Anne Tybjærg-Hansen
Clinical Professor
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Long-term Benefits and Harms Associated with Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population
Nordestgaard, L. T., Christoffersen, M., Lauridsen, B. K., Afzal, Shoaib, Nordestgaard, Børge, Frikke-Schmidt, Ruth & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 1, p. 55-64Research output: Contribution to journal › Journal article › Research › peer-review
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Macular Degeneration and CETP Inhibition-Reply
Nordestgaard, L. T., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2022, In: JAMA Cardiology. 7, 7, p. 775-776 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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High-throughput genotyping of copy number variation in glutathione S-transferases M1 and T1 using real-time PCR in 20,687 individuals
Norskov, M. S., Frikke-Schmidt, Ruth, Loft, Steffen & Tybjærg-Hansen, Anne, 2009, In: Clinical Biochemistry. 42, 3, p. 201-209 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glutathione S-transferases T1 and M1 and asthma risk in 10,000 individuals and in meta-analysis
Norskov, M., Dahl, Morten & Tybjærg-Hansen, Anne, 1 Sep 2013.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Copy number variation in glutathione-S-transferase T1 and M1 predicts incidence and 5-year survival from prostate and bladder cancer, and incidence of corpus uteri cancer in the general population
Nørskov, M. S., Frikke-Schmidt, Ruth, Bojesen, Stig Egil, Nordestgaard, Børge, Loft, Steffen & Tybjærg-Hansen, Anne, 2011, In: Pharmacogenomics Journal. 11, 4, p. 292-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
Nørskov, M. S., Frikke-Schmidt, Ruth, Loft, Steffen, Sillesen, Henrik, Grande, P., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2011, In: Circulation: Cardiovascular Genetics. 4, 4, p. 418-28 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in GSTP1, Lung Function, Risk of Lung Cancer, and Mortality
Nørskov, M. S., Dahl, Morten & Tybjærg-Hansen, Anne, Nov 2017, In: Journal of Thoracic Oncology. 12, 11, p. 1664-1672 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans
Oldoni, F., van Capelleveen, J. C., Dalila, N., Wolters, J. C., Heeren, J., Sinke, R. J., Hui, D. Y., Dallinga-Thie, G. M., Frikke-Schmidt, Ruth, Hovingh, K. G., van de Sluis, B., Tybjærg-Hansen, Anne & Kuivenhoven, J. A., 2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 7, p. 1440-1453 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts
Palmer, T. M., Nordestgaard, Børge, Benn, Marianne, Tybjærg-Hansen, Anne, Davey Smith, G., Lawlor, D. A. & Timpson, N. J., 2013, In: B M J (Online). 347, p. 1-10 10 p., f4262.Research output: Contribution to journal › Journal article › Research › peer-review
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Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies
Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, K. G. M., van der Schouw, Y. T., Selmer, R., Khaw, K-T., Gudnason, V., Assmann, G., Amouyel, P., Salomaa, V., Kivimaki, M., Nordestgaard, B. G., Blaha, M. J. & 255 others, , 2019, In: European Heart Journal. 40, 7, p. 621-631 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma
Praveen, K., Patel, G. C., Gurski, L., Ayer, A. H., Persaud, T., Still, M. D., Miloscio, L., Van Zyl, T., Di Gioia, S. A., Brumpton, B., Krebs, K., Åsvold, B. O., Chen, E., Chavali, V. R. M., Fury, W., Gudiseva, H. V., Hyde, S., Jorgenson, E., Lefebvre, S., Li, D. & 37 others, , 2022, In: Communications Biology . 5, 15 p., 1051.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease
Qayyum, F., Lauridsen, B. K., Frikke-Schmidt, Ruth, Kofoed, Klaus Fuglsang, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 22, p. 2106-2116 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A framework for quantifying net benefits of alternative prognostic models
