Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Research output: Contribution to journal › Journal article › Research › peer-review

  • Nadeem Sarwar
  • Adam S Butterworth
  • Daniel F Freitag
  • John Gregson
  • Peter Willeit
  • Donal N Gorman
  • Pei Gao
  • Danish Saleheen
  • Augusto Rendon
  • Christopher P Nelson
  • Peter S Braund
  • Alistair S Hall
  • Daniel I Chasman
  • Tybjærg-Hansen, Anne
  • John C Chambers
  • Emelia J Benjamin
  • Paul W Franks
  • Robert Clarke
  • Arthur A M Wilde
  • Mieke D Trip
  • Maristella Steri
  • Jacqueline C M Witteman
  • Lu Qi
  • C Ellen van der Schoot
  • Ulf de Faire
  • Jeanette Erdmann
  • Heather M Stringham
  • Wolfgang Koenig
  • Daniel J Rader
  • David Melzer
  • David Reich
  • Bruce M Psaty
  • Marcus E Kleber
  • Demosthenes B Panagiotakos
  • Johann Willeit
  • Patrik Wennberg
  • Mark Woodward
  • Svetlana Adamovic
  • Eric B Rimm
  • Tom W Meade
  • Richard F Gillum
  • Jonathan A Shaffer
  • Albert Hofman
  • Altan Onat
  • Johan Sundström
  • Sylvia Wassertheil-Smoller
  • Dan Mellström
  • John Gallacher
  • Kristine Højgaard Allin
  • Nordestgaard, Børge
  • IL6R Genetics Consortium Emerging Risk Factors Collaboration
Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.
Original languageEnglish
JournalLancet
Volume379
Issue number9822
Pages (from-to)1205-13
Number of pages9
ISSN0140-6736
DOIs
Publication statusPublished - 31 Mar 2012

    Research areas

  • Causality, Coronary Disease, Gene Frequency, Genetic Variation, Humans, Inflammation Mediators, Receptors, Interleukin-6, Risk Factors, Signal Transduction

ID: 46405461