Hans K Hasselbalch

Hans K Hasselbalch

Clinical Professor

Member of:

  • Internal Medicine: Haematology


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  1. Published

    Non-invasive imaging of retinal blood flow in myeloproliferative neoplasms

    Willerslev, A., Hansen, M. M., Klefter, O. N., Bjerrum, O. W., Hasselbalch, Hans Carl, Clemmensen, S. N., Larsen, Michael & Munch, I. C., Mar 2017, In: Acta Ophthalmologica. 95, 2, p. 146–152

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Whole Blood Gene Expression Profiling in patients undergoing colon cancer surgery identifies differential expression of genes involved in immune surveillance, inflammation and carcinogenesis

    Watt, S. K., Hasselbalch, Hans Carl, Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M. & Gögenur, Ismail, 2018, In: Surgical Oncology. 27, 2, p. 208-215 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Increased oxidative stress with substantial dysregulation of genes related to oxidative stress and DNA repair after laparoscopic colon cancer surgery

    Watt, S. K., Hasselbalch, Hans Carl, Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M., Poulsen, Henrik Enghusen & Gögenur, Ismail, 2020, In: Surgical Oncology. 35, p. 71-78 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Elevated white blood cell counts in ischemic stroke patients are associated with increased mortality and new vascular events

    Vo, T. P., Kristiansen, M. H., Hasselbalch, Hans Carl & Wienecke, Troels, 2023, In: Frontiers in Neurology. 14, 8 p., 1232557.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms

    Tolstrup Larsen, R., Tang, L. H., Brochmann, N., Meulengracht Flachs, E., Illemann Christensen, A., Hasselbalch, Hans Carl & Zwisler, A., 2018, In: European Journal of Haematology. 100, 6, p. 550-559 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Smoking impairs molecular response, and reduces overall survival in patients with chronic myeloproliferative neoplasms: A retrospective cohort study

    Sørensen, A. L., Knudsen, T. A., Skov, V., Kjær, L., Holm, N., Ellervik, Christina & Hasselbalch, Hans Carl, 2021, In: British Journal of Haematology. 193, 1, p. 83-92

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Antecedent cardiovascular disease and autoimmunity in Philadelphia-negative chronic myeloproliferative neoplasms

    Sørensen, A. L. & Hasselbalch, Hans Carl, 1 Feb 2016, In: Leukemia Research. 41, p. 27-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study

    Sørensen, A. L., Hasselbalch, Hans Carl, Bjørn, M. E., Nielsen, C. H., Cordua, S., Skov, V., Kjær, L., Poulsen, Henrik Enghusen & Ellervik, Christina, 2021, In: Redox Biology. 41, 101895.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Statin treatment, oxidative stress and inflammation in a Danish population

    Sørensen, A. L., Hasselbalch, Hans Carl, Nielsen, C. H., Poulsen, Henrik Enghusen & Ellervik, C., 2019, In: Redox Biology. 21, 7 p., 101088.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

    Solli, C. N., Chamat-Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, Christina, Fuchs, A., Sigvardsen, P. E., Kühl, J. T., Kofoed, Klaus Fuglsang, Nordestgaard, Børge, Hasselbalch, Hans Carl & Bruun, Niels Eske, 2022, In: International Journal of Cardiology. 364, p. 112-118 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    High JAK2V617F variant allele frequency is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

    Solli, C. N., Chamat-Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, Christina, Hasselbalch, Hans Carl & Bruun, Niels Eske, 2023, In: European Journal of Haematology. 111, 3, p. 400-406 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms

    Skov, V., Thomassen, M., Kjær, L., Ellervik, Christina, Larsen, Morten Kranker, Knudsen, T. A., Kruse, T. A. & Hasselbalch, Hans Carl, 2022, In: PLoS ONE. 17, 6 , e0270669.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance

