Kei Sakamoto
Professor
Sakamoto Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- 1996
Creatine kinase release from regenerated muscles after eccentric contractions in rats
Sakamoto, Kei, Nosaka, K., Shimegi, S., Ohmori, H. & Katsuta , S., 1 Jan 1996, In: European Journal of Applied Physiology and Occupational Physiology. 73, 6, p. 516-520 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
Loss of sarcoplasmic reticulum membrane integrity after eccentric contractions
Yasuda, T., Sakamoto, Kei, Nosaka, K., Wada, M. & Katsuta, S., 1 Jan 1997, p. 581-582. 2 p.Research output: Contribution to conference › Conference abstract for conference › Research
- 1998
Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study
Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M. & Sakamoto, Kei, 1 Jan 1998, In: Acta Neuropathologica. 95, 2, p. 123-130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles
Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, Kei & Totsuka, T., 5 Aug 1999, In: Biochimica et Biophysica Acta - General Subjects. 1428, 2-3, p. 284-292 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Changes in plasma enzyme activity after intramuscular injection of bupivacaine into the human biceps brachii
Nosaka, K. & Sakamoto, Kei, 1 Dec 1999, In: Acta Physiologica Scandinavica. 167, 3, p. 259-265 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats
Sakuma, K., Watanabe, K., Sano, M., Kitajima, S., Sakamoto, Kei, Uramoto, I. & Totsuka, T., Feb 2000, In: Acta Neuropathologica. 99, 2, p. 177-185 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Changes in Leukocytes after Eccentric Exerclse ot the Elbow Flexors
Nosaka, K. & Sakamoto, Kei, 25 May 2000, In: Advances in Exercise and Sports Physiology. 6, 2, p. 59-65 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise
Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors
Nosaka, K. & Sakamoto, Kei, 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 1, p. 22-29 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
How long does the protective effect on eccentric exercise-induced muscle damage last?
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 9, p. 1490-1495 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: European Journal of Applied Physiology. 85, 1-2, p. 34-40 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle
Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358Research output: Contribution to journal › Journal article › Research › peer-review
Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line
Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Effect of AICAR treatment on glycogen metabolism in skeletal muscle
Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Invited review: Intracellular signaling in contracting skeletal muscle
Sakamoto, Kei & Goodyear, L. J., 1 Jan 2002, In: Journal of Applied Physiology. 93, 1, p. 369-383 15 p.Research output: Contribution to journal › Review › Research › peer-review
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, Kei, Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C. & Ronald Kahn, C., 1 Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 141-149 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Influence of Arm-cranking on Changes in Plasma CK Activity after High Force Eccentric Exercise of the Elbow Flexors
Nosaka, K., Sakamoto, Kei & Newton, M., 25 Mar 2002, In: Advances in Exercise and Sports Physiology. 8, 2, p. 45-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Contraction regulation of Akt in rat skeletal muscle
Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G. & Goodyear, L. J., 5 Apr 2002, In: Journal of Biological Chemistry. 277, 14, p. 11910-11917 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insulin signaling after exercise in insulin receptor substrate-2-deficient mice
Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
Stoppani, J., Hildebrandt, A. L., Sakamoto, Kei, Cameron-Smith, D., Goodyear, L. J. & Darrell Neufer, P., 1 Dec 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 283, 6 46-6, p. E1239-E1248Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
Akt signaling in skeletal muscle: Regulation by exercise and passive stretch
Sakamoto, Kei, Aschenbach, W. G., Hirshman, M. F. & Goodyear, L. J., 1 Nov 2003, In: American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1081-E1088Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise
Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.Research output: Contribution to journal › Review › Research › peer-review
Influence of pre-exercise muscle temperature on responses to eccentric exercise
Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Apr 2004, In: Journal of Athletic Training. 39, 2, p. 132-137 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle
Sakamoto, Kei, Arnolds, D. E. W., Ekberg, I., Thorell, A. & Goodyear, L. J., 25 Jun 2004, In: Biochemical and Biophysical Research Communications. 319, 2, p. 419-425 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208Research output: Contribution to journal › Journal article › Research › peer-review
Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR
Sakamoto, Kei, Göransson, O., Hardie, D. G. & Alessi, D. R., 1 Aug 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E310-E317Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
