Tuomas Oskari Kilpeläinen
Associate Professor
Kilpeläinen Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
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SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L-P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 31 others, , 2017, In: Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes
Lohmueller, K. E., Sparsø, T. H., Li, Q., Galijatovic, E. A. A., Korneliussen, T. S., Albrechtsen, A., Banasik, K., Grarup, N., Hallgrimsdottir, I., Kiil, K., Oskari Kilpeläinen, T., Krarup, N. T., Pers, T. H., Sanchez, G., Hu, Y., DeGiorgio, M., Jørgensen, T., Sandbæk, A., Lauritzen, T., Brunak, S. & 6 others, , 5 Dec 2013, In: American Journal of Human Genetics. 93, 6, p. 1072-1086 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genes that make you fat, but keep you healthy
Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Journal of Internal Medicine. 284, 5, p. 450-463 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., Kanoni, S. & 239 others, , 1 Feb 2016, In: Nature Communications. 7, p. 1-15 15 p., 10495.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels
Mahendran, Y., Jonsson, Anna Elisabet, Have, C. T., Allin, K. H., Witte, D. R., Jørgensen, M. E., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 10 Feb 2017, In: Diabetologia. 60, 5, p. 873-878 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
McCaffery, J. M., Jablonski, K. A., Pan, Q., Astrup, A., Christiansen, Malene Revsbech, Corella, D., Corso, L. M. L., Florez, J. C., Franks, P. W., Gardner, C., Hansen, Torben, Kilpeläinen, Tuomas O., Knowler, W. C., Lindström, J., Saris, W. H. M., Sørensen, Thorkild I.A., Tuomilehto, J., Uusitupa, M., Wing, R. R. & Agurs-Collins, T., 2022, In: Diabetes. 71, 4, p. 669-676 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
Merino, J., Guasch-Ferré, M., Ellervik, C., Dashti, H. S., Sharp, S. J., Wu, P., Overvad, K., Sarnowski, C., Kuokkanen, M., Lemaitre, R. N., Justice, A. E., Ericson, U., Braun, K. V. E., Mahendran, Y., Frazier-Wood, A. C., Sun, D., Chu, A. Y., Tanaka, T., Luan, J., Hong, J. & 48 others, , 2019, In: BMJ (Clinical research ed.). 366, p. l4292Research output: Contribution to journal › Journal article › Research › peer-review
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From man to mouse: The discovery and validation of CYR61 as a regulator of body composition
Metz, Sophia, Grevengoed, Trisha Jean, Kilpeläinen, Tuomas O. & Gillum, M. P., 2020, In: European Journal of Human Genetics. 28, SUPPL 1, p. 741-742 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Genetic variation, adipokines, and cardiometabolic disease
Metz, Sophia, Huang, L. O. & Kilpeläinen, Tuomas O., 2020, In: Current Opinion in Pharmacology. 52, p. 33-39 7 p.Research output: Contribution to journal › Review › Research › peer-review
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The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism
Metz, Sophia, Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, Christina, Neville, M. J., Christiansen, Malene Revsbech, Jonsson, Anna Elisabet, Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, Niklas Rye, Karpe, F., Grarup, Niels, Pedersen, Oluf Borbye, Kilpeläinen, Tuomas O. & Hansen, Torben, 2022, In: Journal of the Endocrine Society. 6, 5, 10 p., bvac034.Research output: Contribution to journal › Journal article › Research › peer-review
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Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals
Nead, K. T., Li, A., Wehner, M. R., Neupane, B., Gustafsson, S., Butterworth, A., Engert, J. C., Davis, A. D., Hegele, R. A., Miller, R., den Hoed, M., Khaw, K-T., Oskari Kilpeläinen, T., Wareham, N., Edwards, T. L., Hallmans, G., Varga, T. V., Kardia, S. L. R., Smith, J. A., Zhao, W. & 31 others, , 17 Mar 2015, In: Human Molecular Genetics. 24, 2, p. 3582–3594 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Noordam, R., Bos, M. M., Wang, H., Winkler, T. W., Bentley, A. R., Kilpeläinen, T. O., de Vries, P. S., Sung, Y. J., Schwander, K., Cade, B. E., Manning, A., Aschard, H., Brown, M. R., Chen, H., Franceschini, N., Musani, S. K., Richard, M., Vojinovic, D., Aslibekyan, S., Bartz, T. M. & 128 others, , 2019, In: Nature Communications. 10, 1, 13 p., 5121.Research output: Contribution to journal › Journal article › Research › peer-review
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The Promise of Selecting Individuals from the Extremes of Exposure in the Analysis of Gene-Physical Activity Interactions
