, M. S., Schønning, Kristian, Fahnøe, Ulrik, Bukh, Jens & Weis, Nina, 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

      Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, Jens, 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment

      Winckelmann, Anni Assing, Fahnøe, Ulrik, Bajpai, P. S., Dalegaard, M. I., Lundh, A., Ryom, L., Bukh, Jens & Weis, Nina, 2022, In: Journal of Clinical Virology. 150-151, 6 p., 105159.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization

      Pham, Long, Velázquez-Moctezuma, R., Fahnøe, Ulrik, Collignon, Laura Maria F, Bajpai, P., Sølund, C., Weis, Nina, Holmbeck, Kenn, Prentø, Jannick & Bukh, Jens, 2022, In: Viruses. 14, 11, 2527.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

      Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

      Zhou, Y., Gammeltoft, Karen Anbro, Ryberg, Line Abildgaard, Pham, Long, Tjørnelund, H. D., Binderup, A., Duarte Hernandez, Carlos Rene, Fernandez-Antunez, C., Offersgaard, Anna Falden, Fahnøe, Ulrik, Peters, G. H. J., Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Science Advances. 8, 51, eadd7197.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

      Sabo, M. C., Luca, V. C., Prentø, Jannick, Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, Jens, Evans, M. J., Fremont, D. H. & Diamond, M. S., 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Neutralizing antibody and CD8+ T cell responses following BA.4/5 bivalent COVID-19 booster vaccination in adults with and without prior exposure to SARS-CoV-2

      Underwood, Alexander Paul James, Sølund, C., Jacobsen, K., Binderup, A., Fernandez-Antunez, C., Mikkelsen, L. S., Inekci, D., Villadsen, S. L., Castruita, J. A. S., Pinholt, M., Fahnøe, Ulrik, Ramirez, S., Brix, L., Weis, Nina & Bukh, Jens, 2024, In: Frontiers in Immunology. 15, 14 p., 1353353.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

      Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses

      Pedersen, J., Jensen, T. B., Carlsen, T. H. R., Schønning, Kristian, Christensen, P. B., Laursen, A. L., Krarup, H., Bukh, Jens & Weis, Nina, 2013, In: P L o S One. 8, 5, 16 p., e62674.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection

      Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, Jens & Weis, Nina, Oct 2016, In: Journal of Medical Virology. 88, 10, p. 1791-1803 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Neutralizing Antibodies Against Hepatitis C Virus and Their Role in Vaccine Immunity

      Bukh, Jens, 2022, In: Gastroenterology. 162, 2, p. 396-398 3 p.

      Research output: Contribution to journal › Editorial › Research › peer-review

    54. Published

      Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

      Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV

      Wolfisberg, R., Thorselius, Caroline Eva, Salinas, E., Elrod, E., Trivedi, S., Nielsen, L., Fahnøe, Ulrik, Kapoor, A., Grakoui, A., Rice, C. M., Bukh, Jens, Holmbeck, Kenn & Scheel, Troels Kasper Høyer, 2022, In: Hepatology. 76, 5, p. 1506-1519

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19

      Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Winckelmann, A. A., Bollerup, S., Mikkelsen, L. S., Sørensen, A. L., Feng, S., Fahnøe, Ulrik, Lassauniere, R., Fomsgaard, A., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2021, In: EBioMedicine. 71, 103519.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C

      Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: identification of viral resistance mutations

      Sølund, C., Krarup, H., Ramirez Almeida, Santseharay, Thielsen, P., Røge, B. T., Lunding, S., Barfod, Toke Seierøe, Madsen, Lone Galmstrup, Tarp, B., Christensen, P. B., Gerstoft, Jan, Laursen, A. L., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2014, In: PLOS ONE. 9, 12, p. 1-20 20 p., e113034.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

      Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Weiland, O., Benfield, Thomas & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles

      Russell, R. S., Kawaguchi, K., Meunier, J., Takikawa, S., Faulk, K., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 2009, In: Journal of Viral Hepatitis. 16, 9, p. 621-32 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Mouse models of acute and chronic hepacivirus infection

      Billerbeck, E., Wolfisberg, R., Fahnøe, Ulrik, Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, Jens, Scheel, Troels Kasper Høyer, Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Monitoring of hepatitis C virus quasispecies in chronic infection by matrix-assisted laser desorption ionization-time of flight mass spectrometry mutation detection

      Yea, C., Bukh, Jens, Ayers, M., Roberts, E., Krajden, M. & Tellier, R., 2007, In: Journal of Clinical Microbiology. 45, 3, p. 1053-1057 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins

      Takikawa, S., Engle, R. E., Faulk, K. N., Emerson, S. U., Purcell, R. H. & Bukh, Jens, 2010, In: Journal of General Virology. 91, Pt 3, p. 727-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Molecular and epidemiological profiles of hepatitis C virus genotype 4 in Denmark

      Eriksen, M. B., Jørgensen, L. B., Krarup, H., Laursen, A. L., Christensen, P. B., Møller, A., Schlichting, P., Kuiken, C., Bukh, Jens, Weis, N. & DANHEP Group, D. G., 2010, In: Journal of Medical Virology. 82, 11, p. 1869-1877 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Molecular Determinants of Mouse Adaptation of Rat Hepacivirus

      Wolfisberg, R., Holmbeck, Kenn, Billerbeck, E., Thorselius, Caroline Eva, Batista, M. N., Fahnøe, Ulrik, Lundsgaard, Emma Alberte, Kennedy, Matthew James, Nielsen, L., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Journal of Virology. 97, 4, 17 p., e0181222.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

      Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Mechanisms and Consequences of Genetic Variation in Hepatitis C Virus (HCV)

      Galli, Andrea & Bukh, Jens, 2023, Viral Fitness and Evolution: Population Dynamics and Adaptive Mechanisms. Springer, p. 237-264 28 p. (Current Topics in Microbiology and Immunology, Vol. 439).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    68. Published

      MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

      Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1-3 Strains and Does Not Correlate with Virus Replication

      Galli, Andrea, Ramirez Almeida, Santseharay & Bukh, Jens, 2021, In: Viruses. 13, 3, 389.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus

      Meunier, J., Russell, R. S., Goossens, V., Priem, S., Walther, H., Depla, E., Union, A., Faulk, K. N., Bukh, Jens, Emerson, S. U. & Purcell, R. E., 2008, In: Journal of Virology. 82, 2, p. 966-73 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Published

      Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

      Mateu, G., Donis, R. O., Wakita, T., Bukh, Jens & Grakoui, A., 2008, In: Virology. 376, 2, p. 397-407 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Published

      Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

      Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon

      Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez Almeida, Santseharay, Bukh, Jens & Harris, M., 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Published

      Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

      Madsen, L. W., Christensen, P. B., Fahnøe, Ulrik, Pedersen, M. S., Bukh, Jens & Øvrehus, A., 2021, In: Liver International. 41, 11, p. 2601-2610

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Published

      Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398

      Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236

      Research output: Patent

    76. Published

      Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

      Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197

      Research output: Patent

    77. Published

      Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice

      Pihl, A. F., Feng, S., Offersgaard, Anna Falden, Alzua, G. P., Augestad, Elias Honerød, Mathiesen, C. K., Jensen, T. B., Krarup, H., Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2022, In: Journal of Hepatology. 76, 5, p. 1051-1061

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Published

      Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice

      Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Duarte Hernandez, Carlos Rene, Duan, Z., Feng, S., Fahnøe, Ulrik, Sølund, C., Weis, Nina, Law, M., Prentø, Jannick, Christensen, Jan Pravsgaard, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Gut. 72, 3, p. 560-572