McManus, E. J., Sakamoto, Kei, Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R., 20 Apr 2005, In: EMBO Journal. 24, 8, p. 1571-1583 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Sakamoto, Kei, McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R., 18 May 2005, In: EMBO Journal. 24, 10, p. 1810-1820 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
Mora, A., Sakamoto, Kei, McManus, E. J. & Alessi, D. R., 27 Jul 2005, In: FEBS Letters. 579, 17, p. 3632-3638 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle
Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, Kei, Hajduch, E., Arthur, J. S. C. & Hundal, H. S., 1 Nov 2005, In: Diabetes. 54, 11, p. 3161-3168 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
AMPK: A key sensor of fuel and energy status in skeletal muscle
Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.Research output: Contribution to journal › Review › Research › peer-review
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
Sakamoto, Kei, Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanović, A., Alessi, D. R. & Bertrand, L., 1 May 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 290, 5, p. E780-E788Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle
Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, Kei, Hirshman, M. F. & Goodyear, L. J., 1 Jul 2006, In: Diabetes. 55, 7, p. 2067-2076 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway
Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158Research output: Contribution to journal › Journal article › Research › peer-review
LKB1-dependent signaling pathways
Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.Research output: Contribution to journal › Review › Research › peer-review
Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise
Howlett, K. F., Sakamoto, Kei, Yu, H., Goodyear, L. J. & Hargreaves, M., 1 Aug 2006, In: Metabolism: Clinical and Experimental. 55, 8, p. 1046-1052 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Evaluation of approaches to generation of tissue-specific knock-in mice
Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle
Sakamoto, Kei, Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F. & Goodyear, L. J., 24 Nov 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 5, p. E1031-E1037Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels
Sukhodub, A., Jovanović, S., Qingyou, D. U., Budas, G., Clelland, A. K., Shen, M. E. I., Sakamoto, Kei, Tian, R. & Jovanović, A., 1 Jan 2007, In: Journal of Cellular Physiology. 210, 1, p. 224-236 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study
Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., Sakamoto, Kei & Musi, N., 1 Mar 2007, In: Diabetes. 56, 3, p. 836-848 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle
Howlett, K. F., Sakamoto, Kei, Garnham, A., Cameron-Smith, D. & Hargreaves, M., 1 Jun 2007, In: Diabetes. 56, 6, p. 1608-1614 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle
Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35Research output: Contribution to journal › Journal article › Research › peer-review
Silencing Metabolic Disorders by Novel SIRT1 Activators
Sakamoto, Kei, 9 Jan 2008, In: Cell Metabolism. 7, 1, p. 3-4 2 p.Research output: Contribution to journal › Letter › Research › peer-review
The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle
Howlett, K. F., Mathews, A., Garnham, A. & Sakamoto, Kei, 1 Feb 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 2, p. E401-E407Research output: Contribution to journal › Journal article › Research › peer-review
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle
Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, Kei & Kawanaka, K., 1 Jun 2008, In: Metabolism: Clinical and Experimental. 57, 6, p. 749-756 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Huang, X., Wullschleger, S., Shpiro, M., McGuire, V. A., Sakamoto, Kei, Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 211-221 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
Sakamoto, Kei & Holman, G. D., 1 Jul 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 1, p. E29-E37Research output: Contribution to journal › Review › Research › peer-review
- Published
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, Kei & Hundal, H. S., 10 Oct 2008, In: Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulating the Motor for GLUT4 Vesicle Traffic
Holman, G. D. & Sakamoto, Kei, 5 Nov 2008, In: Cell Metabolism. 8, 5, p. 344-346 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, Kei & Hardie, D. G., 15 Nov 2008, In: Biochemical Journal. 416, 1, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy
Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, Kei, Foretz, M. & Viollet, B., Jul 2009, In: FASEB Journal. 23, 7, p. 2264-2273 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators
Guigas, B., Sakamoto, Kei, Taleux, N., Reyna, S. M., Musi, N., Viollet, B. & Hue, L., 1 Dec 2009, In: IUBMB Life. 61, 1, p. 18-26 9 p.Research output: Contribution to journal › Review › Research › peer-review
- 2010
- Published
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, Kei, Andreelli, F. & Viollet, B., 1 Jul 2010, In: Journal of Clinical Investigation. 120, 7, p. 2355-2369 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle
Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., Van Diepen, J. A., Voshol, P. J., Jensen, J. & Sakamoto, Kei, 3 Nov 2010, In: Cell Metabolism. 12, 5, p. 456-466 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle
Hunter, R. W., Treebak, Jonas Thue, Wojtaszewski, Jørgen F P & Sakamoto, Kei, 2011, In: Diabetes. 60, 3, p. 766-774 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes
Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
Wullschleger, S., Sakamoto, Kei, Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., 1 Jan 2011, In: DMM Disease Models and Mechanisms. 4, 1, p. 95-103 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking
Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, Kei, 5 Jan 2011, In: Cell Metabolism. 13, 1, p. 68-79 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways
Richardson, C., Sakamoto, Kei, De Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In: Journal of Cell Science. 124, 5, p. 789-800 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P2 in regulating insulin sensitivity defined by knock-in analysis
Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, Kei & Alessi, D. R., 1 Mar 2011, In: Biochemical Journal. 434, 2, p. 265-274 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase
Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, Kei & Hundal, H. S., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 463-474 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protor-1 is required for efticient mT0RC2-mediated activation of SGK1 in the kidney
Pearce, L. R., Sommer, E. M., Sakamoto, Kei, Wullschleger, S. & Alessi, D. R., 15 May 2011, In: Biochemical Journal. 436, 1, p. 169-179 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
Kim, A. S., Miller, E. J., Wright, T. M., Li, J., Qi, D., Atsina, K., Zaha, V., Sakamoto, Kei & Young, L. H., 1 Jul 2011, In: Journal of Molecular and Cellular Cardiology. 51, 1, p. 24-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P. P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, Kei, Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. & Brunet, A., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 878-892 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle
Joanne, P., Hourdé, C., Ochala, J., Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamoto, Kei, Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 2012, In: PLoS ONE. 7, 4, p. e35346Research output: Contribution to journal › Journal article › Research › peer-review
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase
Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, Kei, Hue, L. & Rider, M. H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 193-203 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Thr 649 Ala-AS160 knock-in mutation does not impair contraction/ AICAR-induced glucose transport in mouse muscle
Ducommun, S., Wang, H. Y., Sakamoto, Kei, MacKintosh, C. & Chen, S., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1036-E1043Research output: Contribution to journal › Journal article › Research › peer-review
The ancient drug salicylate directly activates AMP-activated protein kinase
Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, Kei, Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
Din, F. V. N., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, Kei, Alessi, D. R. & Dunlop, M. G., Jun 2012, In: Gastroenterology. 142, 7, p. 1504-1515.e3Research output: Contribution to journal › Journal article › Research › peer-review
Cellular responses to the metal-binding properties of metformin
Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, Kei, Prescott, A. R. & Rena, G., 1 Jun 2012, In: Diabetes. 61, 6, p. 1423-1433 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes
Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, Kei & Göransson, O., 15 Jun 2012, In: Biochemical Journal. 444, 3, p. 503-514 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects
Jensen, J., Tantiwong, P., Stuenæs, J. T., Molina-Carrion, M., de Fronzo, R. A., Sakamoto, Kei & Musi, N., 1 Jul 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 1, p. E82-E89Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase
Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E. & Sakamoto, Kei, 1 Nov 2012, In: Cellular Signalling. 24, 11, p. 2085-2094 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise
Li, M., Verdijk, L. B., Sakamoto, Kei, Ely, B., van Loon, L. J. C. & Musi, N., 1 Nov 2012, In: Mechanisms of Ageing and Development. 133, 11-12, p. 655-664 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
LKB1 regulates lipid oxidation during exercise independently of AMPK
Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, Andreas Mæchel, Pehmøller, C., Sylow, Lykke, Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, Clara, Qvortrup, Klaus, Dyck, J. R. B., Hunter, R. W., Sakamoto, Kei, Thomson, D. M., Schjerling, Peter, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues
Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, Kei, Mackintosh, C. & Chen, S., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 479-489 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin α∥bβ3 activation and granule secretion in platelets
Moore, S. F., Van Den Bosch, M. T. J., Hunter, R. W., Sakamoto, Kei, Poole, A. W. & Hers, I., 8 Feb 2013, In: Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition
Wan, M., Leavens, K. F., Hunter, R. W., Koren, S., Von Wilamowitz-Moellendorff, A., Lu, M., Satapati, S., Chu, Q., Sakamoto, Kei, Burgess, S. C. & Birnbaum, M. J., 2 Jul 2013, In: Cell Metabolism. 18, 1, p. 99-105 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, Kei, Foretz, M., Viollet, B. & Chazaud, B., 6 Aug 2013, In: Cell Metabolism. 18, 2, p. 251-264 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular mechanism of action of metformin: Old or new insights?