Rapsomaniki, E., White, I. R., Wood, A. M., Thompson, S. G., Emerging Risk Factors Collaboration, E. R. F. C., ATH, A. & Tybjærg-Hansen, Anne, 2012, In: Statistics in Medicine. 31, 2, p. 114-30 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Jan 2018, In: Alzheimer's & Dementia. 14, 1, p. 71-80Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105949 individuals from a white general population cohort
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 1 Sep 2019, In: European Heart Journal. 40, 33, p. 2813-2824 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Mar 2016, In: Data in Brief. 6, p. 923-932 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration
Rasmussen, Katrine Laura, Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2023, In: JAMA Ophthalmology. 141, 1, p. 13-21 9 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Plasma levels of apolipoprotein E and risk of dementia in the general population
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Feb 2015, In: Annals of Neurology. 77, 2, p. 301-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Mar 2016, In: Atherosclerosis. 246, p. 63-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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APOE and dementia – resequencing and genotyping in 105,597 individuals
Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2020, In: Alzheimer's and Dementia. 16, 12, p. 1624-1637 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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APOE and vascular disease: Sequencing and genotyping in general population cohorts
Rasmussen, Katrine Laura, Luo, J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: Atherosclerosis. 385, 9 p., 117218.Research output: Contribution to journal › Journal article › Research › peer-review
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Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population.
Ravn, L. S., Benn, M., Nordestgaard, B. G., Sethi, A. A., Agerholm-Larsen, B., Jensen, G. B., Tybjaerg-Hansen, A. & Tybjærg-Hansen, Anne, 2008, In: Pharmacogenetics and Genomics. 18, 6, p. 525-33 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population
Ravn, L. S., Benn, Marianne, Nordestgaard, Børge, Sethi, A. A., Agerholm-Larsen, B., Jensen, G. B. & Tybjærg-Hansen, Anne, 2008, In: Pharmacogenetics and Genomics (Print Edition). 18, 6, p. 525-533 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile
Rimbert, A., Yeung, M. W., Dalila, N., Thio, C. H. L., Yu, H., Loaiza, N., Oldoni, F., van der Graaf, A., Wang, S., Said, M. A., Blauw, L. L., Girardeau, A., Bray, L., Caillaud, A., Bloks, V. W., Marrec, M., Mouli, P., Rensen, P. C. N., van de Sluis, B., Snieder, H. & 6 others, , 2022, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 42, 10, p. 1262-1271 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor
Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., Van Der Veen, Y., Singla, A., Van Dijk, F., Frikke-Schmidt, Ruth, Burstein, E., Tybjærg-Hansen, Anne, Van De Sluis, B. & Kuivenhoven, J. A., 2020, In: European Heart Journal. 41, 9, p. 1040-1053 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The influence of genotype on vascular endothelial growth factor and regulation of myocardial collateral blood flow in patients with acute and chronic coronary heart disease
Ripa, R. S., Jorgensen, E., Baldazzi, F., Frikke-Schmidt, Ruth, Wang, Y., Tybjærg-Hansen, Anne & Kastrup, J., 2009, In: Scandinavian Journal of Clinical & Laboratory Investigation. 69, 6, p. 722-728 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society
Roeters Van Lennep, J. E., Tokgözoǧlu, L. S., Badimon, L., Dumanski, S. M., Gulati, M., Hess, C. N., Holven, K. B., Kavousi, M., Kaylkçloǧlu, M., Lutgens, E., Michos, E. D., Prescott, Eva, Stock, J. K., Tybjærg-Hansen, Anne, Wermer, M. J. H. & Benn, Marianne, 2023, In: European Heart Journal. 44, 39, p. 4157-4173 17 p.Research output: Contribution to journal › Review › Research › peer-review
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Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
