Mikkel-Ole Skjødt
Associate Professor
Immunology
Blegdamsvej 3B, 2200 København N
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Decreased material-activation of the complement system using low-energy plasma polymerized poly(vinyl pyrrolidone) coatings
Andersen, T. E., Palarasah, Y., Skjødt, Mikkel-Ole, Ogaki, R., Benter, M., Alei, M., Kolmos, H. J., Koch, C. & Kingshott, P., Jul 2011, In: Biomaterials. 32, 20, p. 4481-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pentraxin-3 level at admission is a strong predictor of short-term mortality in a community-based hospital setting
Bastrup-Birk, S., Munthe-Fog, L., Skjødt, Mikkel-Ole, Ma, Y. J., Nielsen, H., Køber, Lars Valeur, Nielsen, Olav Wendelboe, Iversen, Kasper & Garred, Peter, May 2015, In: Journal of Internal Medicine. 277, 5, p. 562-572 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome
Bastrup-Birk, S., Skjødt, Mikkel-Ole, Munthe-Fog, L., Strom, J. J., Ma, Y. J. & Garred, Peter, Sep 2013, In: P L o S One. 8, 9, p. 1-9 9 p., e73119.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency
Bay, J. T., Katzenstein, T. L., Kofoed, K., Patel, D., Skjødt, Mikkel-Ole, Garred, Peter & Schejbel, L., Oct 2015, In: Clinical Immunology. 160, 2, p. 315-8 4 p.Research output: Contribution to journal › Letter › Research › peer-review
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The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization
Bayarri-Olmos, R., Rosbjerg, Anne, Johnsen, L. B., Helgstrand, C., Bak-Thomsen, T., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Biological Chemistry. 296, A13.Research output: Contribution to journal › Journal article › Research › peer-review
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The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
Bayarri-Olmos, R., Johnsen, L. B., Idorn, M., Reinert, L. S., Rosbjerg, Anne, Vang, S., Hansen, Cecilie Bo, Helgstrand, C., Bjelke, J. R., Bak-Thomsen, T., Paludan, S. R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: eLife. 10, 14 p., e70002.Research output: Contribution to journal › Journal article › Research › peer-review
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SARS-CoV-2 neutralizing antibody responses towards full-length spike protein and the receptor-binding domain
Bayarri-Olmos, R., Idorn, M., Rosbjerg, A., Pérez-Alós, L., Hansen, Cecilie Bo, Johnsen, L. B., Helgstrand, C., Zosel, F., Bjelke, J. R., Öberg, F. K., Søgaard, M., Paludan, S. R., Bak-Thomsen, T., Jardine, J. G., Skjødt, Mikkel-Ole & Garred, Peter, 2021, In: Journal of Immunology. 207, 3, p. 878-887 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants
Bayarri-Olmos, R., Jarlhelt, I., Johnsen, L. B., Hansen, Cecilie Bo, Helgstrand, C., Rose Bjelke, J., Matthiesen, F., Nielsen, Susanne Dam, Iversen, Kasper, Ostrowski, Sisse Rye, Bundgård, Henning, Frikke-Schmidt, Ruth, Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Frontiers in Immunology. 12, 757197.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
Bayarri-Olmos, R., Kirketerp-Moller, N., Pérez-Alós, L., Skjodt, K., Skjødt, Mikkel-Ole & Garred, Peter, 2018, In: Frontiers in Immunology. 9, 14 p., 2238.Research output: Contribution to journal › Journal article › Research › peer-review
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Reply to Lassaunière: On the functional characterization of the Y453F RBD variant found in cluster 5 SARS-CoV-2
Bayarri-Olmos, R., Johnsen, L. B., Rosbjerg, Anne, Helgstrand, C., Bak-Thomsen, T., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Biological Chemistry. 297, 5, 101241.Research output: Contribution to journal › Letter › Research
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The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency
Csuka, D., Munthe-Fog, L., Skjødt, Mikkel-Ole, Kocsis, A., Zotter, Z., Gál, P., Varga, L., Farkas, H., Füst, G. & Garred, Peter, 2013, In: Molecular Immunology. 54, 3-4, p. 271-277 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel assay to quantitate MASP-2/ficolin-3 complexes in serum
Csuka, D., Munthe-Fog, L., Skjødt, Mikkel-Ole, Hein, E., Bay, Jakob Thaning, Varga, L., Füst, G. & Garred, Peter, 2013, In: Journal of Immunological Methods. 387, 1-2, p. 237-44 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