Rena, G., Pearson, E. R. & Sakamoto, Kei, 1 Sep 2013, In: Diabetologia. 56, 9, p. 1898-1906 9 p.Research output: Contribution to journal › Review › Research › peer-review
Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis
Von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, Kei, 1 Dec 2013, In: Diabetes. 62, 12, p. 4070-4082 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells
De Meester, C., Timmermans, A. D., Balteau, M., Ginion, A., Roelants, V., Noppe, G., Porporato, P. E., Sonveaux, P., Viollet, B., Sakamoto, Kei, Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & Bertrand, L., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 20-29 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Salicylic acid: old and new implications for the treatment of type 2 diabetes?
Rena, G. & Sakamoto, Kei, 1 Jan 2014, In: Diabetology International. 5, 4, p. 212-218 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of LKB1 Ser431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
Houde, V. P., Ritorto, M. S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, Kei & Alessi, D. R., 15 Jan 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage
Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y. Y., Kolwicz, S. C., Xu, J., Sakamoto, Kei, Wang, W. & Tian, R., 14 Mar 2014, In: Circulation Research. 114, 6, p. 966-975 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
Ducommun, S., Ford, R. J., Bultot, L., Deak, M., Bertrand, L., Kemp, B. E., Steinberg, G. R. & Sakamoto, Kei, 15 Mar 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 6, p. E688-E696Research output: Contribution to journal › Journal article › Research › peer-review
The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets
Onselaer, M. B., Oury, C., Hunter, R. W., Eeckhoudt, S., Barile, N., Lecut, C., Morel, N., Viollet, B., Jacquet, L. M., Bertrand, L., Sakamoto, Kei, Vanoverschelde, J. L., Beauloye, C. & Horman, S., Jun 2014, In: Journal of Thrombosis and Haemostasis. 12, 6, p. 973-986 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake
Timmermans, A. D., Balteau, M., Gélinas, R., Renguet, E., Ginion, A., de Meester, C., Sakamoto, Kei, Balligand, J. L., Bontemps, F., Vanoverschelde, J. L., Horman, S., Beauloye, C. & Bertrand, L., 15 Jun 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 306, 12, p. H1619-H1630Research output: Contribution to journal › Journal article › Research › peer-review
Structural basis for the recruitment of glycogen synthase by glycogenin
Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, Kei & Sicheri, F., 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840Research output: Contribution to journal › Journal article › Research › peer-review
Mechanism of action of compound-13: An α1-selective small molecule activator of AMPK
Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, Kei, 17 Jul 2014, In: Chemistry and Biology. 21, 7, p. 866-879 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, Kei, 4 Aug 2014, In: Nature Communications. 5, 4535.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes
Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, Andreas Mæchel, Foretz, M., Campbell, D. G., Sakamoto, Kei, Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells
Hunter, R. W., Zeqiraj, E., Morrice, N., Sicheri, F. & Sakamoto, Kei, Apr 2015, In: Protein Expression and Purification. 108, p. 23-29 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate
Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16
Shehata, S. N., Deak, M., Morrice, N. A., Ohta, E., Hunter, R. W., Kalscheuer, V. M. & Sakamoto, Kei, 1 Aug 2015, In: Biochemical Journal. 469, 3, p. 409-420 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion
Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 227976158
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Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle
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Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates
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Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
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