Sarwar, N., Gao, P., Seshasai, S. R. K., Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D. A., Selvin, E., Stampfer, M., Stehouwer, C. D. A., Lewington, S., Pennells, L., Thompson, A., Sattar, N., White, I. R., Ray, K. K., Danesh, J., Jørgensen, T., Emerging Risk Factors Collaboration & 3 others, , 26 Jun 2010, In: Lancet. 375, 9733, p. 2215-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
Sarwar, N., Sandhu, M. S., Ricketts, S. L., Butterworth, A. S., Di Angelantonio, E., Boekholdt, S. M., Ouwehand, W., Watkins, H., Samani, N. J., Saleheen, D., Lawlor, D., Reilly, M. P., Hingorani, A. D., Talmud, P. J., Danesh, J., Jørgensen, T., Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, T. C. D. G. C. A. E. R. F. C., Tybjærg-Hansen, Anne, Frikke-Schmidt, R. & Nordestgaard, Børge, 8 May 2010, In: Lancet. 375, 9726, p. 1634-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., Gorman, D. N., Gao, P., Saleheen, D., Rendon, A., Nelson, C. P., Braund, P. S., Hall, A. S., Chasman, D. I., Tybjærg-Hansen, A., Chambers, J. C., Benjamin, E. J., Franks, P. W., Clarke, R., Wilde, A. A. M., Trip, M. D. & 31 others, , 31 Mar 2012, In: Lancet. 379, 9822, p. 1205-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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ABC transporter genes and risk of type 2 diabetes: a study of 40,000 individuals from the general population
Schou, J., Tybjærg-Hansen, Anne, Møller, H. J., Nordestgaard, Børge & Frikke-Schmidt, R., 2012, In: Diabetes Care. 35, 12, p. 2600-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation in ABCG1 and Risk of Myocardial Infarction and Ischemic Heart Disease
Schou, J., Frikke-Schmidt, R., Kardassis, D., Thymiakou, E., Nordestgaard, Børge, Jensen, G., Grande, P. & Tybjærg-Hansen, Anne, 2012, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 32, p. 506-15 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A rare genetic variant in the manganese transporter SLC30A10 and elevated liver enzymes in the general population
Seidelin, A. S., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Yaghootkar, H. & Stender, Stefan, 2022, In: Hepatology International. 16, 3, p. 702-711Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose
Seidelin, A., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Stender, S., 2020, In: Journal of Clinical Endrocrinology and Metabolism. 105, 6, p. 1963–1972Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes mellitus, fasting glucose, and risk of cause-specific death
Seshasai, S. R. K., Kaptoge, S., Thompson, A., Di Angelantonio, E., Gao, P., Sarwar, N., Whincup, P. H., Mukamal, K. J., Gillum, R. F., Holme, I., Njølstad, I., Fletcher, A., Nilsson, C. M. P., Lewington, S., Collins, R., Gudnason, V., Thompson, S. G., Sattar, N., Selvin, E., Hu, F. B. & 7 others, , 2011, In: New England Journal of Medicine. 364, 9, p. 829-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
Sethi, A., Tybjærg-Hansen, A., Jensen, G. B., Nordestgaard, B., Tybjærg-Hansen, Anne & Nordestgaard, Børge, 2005, In: Pharmacogenetics and Genomics. 15, 9, p. 633-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High pre-beta1 HDL concentrations and low lecithin: cholesterol acyltransferase activities are strong positive risk markers for ischemic heart disease and independent of HDL-cholesterol
Sethi, A. A., Sampson, M., Warnick, R., Muniz, N., Vaisman, B., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Remaley, A. T., 1 Jul 2010, In: Clinical Chemistry. 56, 7, p. 1128-37 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis
Singh, G. M., Danaei, G., Farzadfar, F., Stevens, G. A., Woodward, M., Wormser, D., Kaptoge, S., Whitlock, G., Qiao, Q., Lewington, S., Di Angelantonio, E., Vander Hoorn, S., Lawes, C. M. M., Ali, M. K., Mozaffarian, D., Ezzati, M., Tybjærg-Hansen, Anne, Frikke-Schmidt, Ruth, Benn, Marianne & Nordestgaard, Børge, Jul 2013, In: P L o S One. 8, 7, p. 1-10 10 p., e65174.Research output: Contribution to journal › Journal article › Research › peer-review
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Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement
Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Yarmolinsky, J., Davies, N. M., Swanson, S. A., Vanderweele, T. J., Higgins, J. P. T., Timpson, N. J., Dimou, N., Langenberg, C., Golub, R. M., Loder, E. W., Gallo, V., Tybjærg-Hansen, Anne, Davey Smith, G., Egger, M. & Richards, J. B., 2021, In: JAMA - Journal of the American Medical Association. 326, 16, p. 1614-1621Research output: Contribution to journal › Journal article › Research › peer-review
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Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays
Smith, F. A., Howard, P., Shah, S., Eriksson, P., Stender, S., Giambartolomei, C., Folkersen, L. W., Tybjærg-Hansen, Anne, Kumari, M., Palmen, J., Hingorani, A. D., Talmud, P. J. & Humphries, S. E., 2012, In: P L o S Genetics. 8, 8, p. e1002908Research output: Contribution to journal › Journal article › Research › peer-review
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Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism
Steiner, C., Holleboom, A. G., Karuna, R., Motazacker, M. M., Kuivenhoven, J. A., Frikke-Schmidt, R., Tybjærg-Hansen, Anne, Rohrer, L., Rentsch, K. M. & von Eckardstein, A., 2012, In: Clinical Science. 122, 8, p. 385-96 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation in liver x receptor alpha and risk of ischemic vascular disease in the general population
Stender, S., Frikke-Schmidt, R., Anestis, A., Kardassis, D., Sethi, A. A., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 12, p. 2990-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population
Stender, S., Frikke-Schmidt, R., Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2011, In: Hepatology. 53, 2, p. 640-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Extreme Bilirubin Levels as a Causal Risk Factor for Symptomatic Gallstone Disease
Stender, Stefan, Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2013, In: Annals of Internal Medicine. 173, 13, p. 1222-1228 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci
Stender, S., Kozlitina, J., Nordestgaard, Børge, Tybjærg-Hansen, Anne, Hobbs, H. H. & Cohen, J. C., Jun 2017, In: Nature Genetics. 49, 6, p. 842-847 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
Stender, S., Smagris, E., Lauridsen, B. K., Kofoed, Klaus Fuglsang, Nordestgaard, Børge, Tybjærg-Hansen, Anne, Pennacchio, L. A., Dickel, D. E., Cohen, J. C. & Hobbs, H. H., 2018, In: Hepatology. 67, 6, p. 2182-2195 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The ABCG5/8 Cholesterol Transporter and Myocardial Infarction Versus Gallstone Disease
Stender, S., Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2014, In: Journal of the American College of Cardiology. 63, 20, p. 2121-2128 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis
Stender, S., Frikke-Schmidt, R., Nordestgaard, Børge, Grande, P. & Tybjærg-Hansen, Anne, 2013, In: The Internet Journal of Internal Medicine. 273, 1, p. 59-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to: liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease
Stender, S. & Tybjærg-Hansen, Anne, 2018, In: European Heart Journal. 39, 36, p. 3399Research output: Contribution to journal › Comment/debate › Research › peer-review
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Elevated body mass index as a causal risk factor for symptomatic gallstone disease: A Mendelian randomization study
Stender, Stefan, Nordestgaard, B. G. & Tybjærg-Hansen, Anne, 2013, In: Hepatology. 58, 6, p. 2133–2141Research output: Contribution to journal › Journal article › Research › peer-review
ID: 924951
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ABCA7 and risk of dementia and vascular disease in the Danish population
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The UK10K project identifies rare variants in health and disease
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Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease
Research output: Contribution to journal › Journal article › Research › peer-review
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