Mads Gyrd-Hansen
Professor
Skin Immunology Research Center
Nørre Allé 14
2200 København N
- Published
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 others, , 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.Research output: Contribution to journal › Journal article › Research › peer-review
A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency
Ammann, S., Elling, R., Gyrd-Hansen, Mads, Dückers, G., Bredius, R., Burns, S. O., Edgar, J. D. M., Worth, A., Brandau, H., Warnatz, K., zur Stadt, U., Hasselblatt, P., Schwarz, K., Ehl, S. & Speckmann, C., 2014, In: Clinical and Experimental Immunology. 176, 3, p. 394-400 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
All roads lead to ubiquitin
Gyrd-Hansen, Mads, 2017, In: Cell Death and Differentiation. 24, 7, p. 1135-1136 2 p.Research output: Contribution to journal › Editorial › Research
- Published
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9
Gyrd-Hansen, Mads, Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jaattela, Marja, 2006, In: Molecular and Cellular Biology. 26, 21, p. 7880-7891Research output: Contribution to journal › Journal article › Research › peer-review
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
Prabakaran, T., Bodda, C., Krapp, C., Zhang, B-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R., Gyrd-Hansen, M. & 1 others, , 13 Apr 2018, In: The EMBO Journal. 37, 8, e97858.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death
Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
Hrdinka, M., Fiil, Berthe Katrine, Zucca, M., Leske, D., Bagola, K., Yabal, M., Elliott, P. R., Damgaard, R. B., Komander, D., Jost, P. J. & Gyrd-Hansen, Mads, 29 Mar 2016, In: Cell Reports. 14, 12, p. 2846-58 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cell scientist to watch - Mads Gyrd-Hansen
Gyrd-Hansen, Mads, 2017, In: Journal of Cell Science. 130, 12, p. 1981-1983 3 p.Research output: Contribution to journal › Comment/debate › Research
Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling
Nikhar, S., Siokas, I., Schlicher, L., Lee, S., Gyrd-Hansen, Mads, Degterev, A. & Cuny, G. D., 2021, In: European Journal of Medicinal Chemistry. 215, 113252.Research output: Contribution to journal › Journal article › Research › peer-review
Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.
Lademann, U., Cain, K., Gyrd-Hansen, Mads, Brown, D., Peters, D. & Jäättelä, M., 2003, In: Molecular and Cellular Biology. 23, 21, p. 7829-37 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection
Bodda, C., Reinert, L. S., Fruhwürth, S., Richardo, T., Sun, C., Zhang, B., Kalamvoki, M., Pohlmann, A., Mogensen, T. H., Bergström, P., Agholme, L., O'Hare, P., Sodeik, B., Gyrd-Hansen, Mads, Zetterberg, H. & Paludan, S. R., 2020, In: The Journal of Experimental Medicine. 217, 7Research output: Contribution to journal › Journal article › Research › peer-review
Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.
Krag, T. O., Gyrd-Hansen, Mads & Khurana, T. S., 2001, In: Acta Physiologica (Print Edition). 171, 3, p. 349-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
Gyrd-Hansen, Mads, Nylandsted, J. & Jäättelä, M., 2004, In: Cell Cycle. 3, 12, p. 1484-5 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
Nylandsted, J., Gyrd-Hansen, Mads, Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, In: Journal of Experimental Medicine. 200, 4, p. 425-435 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heregulin-induced epigenetic regulation of the utrophin-A promoter.
Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1
Peng, R., Wang, Chris Kedong, Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, Berthe Katrine, Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, Mads, 2022, In: EMBO Reports. 2022, 23, e55839.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis
Gyrd-Hansen, Mads, Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, In: Nature Cell Biology. 10, 11, p. 1309-17 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer
Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews Cancer.Research output: Contribution to journal › Journal article › Commissioned › peer-review
- Published
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews. Cancer. 10, 8, p. 561-74 13 p.Research output: Contribution to journal › Review › Research › peer-review
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease
Schwerd, T., Pandey, S., Yang, H-T., Bagola, K., Jameson, E., Jung, J., Lachmann, R. H., Shah, N., Patel, S. Y., Booth, C., Runz, H., Düker, G., Bettels, R., Rohrbach, M., Kugathasan, S., Chapel, H., Keshav, S., Elkadri, A., Platt, N., Muise, A. M. & 8 others, , Jun 2017, In: Gut. 66, 6, p. 1060-1073 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors
Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, Mads, Degterev, A. & Bullock, A. N., 17 Sep 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
Damgaard, R. B. & Gyrd-Hansen, Mads, 2011, In: Discovery Medicine. 11, 58, p. 221-31 11 p.Research output: Contribution to journal › Review › Research › peer-review
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling
Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, Mads, Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9Research output: Contribution to journal › Journal article › Research › peer-review
JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.
Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, Mads, Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-13 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysosomes and Nonapoptotic Pathways
Kirkegaard-Sørensen, T., Fehrenbacher, N., Gyrd-Hansen, Mads & Jüüttelü, M., 26 May 2008, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. John Wiley and Sons, Inc., Vol. 1. p. 599-622 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Met1-linked Ubiquitination in Immune Signalling
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Oct 2014, In: F E B S Journal. 81, 19, p. 4337-50 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response
Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, Mads, Murphy, D. J., Huang, D. T., Zanivan, S. & Tait, S. W., 2024, In: The EMBO Journal. 43, 6, p. 904–930Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis and regulation of OTULIN-LUBAC interaction
Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin
Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, Berthe Katrine, Damgaard, R. B., Gyrd-Hansen, Mads & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
OTULIN deficiency causes auto-inflammatory syndrome
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Nov 2016, In: Cell Research. 26, 11, p. 1176-1177 2 p.Research output: Contribution to journal › Journal article › Commissioned
RIPK2 NODs to XIAP and IBD
Topal, Y. & Gyrd-Hansen, Mads, 2021, In: Seminars in Cell and Developmental Biology. 109, p. 144-150 7 p.Research output: Contribution to journal › Review › Research › peer-review
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold
Suebsuwong, C., Dai, B., Pinkas, D. M., Duddupudi, A. L., Li, L., Bufton, J. C., Schlicher, L., Gyrd-Hansen, Mads, Hu, M., Bullock, A. N., Degterev, A. & Cuny, G. D., 2020, In: European Journal of Medicinal Chemistry. 200, 21 p., 112417.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Elliott, P. R., Leske, D., Wagstaff, J., Schlicher, L., Berridge, G., Maslen, S., Timmermann, F., Ma, B., Fischer, R., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 2021, In: Cell Reports. 37, 1, 25 p., 109777.Research output: Contribution to journal › Journal article › Research › peer-review
SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
Elliott, P. R., Leske, D., Hrdinka, M., Bagola, K., Fiil, Berthe Katrine, McLaughlin, S. H., Wagstaff, J., Volkmar, N., Christianson, J. C., Kessler, B. M., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 15 Sep 2016, In: Molecular Cell. 63, 6, p. 990-1005 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
Fehrenbacher, N., Gyrd-Hansen, Mads, Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, In: Cancer Research. 64, 15, p. 5301-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., Cuny, G. D., Huber, K. V., Filippakopoulos, P., Bullock, A. N., Degterev, A. & Gyrd-Hansen, Mads, 3 Sep 2018, In: The EMBO Journal. 37, 17Research output: Contribution to journal › Journal article › Research › peer-review
Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.
Gyrd-Hansen, Mads, Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, In: Journal of the Neurological Sciences. 197, 1-2, p. 27-35 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency
Dziadzio, M., Ammann, S., Canning, C., Boyle, F., Hassan, A., Cale, C., Elawad, M., Fiil, Berthe Katrine, Gyrd-Hansen, Mads, Salzer, U., Speckmann, C. & Grimbacher, B., 25 Jul 2015, In: Journal of Clinical Immunology. 35, 5, p. 439-444 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation
Hrdinka, M. & Gyrd-Hansen, Mads, 19 Oct 2017, In: Molecular Cell. 68, 2, p. 265-280 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Met1-linked ubiquitin machinery in inflammation and infection
Fiil, Berthe Katrine & Gyrd-Hansen, Mads, 2021, In: Cell Death and Differentiation. 28, p. 557–569Research output: Contribution to journal › Review › Research › peer-review
- Published
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase
Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd-Hansen, Mads, Pilotte, L., Vigneron, N., De Plaen, E. & Van den Eynde, B. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 23, p. e2022447118Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M. & 10 others, , 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, Mads & Jost, P. J., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1796-1808Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4000197
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Molecular basis and regulation of OTULIN-LUBAC interaction
Research output: Contribution to journal › Journal article › Research › peer-review
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The Met1-linked ubiquitin machinery in inflammation and infection
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Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Research output: Contribution to journal › Journal article › Research › peer-review
Published