Cyranka, L., Mariegaard, I., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Mollnes, T. E., Garred, Peter & Rosbjerg, A., 2023, In: Journal of Innate Immunity. 15, 1, p. 836-849Research output: Contribution to journal › Journal article › Research › peer-review
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Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
Füst, G., Munthe-Fog, L., Illes, Z., Széplaki, G., Molnar, T., Pusch, G., Hirschberg, K., Szegedi, R., Széplaki, Z., Prohászka, Z., Skjødt, Mikkel-Ole & Garred, Peter, 29 Dec 2011, In: Journal of Neuroinflammation. 8, p. 185Research output: Contribution to journal › Journal article › Research › peer-review
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Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens
Götz, M. P., Villegas, M. A. D., Fageräng, B., Kerfin, A., Skjødt, Mikkel-Ole, Garred, Peter & Rosbjerg, Anne, 2024, In: Journal of Immunology. 212, 9, p. 1493-1503Research output: Contribution to journal › Journal article › Research › peer-review
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Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Götz, M. P., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Hansen, Cecilie Bo, Pérez-Alós, L., Jarlhelt, I., Benfield, Thomas, Rosbjerg, Anne & Garred, Peter, 2023, In: Journal of Innate Immunity. 15, 1, p. 122–135Research output: Contribution to journal › Journal article › Research › peer-review
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SARS-CoV-2 antibody responses are correlated to disease severity in COVID-19 convalescent individuals
Hansen, Cecilie Bo, Jarlhelt, I., Pérez-Alós, L., Landsy, L. H., Loftager, M., Rosbjerg, Anne, Helgstrand, C., Bjelke, J. R., Egebjerg, T., Jardine, J. G., Jørgensen, C. S., Iversen, Kasper, Bayarri-Olmos, R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Immunology. 206, 1, p. 109-117 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming
Hansen, Cecilie Bo, Jarlhelt, I., Hasselbalch, R. B., Hamm, S. R., Fogh, K., Pries-Heje, M. M., Møller, D. L., Heftdal, Line Dam, Pérez-Alós, L., Sørensen, E., Larsen, M. A. H., Skjødt, Mikkel-Ole, Ostrowski, Sisse Rye, Frikke-Schmidt, Ruth, Bayarri-Olmos, R., Hilsted, Linda, Bundgård, Henning, Nielsen, Susanne Dam, Iversen, Kasper & Garred, Peter, 2021, In: Journal of Internal Medicine. 290, 6, p. 1272-1274Research output: Contribution to journal › Letter › Research › peer-review
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The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema
Hansen, C. B., Csuka, D., Munthe-Fog, L., Varga, L., Farkas, H., Hansen, K. M., Koch, C., Skjødt, K., Garred, Peter & Skjødt, Mikkel-Ole, 15 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 8, p. 3596-604 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity
Hansen, S., Selman, L., Palaniyar, N., Ziegler, K., Brandt, J., Kliem, A., Jonasson, M., Skjødt, Mikkel-Ole, Nielsen, O., Hartshorn, K., Jørgensen, Thomas, Skjødt, K. & Holmskov, U., 15 Nov 2010, In: Journal of immunology (Baltimore, Md. : 1950). 185, 10, p. 6096-104 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional analysis of Ficolin-3 mediated complement activation
Hein, E., Honoré, C., Skjødt, Mikkel-Ole, Munthe-Fog, L., Hummelshøj, T. & Garred, Peter, 10 Nov 2010, In: PloS one. 5, 11, p. e15443Research output: Contribution to journal › Journal article › Research › peer-review
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Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus
Hein, E., Nielsen, L. A., Nielsen, C. T., Munthe-Fog, L., Skjødt, Mikkel-Ole, Jacobsen, Søren & Garred, Peter, Feb 2015, In: Molecular Immunology. 63, 2, p. 209-214 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities
Hertz, C. E., Bayarri-Olmos, R., Kirketerp-Møller, N., van Putten, S., Pilely, K., Skjødt, Mikkel-Ole & Garred, Peter, 2018, In: Frontiers in Immunology. 9, 13 p., 1945.Research output: Contribution to journal › Journal article › Research › peer-review
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Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain
Honore, C., Rorvig, S., Hummelshoj, T., Skjødt, Mikkel-Ole, Borregaard, N. & Garred, Peter, 1 Jul 2010, In: Journal of Leukocyte Biology. 88, 1, p. 145-158Research output: Contribution to journal › Journal article › Research › peer-review
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The interaction pattern of murine serum ficolin-A with microorganisms
