Jens Bukh
Professor
Virology
Blegdamsvej 3B, 2200 København N, 07 Bygning 7, Building: 07-13-84
Member of:
- 2013
- Published
Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance
Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Animal models for the study of hepatitis C virus infection and related liver disease
Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C
Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate
Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system
Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature
Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells
Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
FLAVIVIRDAE
Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Hepatitis C homolog in dogs with respiratory illness
Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution
Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort
Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort
Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study
Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon
Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR
Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively
Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus
Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain
Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C virus expressing flag-tagged envelope protein 2 has unaltered infectivity and density, is specifically neutralized by flag antibodies and can be purified by affinity chromatography
Prentø, Jannick & Bukh, Jens, 2011, In: Virology. 409, 2, p. 148-55Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12437
Most downloads
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418
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Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Research output: Contribution to journal › Review › Research › peer-review
Published -
385
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
347
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Research output: Contribution to journal › Review › Research › peer-review
Published