    Skov, V., Thomassen, M., Kruse, T. A., Larsen, T. S., Riley, C. H., Jensen, M. S. K., Bjerrum, O. W. & Hasselbalch, Hans Carl, 1 Nov 2012, In: Leukemia Research. 36, 11, p. 1387-1392 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis

    Skov, V., Thomassen, M., Kruse, T. A., Riley, C. H., Jensen, M. K., Bjerrum, O. W., Hasselbalch, Hans Carl & Larsen, T. S., 1 Sep 2012, In: Experimental Hematology. 40, 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis

    Silver, R. T., Kiladjian, J. & Hasselbalch, Hans Carl, Feb 2013, In: Expert Review of Hematology. 6, 1, p. 49-58 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Optimal therapy for polycythemia vera and essential thrombocythemia: Preferred use of interferon therapy based on phase 2 trials

    Silver, R. T. & Hasselbalch, Hans Carl, 2016, In: Hematology. 21, 7, p. 387-391 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

    Hasselbalch, Hans Carl, Skov, V., Larsen, T. S., Thomassen, M., Riley, C. H., Jensen, M. K., Bjerrum, O. W. & Kruse, T. A., 2011, In: Leukemia Research. 35, 10, p. 1330-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera

    Riley, C. H., Brimnes, M. K., Hansen, M., Jensen, M. K., Hasselbalch, Hans Carl, Kjaer, L., Straten, P. T. & Svane, Inge Marie, 2016, In: European Journal of Haematology. 97, 1, p. 83-92 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Increase in circulating CD4CD25Foxp3 T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α

    Riley, C. H., Morten Krogh, J., Brimnes, M. K., Straten, P. T., Svane, Inge Marie, Hasselbalch, Hans Carl & Bjerrum, O. W., 25 Aug 2011, In: Blood. 118, 8, p. 2170-2173 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms

    Pedersen, R. K., Andersen, M., Knudsen, T. A., Sajid, Z., Gudmand-Hoeyer, J., Dam, M. J. B., Skov, V., Kjær, L., Ellervik, Christina, Larsen, T. S., Hansen, D., Pallisgaard, N., Hasselbalch, Hans Carl & Ottesen, J. T., 2020, In: Cancer Medicine. 9, 6, p. 2039-2051

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms: An explorative study

    Pedersen, K. M., Zangger, G., Brochmann, N., Grønfeldt, B. M., Zwisler, A. D., Hasselbalch, Hans Carl & Tang, L. H., 2018, In: European Journal of Cancer Care. 27, 5, 10 p., e12865.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

    Pedersen, K. M., Çolak, Y., Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2020, In: EClinicalMedicine. 21, 100280.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Smoking and Increased White and Red Blood Cells

    Pedersen, K. M., Çolak, Y., Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2019, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 5, p. 965-977 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm

    Pedersen, K. M., Çolak, Y., Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2020, In: EClinicalMedicine. 22, 100337.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  25. Published

    Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study

    Pedersen, K. M., Çolak, Y., Hasselbalch, Hans Carl, Ellervik, Christina, Nordestgaard, Børge & Bojesen, Stig Egil, 2020, In: EClinicalMedicine. 21, 100295.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study

    Pedersen, K. M., Bak, M., Sørensen, A. L., Zwisler, A., Ellervik, Christina, Larsen, M. K., Hasselbalch, Hans Carl & Tolstrup, J. S., 2018, In: Cancer Medicine. 7, 11, p. 5796-5802 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Age-related prevalence and clinical significance of neutropenia - isolated or combined with other cytopenias: Real world data from 373 820 primary care individuals

    Palmblad, J., Siersma, Volkert Dirk, Lind, B., Bjerrum, O. W., Hasselbalch, Hans Carl & Andersen, Christen Bertel L, 2020, In: American Journal of Hematology. 95, 5, p. 521-528 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Bridging blood cancers and inflammation: The reduced Cancitis model