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells

      Sakai, A., Takikawa, S., Thimme, R., Meunier, J. C., Spangenberg, H. C., Govindarajan, S., Farci, P., Emerson, S. U., Chisari, F. V., Purcell, R. H. & Bukh, Jens, 2007, In: Journal of Virology. 81, 13, p. 7208-7219 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Published

      In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

      Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62

      Research output: Contribution to journal › Journal article › Research › peer-review

    81. Published

      In vitro neutralization assay using cultured hepatitis C virus

      Prentø, Jannick & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    82. Published

      In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

      Zhou, Y., Gilmore, K., Ramirez Almeida, Santseharay, Settels, E., Gammeltoft, Karen Anbro, Pham, Long, Fahnøe, Ulrik, Feng, S., Offersgaard, Anna Falden, Trimpert, J., Bukh, Jens, Osterrieder, K., Gottwein, Judith Margarete & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.

      Research output: Contribution to journal › Journal article › Research › peer-review

    83. Published

      Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

      Bukh, Jens, Engle, R. E., Faulk, K., Wang, R. Y., Farci, P., Alter, H. J. & Purcell, R. H., Sep 2015, In: Journal of Virology. 89, 17, p. 9128-9132 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Published

      Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived

      Bukh, Jens, Engle, R. E., Govindarajan, S. & Purcell, R. H., 2008, In: Journal of Medical Virology. 80, 1, p. 87-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    85. Published

      Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection

      Fossat, Nicolas Julien, Lundsgaard, Emma Alberte, Costa, Rui, Rivera, Lizandro, Nielsen, L., Mikkelsen, L. S., Ramirez Almeida, Santseharay, Bukh, Jens & Scheel, Troels Kasper Høyer, 2023, In: Cell Reports. 42, 4, 112282.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

      Fahnøe, Ulrik, Deng, Y., Davids, N. A., Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Published

      Identification of novel neutralizing determinants for protection against HCV

      Alzua, G. P., Pihl, A. F., Offersgaard, Anna Falden, Velázquez-Moctezuma, R., Duarte Hernandez, Carlos Rene, Augestad, Elias Honerød, Fahnøe, Ulrik, Mathiesen, C. K., Krarup, H., Law, M., Prentø, Jannick, Bukh, Jens & Gottwein, Judith Margarete, 2023, In: Hepatology. 73, 3, p. 982-996

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

      Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Published

      Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

      Riva, L., Song, O., Prentø, Jannick, Helle, F., L'homme, L., Gattolliat, C., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, Jens, Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

      Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Published

      Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

      Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Published

      Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

      Prentø, Jannick, Velázquez-Moctezuma, R., Augestad, E. H., Galli, Andrea, Wang, R., Law, M., Alter, H. & Bukh, Jens, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. Published

      Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

      Prentø, Jannick & Bukh, Jens, 2018, In: Frontiers in Immunology. 9, 11 p., 2146.

      Research output: Contribution to journal › Review › Research › peer-review

    94. Published

      Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity

      Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

      Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Published

      Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

      Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    97. Published

      Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

      Brown, A. J., Won, J. J., Wolfisberg, R., Fahnøe, U., Catanzaro, N., West, A., Moreira, F. R., Nogueira Batista, M., Ferris, M. T., Linnertz, C. L., Leist, S. R., Nguyen, C., De La Cruz, G., Midkiff, B. R., Xia, Y., Evangelista, M. D., Montgomery, S. A., Billerbeck, E., Bukh, J., Scheel, T. K. H. & 2 others, Rice, C. M. & Sheahan, T. P., 2024, In: Hepatology. 79, 1, p. 183-197

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Published

      High‐Titer Hepatitis C Virus Production in a Scalable Single‐Use High Cell Density Bioreactor

      Offersgaard, Anna Falden, Duarte Hernandez, C. R., Finne Pihl, A., Prabhakar Venkatesan, N., Krarup, H., Lin, X., Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2022, In: Vaccines. 10, 2, 249.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Published

      Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

      Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Published

      Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

      Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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