Hummelshøj, T., Ma, Y. J., Munthe-Fog, L., Bjarnsholt, Thomas, Moser, Claus Ernst, Skjødt, Mikkel-Ole, Romani, L., Fujita, T., Endo, Y. & Garred, P., 2012, In: P L o S One. 7, 5, p. 1-12 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
Jarlhelt, I., Nielsen, S. K., Jahn, C. X. H., Hansen, Cecilie Bo, Pérez-Alós, L., Rosbjerg, A., Bayarri-Olmos, R., Skjødt, Mikkel-Ole & Garred, Peter, 2021, In: Frontiers in Immunology. 12, 11 p., 767981.Research output: Contribution to journal › Journal article › Research › peer-review
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The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation
Kozarcanin, H., Lood, C., Fog, L. M., Sandholm, K., Hamad, O. A., Bengtsson, A. A., Skjødt, Mikkel-Ole, Huber-Lang, M., Garred, Peter, Ekdahl, K. N. & Nilsson, B., Mar 2016, In: Journal of Thrombosis and Haemostasis. 14, 3, p. 531-545 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System
Ma, Y. J., Doni, A., Skjødt, Mikkel-Ole, Honore, C., Arendrup, Maiken Cavling, Mantovani, A. & Garred, Peter, 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3405-3417Research output: Contribution to journal › Journal article › Research › peer-review
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Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway
Ma, Y. J., Hein, E., Munthe-Fog, L., Skjødt, Mikkel-Ole, Bayarri-Olmos, R., Romani, L. & Garred, Peter, 1 Oct 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 7, p. 3365-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex
Ma, Y. J., Skjødt, Mikkel-Ole & Garred, Peter, 2013, In: Journal of Innate Immunity. 5, 3, p. 242-250 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation
Munthe-fog, L., Hummelshoj, T., Honoré, C., Moller, M. E., Skjødt, Mikkel-Ole, Palsgaard, I., Borregaard, N., Madsen, H. O. & Garred, Peter, 1 Oct 2012, In: Genes and Immunity. 13, 7, p. 515-522Research output: Contribution to journal › Journal article › Research › peer-review
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Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways
Nordmaj, Mie Anemone, Munthe-Fog, L., Hein, E., Skjødt, Mikkel-Ole & Garred, Peter, Dec 2015, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29, 12, p. 4945-55 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury
Ozaki, M., Kang, Y., Tan, Y. S., Pavlov, V. I., Liu, B., Boyle, D. C., Kushak, R. I., Skjødt, Mikkel-Ole, Grabowski, E. F., Taira, Y. & Stahl, G. L., Oct 2016, In: Kidney International. 90, 4, p. 774-782 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system
Palarasah, Y., Nielsen, C., Sprogøe, U., Christensen, M. L., Lillevang, S., Madsen, H. O., Bygum, A., Koch, C., Skjodt, K. & Skjødt, Mikkel-Ole, Jun 2011, In: Clinical and Experimental Immunology. 164, 3, p. 388-95 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3
Palarasah, Y., Skjodt, K., Brandt, J., Teisner, B., Koch, C., Vitved, L. & Skjødt, Mikkel-Ole, 31 Oct 2010, In: Journal of Immunological Methods. 362, 1-2, p. 142-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sodium polyanethole sulfonate as an inhibitor of activation of complement function in blood culture systems
Palarasah, Y., Skjødt, Mikkel-Ole, Vitved, L., Andersen, T. E., Skjoedt, K. & Koch, C., Mar 2010, In: Journal of Clinical Microbiology. 48, 3, p. 908-14 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis
Pavlov, V. I., Skjødt, Mikkel-Ole, Siow Tan, Y., Rosbjerg, Anne, Garred, Peter & Stahl, G. L., 30 Oct 2012, In: Circulation. Supplement. 126, 18, p. 2227-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques
Pilely, K., Fumagalli, S., Rosbjerg, A., Genster, N., Skjødt, Mikkel-Ole, Perego, C., Ferrante, A. M. R., De Simoni, M. & Garred, Peter, 2017, In: Frontiers in Immunology. 8, 14 p., 1040.Research output: Contribution to journal › Journal article › Research › peer-review
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A specific assay for quantification of human C4c by use of an anti-C4c monoclonal antibody
Pilely, K., Skjødt, Mikkel-Ole, Nielsen, C., Andersen, T. E., Louise Aabom, A., Vitved, L., Koch, C., Skjødt, K. & Palarasah, Y., Mar 2014, In: Journal of Immunological Methods. 405, p. 87-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure
Prohászka, Z., Munthe-Fog, L., Ueland, T., Gombos, T., Yndestad, A., Förhécz, Z., Skjødt, Mikkel-Ole, Pozsonyi, Z., Gustavsen, A., Jánoskuti, L., Karádi, I., Gullestad, L., Dahl, C. P., Askevold, E. T., Füst, G., Aukrust, P., Mollnes, T. E. & Garred, Peter, 2013, In: P L o S One. 8, 4, p. 1-9 9 p., e60976.Research output: Contribution to journal › Journal article › Research › peer-review
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Combining MAP-1:CD35 or MAP-1:CD55 fusion proteins with pattern-recognition molecules as novel targeted modulators of the complement cascade
Pérez-Alós, L., Bayarri-Olmos, R., Skjødt, Mikkel-Ole & Garred, Peter, 2019, In: F A S E B Journal. 33, 11, p. 12723-12734 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MASP-1 and MASP-3 bind directly to aspergillus fumigatus and promote complement activation and phagocytosis
Rosbjerg, Anne, Würzner, R., Garred, Peter & Skjødt, Mikkel-Ole, 2021, In: Journal of Innate Immunity. 13, 4, p. 211-224 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Heterocomplex Formation between MBL/Ficolin/CL-11–Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11–Associated Protein-1
Rosbjerg, A., Munthe-Fog, L., Garred, Peter & Skjødt, Mikkel-Ole, 2014, In: Journal of immunology (Baltimore, Md. : 1950). 192, 9, p. 4352-60 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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THE PATTERN RECOGNITION MOLECULES MBL AND C1Q DETACH FROM THEIR PATHOGEN LIGANDS UPON COMPLEMENT ACTIVATION
Rosbjerg, Anne, Garred, Peter & Skjødt, Mikkel-Ole, 2019, In: Molecular Immunology. 114, p. 490-490Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study
Schoos, M. M., Munthe-Fog, L., Skjødt, Mikkel-Ole, Ripa, Rasmus Sejersten, Lønborg, Jacob Thomsen, Kastrup, J., Kelbæk, H., Clemmensen, P. & Garred, Peter, Jul 2013, In: Molecular Immunology. 54, 3-4, p. 408-14 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
Skjødt, Mikkel-Ole, Hummelshoj, T., Palarasah, Y., Honore, C., Koch, C., Skjodt, K. & Garred, Peter, 12 Mar 2010, In: Journal of Biological Chemistry. 285, 11, p. 8234-8243 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)
Skjødt, Mikkel-Ole, Roversi, P., Hummelshoj, T., Palarasah, Y., Rosbjerg, Anne, Johnson, S., Lea, S. M. & Garred, Peter, 21 Sep 2012, In: Journal of Biological Chemistry. 287, 39, p. 32913-32921Research output: Contribution to journal › Journal article › Research › peer-review
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Serum concentration and interaction properties of MBL/ficolin associated protein-1
Skjødt, Mikkel-Ole, Hummelshoj, T., Palarasah, Y., Hein, E., Munthe-fog, L., Koch, C., Skjodt, K. & Garred, Peter, 2011, In: Immunobiology. 216, 5, p. 625-632Research output: Contribution to journal › Journal article › Research › peer-review
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MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation
Skjødt, Mikkel-Ole, Palarasah, Y., Munthe-fog, L., Jie Ma, Y., Weiss, G., Skjodt, K., Koch, C. & Garred, Peter, 1 Nov 2010, In: Immunobiology. 215, 11, p. 921-931Research output: Contribution to journal › Journal article › Research › peer-review
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Two mannose-binding lectin homologues and an MBL-associated serine protease are expressed in the gut epithelia of the urochordate species Ciona intestinalis
Skjødt, Mikkel-Ole, Palarasah, Y., Rasmussen, K., Vitved, L., Salomonsen, J., Kliem, A., Hansen, S., Koch, C. & Skjødt, K., 2010, In: Developmental & Comparative Immunology. 34, 1, p. 59-68 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Defining the complement biomarker profile of C3 glomerulopathy
Zhang, Y., Nester, C. M., Martin, B., Skjødt, Mikkel-Ole, Meyer, N. C., Shao, D., Borsa, N., Palarasah, Y. & Smith, R. J. H., 2014, In: Clinical Journal of American Society of Nephrology. . 9, 11, p. 1876-82 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 45779926
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C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques
Research output: Contribution to journal › Journal article › Research › peer-review
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Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities
Research output: Contribution to journal › Journal article › Research › peer-review
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Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
Research output: Contribution to journal › Journal article › Research › peer-review
Published