    Ottesen, J. T., Pedersen, R. K., Sajid, Z., Gudmand-hoeyer, J., Bangsgaard, K. O., Skov, V., Kjær, L., Knudsen, T. A., Pallisgaard, N., Hasselbalch, Hans Carl & Andersen, M., 2019, In: Journal of Theoretical Biology. 465, p. 90-108

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

    Myrtue Nielsen, H., Andersen, Christen Bertel L, Westman, M., Sommer Kristensen, L., Asmar, F., Arvid Kruse, T., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Hasselbalch, Hans Carl, Punj, V. & Grønbæk, Kirsten, 2017, In: Scientific Reports. 7, 11 p., 6774.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

    Mikkelsen, Stine Ulrik, Kjaer, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, Christen Bertel L, Bjerrum, O. W., Brochmann, N., Fassi, Daniel El , Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, Claus Henrik, Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, Hans Carl, Aug 2018, In: Cancer Medicine. 7, 8, p. 3571-3581 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Methylation age as a correlate for allele burden, disease status, and clinical response in myeloproliferative neoplasm patients treated with vorinostat

    McPherson, S., Greenfield, G., Andersen, Christen Bertel L, Grinfeld, J., Hasselbalch, Hans Carl, Nangalia, J., Mills, K. I. & McMullin, M. F., 2019, In: Experimental Hematology. 79, p. 26-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Interferon alpha-2 treatment reduces circulating neutrophil extracellular trap levels in myeloproliferative neoplasms

    Massarenti, Laura, Knudsen, T. A., Enevold, Christian, Skov, V., Kjær, L., Larsen, M. K., Larsen, T. S., Hansen, D. L., Hasselbalch, Hans Carl & Nielsen, Claus Henrik, 2023, In: British Journal of Haematology. 202, 2, p. 318-327 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience

    Madelung, A. B., Bondo, H., Stamp, I., Løvgreen, P., Nielsen, S. L., Falensteen, A., Knudsen, H., Svendsen, K. D., Lange, Theis, Ralfkiaer, E., Nielsen, K., Hasselbalch, Hans Carl & Thiele, J., Sep 2015, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 123, 9, p. 787-92 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    A novel immunohistochemical sequential multi-labelling and erasing technique enables epitope characterization of bone marrow pericytes in primary myelofibrosis

    Madelung, A., Bzorek, M., Bondo, H., Zetterberg, E., Bjerrum, O. W., Hasselbalch, Hans Carl, Scheding, S. & Ralfkiaer, E., 2012, In: Histopathology. 60: 554 – 660.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms

    Liisborg, C., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2020, In: Cancers. 12, 3, 14 p., 573.

    Research output: Contribution to journal › Review › Research › peer-review

  36. Published

    Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation

    Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2022, In: EClinicalMedicine. 43, 101248.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers

    Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, Jun 2022, In: PLoS ONE. 17, 6, 16 p., e0269960.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Retinal drusen in patients with chronic myeloproliferative blood cancers are associated with an increased proportion of senescent T cells and signs of an aging immune system

    Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2021, In: Aging. 13, 24, p. 25763—25777

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Patients with myeloproliferative neoplasms and high levels of systemic inflammation develop age-related macular degeneration

    Liisborg, C., Krogh Nielsen, M., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2020, In: EClinicalMedicine. 26, 8 p., 100526.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence

    Lataillade, J. J., Pierre-Louis, O., Uzan, G., Jasmin, C., Martyre, M. C., Bousse-Kerdiles, M. C. L. & Hasselbalch, Hans Carl, 2008, In: Blood. 112, 8, p. 3026-3035 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms-a Danish longitudinal study

    Larsen, Morten Kranker, Skov, V., Kjær, L., Eickhardt-Dalbøge, C. S., Knudsen, T. A., Kristiansen, M. H., Sørensen, A. L., Wienecke, Troels, Andersen, M., Ottesen, J. T., Gudmand-Høyer, J., Snyder, J. A., Andersen, M. P., Torp-Pedersen, Christian, Poulsen, Henrik Enghusen, Stiehl, T., Hasselbalch, Hans Carl & Ellervik, Christina, 2024, In: Blood Cancer Journal. 14, 1, 12 p., 28.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up