Osazuwa-Peters, O. L., Schwander, K., Waken, R. J., de Las Fuentes, L., Kilpeläinen, Tuomas O., Loos, R. J. F., Racette, S. B., Sung, Y. J. & Rao, D. C., 2019, In: Human Heredity. 83, 6, p. 315-332Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study
Kilpeläinen, Tuomas O., Lakka, T. A., Laaksonen, D. E., Mager, U., Salopuro, T., Kubaszek, A., Todorova, B., Laukkanen, O., Lindström, J., Eriksson, J. G., Hämäläinen, H., Aunola, S., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Tuomilehto, J., Laakso, M., Uusitupa, M. & Finnish Diabetes Prevention Study Group, F. D. P. S. G., Mar 2008, In: Metabolism. 57, 3, p. 428-36 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association studies and resting heart rate
Kilpeläinen, Tuomas O., 2016, In: Journal of Electrocardiology. 49, 6, p. 860-863 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Oskari Kilpeläinen, T., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., Styrkarsdottir, U., Zhou, Y., Smith, A. V., Zhao, J-H., Amin, N., Vedantam, S., Shin, S-Y., Haritunians, T., Fu, M., Feitosa, M. F. & 97 others, , Aug 2011, In: Nature Genetics. 43, 8, p. 753-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Common sources of bias in gene-lifestyle interaction studies of cardiometabolic disease
Kilpeläinen, Tuomas O., 29 Sep 2013, In: Current Nutrition Reports. 2, p. 251-257Research output: Contribution to journal › Journal article › Research › peer-review
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Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
Kilpeläinen, Tuomas O., den Hoed, M., Ong, K. K., Grøntved, A., Brage, S., Jameson, K., Cooper, C., Khaw, K., Ekelund, U., Wareham, N. J., Loos, R. J. F. & Early Growth Genetics Consortium, E. G. G. C., Apr 2011, In: American Journal of Clinical Nutrition. 93, 4, p. 851-60 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SNPs in PPARG associate with type 2 diabetes and interact with physical activity
Kilpeläinen, Tuomas O., Lakka, T. A., Laaksonen, D. E., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Lindi, V., Tuomilehto, J., Uusitupa, M. & Laakso, M., Jan 2008, In: Medicine and Science in Sports and Exercise. 40, 1, p. 25-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene-physical activity interactions and their impact on diabetes
Kilpeläinen, Tuomas O. & Franks, P. W., 2014, In: Medicine and Sport Science. 60, p. 94-103 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study
Kilpeläinen, Tuomas O., Bingham, S. A., Khaw, K., Wareham, N. J. & Loos, R. J. F., 15 Sep 2009, In: Human Molecular Genetics. 18, 18, p. 3496-501 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study
Kilpeläinen, Tuomas O., Laaksonen, D. E., Lakka, T. A., Herder, C., Koenig, W., Lindström, J., Eriksson, J. G., Uusitupa, M., Kolb, H., Laakso, M., Tuomilehto, J. & Finnish Diabetes Prevention Study, F. D. P. S., Nov 2010, In: Experimental and Clinical Endocrinology and Diabetes. 118, 10, p. 757-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Kilpeläinen, Tuomas O., Lakka, T. A., Laaksonen, D. E., Laukkanen, O., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Aunola, S., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Tuomilehto, J., Uusitupa, M., Laakso, M. & Finnish Diabetes Prevention Study Group, F. D. P. S. G., 22 Oct 2007, In: Physiological Genomics. 31, 2, p. 264-72 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Oskari Kilpeläinen, T., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., Holzapfel, C., Autenrieth, C. S., Hyppönen, E., Cauchi, S., He, M., Kutalik, Z., Kumari, M., Stancáková, A., Meidtner, K., Balkau, B. & 96 others, , 1 Nov 2011, In: P L o S Medicine (Online). 8, 11, p. e1001116Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association studies (GWAS) of adiposity
Kilpeläinen, Tuomas O. & Ingelsson, E., 2016, The genetics of type 2 diabetes and related traits: Biology, physiology and translation. Florez, J. C. (ed.). 1 ed. Switzerland: Springer, p. 91-109Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
ID: 37677655
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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
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Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents
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Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology
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Published