Jens Bukh

Jens Bukh

Professor

Member of:


    1. 2013
    2. Published

      Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

      Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. 2012
    4. Published

      Animal models for the study of hepatitis C virus infection and related liver disease

      Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C

      Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

      Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

      Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

      Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

      Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

      Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

      Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

      Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. 2011
    14. Published

      FLAVIVIRDAE

      Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    15. Published

      Hepatitis C homolog in dogs with respiratory illness

      Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution

      Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

      Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort

      Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

      Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

      Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

      Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

      Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

      Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

      Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

      Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

      Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

      Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published
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