    Larsen, Morten Kranker, Skov, V., Kjær, L., Møller-Palacino, N. A., Pedersen, R. K., Andersen, M., Ottesen, J. T., Cordua, S., Poulsen, Henrik Enghusen, Dahl, Morten, Knudsen, T. A., Eickhardt-Dalbøge, C. S., Koschmieder, S., Pedersen, K. M., Çolak, Y., Bojesen, Stig Egil, Nordestgaard, Børge, Stiehl, T., Hasselbalch, Hans Carl & Ellervik, Christina, 2022, In: European Journal of Haematology. 109, 5, p. 576-585 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study

    Kristiansen, M. H., Kjær, L., Skov, V., Larsen, Morten Kranker, Ellervik, Christina, Hasselbalch, Hans Carl & Wienecke, Troels, 2023, In: Blood advances. 7, 19, p. 5825-5834 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Genomic profiling of a randomized trial of interferon-a vs hydroxyurea in MPN reveals mutation-specific responses

    Knudsen, T. A., Skov, V., Stevenson, K., Werner, L., Duke, W., Laurore, C., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Hansen, D. L., Ellervik, C., Fassi, D. E., de Stricker, K., Ocias, L. F., Brabrand, M., Bjerrum, O. W., Overgaard, U. M., Frederiksen, M., Kristensen, T. K. & 12 others, Kruse, T. A., Thomassen, M., Mourits-Andersen, T., Severinsen, M. T., Stentoft, J., Starklint, J., Neuberg, D. S., Kjaer, L., Larsen, T. S., Hasselbalch, Hans Carl, Lindsley, R. C. & Mullally, A., 2022, In: Blood advances. 6, 7, p. 2107-2119 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis

    Kjær, L., Skov, V., Larsen, Morten Kranker, Boklund, T. I., Andersen, M., Kefala, Maria, Knudsen, T. A., Schjellerup Eickhardt-Dalbøge, C., Stiehl, T., Gudmand-Høyer, J., Snyder, J., Holmström, M., Andersen, M. H., Ottesen, J. T., Ellervik, Christina & Hasselbalch, Hans Carl, 2023, In: Frontiers in Oncology. 13, 8 p., 1176173.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    A highly sensitive quantitative real-time pcr assay for determination of mutant jak2 exon 12 allele burden

    Kjær, L., Riley, C. H., Westman, M., Høgdall, Estrid Vilma Solyom, Bjerrum, O. W. & Hasselbalch, Hans Carl, 5 Mar 2012, In: PLOS ONE. 7, 3

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

    Kjaer, L., Holmström, M. O., Cordua, S., Andersen, Mads Hald, Svane, Inge Marie, Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, Hans Carl, Apr 2018, In: Leukemia and Lymphoma. 59, 4, p. 973-977 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Variant‐specific discrepancy when quantitating BCR‐ABL1 e13a2 and e14a2 transcripts using the Europe Against Cancer qPCR assay

    Kjaer, L., Skov, V., Andersen, M. T., Aggerholm, A., Clair, P., Gniot, M., Søby, K., Udby, L., Dorff, Mikkel Helleberg, Hasselbalch, Hans Carl & Pallisgaard, N., 2019, In: European Journal of Haematology. 103, 1, p. 26-34

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Long-term outcomes of polycythemia vera patients treated with ropeginterferon Alfa-2b

    PROUD-PV Study Grp, P. S. G., May 2022, In: Leukemia. 36, 5, p. 1408-1411 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  50. Published

    Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation

    Jørgensen, M. A., Holmström, M. O., Martinenaite, E., Riley, C. H., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2018, In: OncoImmunology. 7, 9, 8 p., e1468957.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 2849472