Hans K Hasselbalch
Clinical Professor
Department of Clinical Medicine
Køgevej 7 - 13, 4000 Roskilde
Member of:
Internal Medicine: Haematology
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Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms
Andersen, Christen Bertel L, Grønbæk, Kirsten & Hasselbalch, Hans Carl, 1 Apr 2012, In: Leukemia Research. 36, 4, p. 485-487 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the blood eosinophil count with hematological malignancies and mortality
Andersen, Christen Bertel L, Siersma, Volkert Dirk, Hasselbalch, Hans Carl, Vestergaard, H., Mesa, R., Felding, P., Olivarius, Niels de Fine & Bjerrum, O. W., Mar 2015, In: American Journal of Hematology. 90, 3, p. 225-229 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Somatic mutations of the CREBBP and EP300 genes affect response to histone deacetylase inhibition in malignant DLBCL clones
Andersen, Christen Bertel L, Asmar, F., Klausen, T., Hasselbalch, Hans Carl & Grønbæk, K., 2012, In: Leukemia Research Reports. 2, 1, p. 1-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome
Andersen, Christen Bertel L, Nielsen, H. M., Sommer Kristensen, L., Helbo, A. S., Vikeså, J., Jønson, L., Nielsen, Finn Cilius, Hasselbalch, Hans Carl, Bjerrum, O. W., Punj, V. & Grønbæk, Kirsten, 2015, In: OncoTarget. 6, 38, p. 40588-97 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myeloproliferative Neoplasms in Danish Twins
Andersen, M. A., Bjerrum, O. W., Ranjan, A., Skov, V., Kruse, T. A., Thomassen, M., Skytthe, A., Hasselbalch, Hans Carl & Christensen, K., 2018, In: Acta Haematologica. 139, 3, p. 195-198 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-hoeyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T. A., Thomassen, M., Troelsen, J., Hasselbalch, Hans Carl & Ottesen, J. T., 2017, In: PLOS ONE. 12, 8, 18 p., e0183620.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-Related Macular Degeneration in Patients With Chronic Myeloproliferative Neoplasms
Bak, M., Sørensen, Torben Lykke, Flachs, E. M., Zwisler, A., Juel, K., Frederiksen, H. & Hasselbalch, Hans Carl, 2017, In: JAMA Ophthalmology. 135, 8, p. 835-843Research output: Contribution to journal › Journal article › Research › peer-review
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Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European leukemiaNet
Barbui, T., Barosi, G., Birgegard, G., Cervantes, F., Finazzi, G., Griesshammer, M., Harrison, C., Hasselbalch, H. C., Hehlmann, R., Hoffman, R., Kiladjian, J-J., Kröger, N., Mesa, R., McMullin, M. F., Pardanani, A., Passamonti, F., Vannucchi, A. M., Reiter, A., Silver, R. T., Verstovsek, S. & 1 others, , 20 Feb 2011, In: Journal of Clinical Oncology. 29, 6, p. 761-770 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Philadelphia chromosome-negative classical myeloproliferative neoplasms: revised management recommendations from European LeukemiaNet
Barbui, T., Tefferi, A., Vannucchi, A. M., Passamonti, F., Silver, R. T., Hoffman, R., Verstovsek, S., Mesa, R., Kiladjian, J-J., Hehlmann, R., Reiter, A., Cervantes, F., Harrison, C., Mc Mullin, M. F., Hasselbalch, H. C., Koschmieder, S., Marchetti, M., Bacigalupo, A., Finazzi, G., Kroeger, N. & 3 others, , 2018, In: Leukemia. 32, 5, p. 1057-1069Research output: Contribution to journal › Review › Research › peer-review
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Inflammatory functional iron deficiency common in myelofibrosis, contributes to anaemia and impairs quality of life. From the Nordic MPN study Group
Birgegard, G., Samuelsson, J., Ahlstrand, E., Ejerblad, E., Enevold, C., Ghanima, W., Hasselbalch, Hans Carl, Nielsen, Claus Henrik, Knutsen, H., Pedersen, Ole Birger Vesterager, Sørensen, A. & Andreasson, B., 2019, In: European Journal of Haematology. 102, 3, p. 235-240Research output: Contribution to journal › Journal article › Research › peer-review
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Association of the blood eosinophil count with end-organ symptoms
Bjerrum, O. W., Siersma, Volkert Dirk, Hasselbalch, Hans Carl, Lind, B. & Andersen, Christen Bertel L, 2019, In: Annals of Medicine and Surgery. 45, p. 11-18Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state
Bjørn, M. E., Andersen, Christen Bertel L, Jensen, M. K. & Hasselbalch, Hans Carl, 2014, In: European Journal of Haematology. 93, 3, p. 224-228 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis
Bjørn, M. E., Brimnes, M. K., Gudbrandsdottir, S., Andersen, C. L., Poulsen, Henrik Enghusen, Henriksen, T., Hasselbalch, Hans Carl & Nielsen, Claus Henrik, Oct 2019, In: Leukemia and Lymphoma. 60, 10, p. 2549-2557 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib
Bjørn, M. E. & Hasselbalch, Hans Carl, 2017, In: Expert Review of Hematology. 10, 5, p. 393-404Research output: Contribution to journal › Review › Research › peer-review
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Anxiety and depression in patients with Philadelphia-negative myeloproliferative neoplasms: a nationwide population-based survey in Denmark
Brochmann, N., Flachs, E. M., Christensen, A. I., Bak, M., Andersen, Christen Bertel L, Juel, K., Hasselbalch, Hans Carl, Zwisler, A. & Rottmann, N., 2019, In: Clinical Epidemiology. 11, p. 23-33Research output: Contribution to journal › Journal article › Research › peer-review
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A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents
Brochmann, N., Flachs, E. M., Christensen, A. I., Andersen, Christen Bertel L, Juel, K., Hasselbalch, Hans Carl & Zwisler, A., 2017, In: Clinical Epidemiology. 9, p. 141-150Research output: Contribution to journal › Journal article › Research › peer-review
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A new internet-based tool for reporting and analysing patient-reported outcomes and the feasibility of repeated data collection from patients with myeloproliferative neoplasms
Brochmann, N., Zwisler, A., Kjerholt, M., Flachs, E. M., Hasselbalch, Hans Carl & Andersen, Christen Bertel L, 2016, In: Quality of Life Research. 25, 4, p. 835-846 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression
Carnaz Simões, A. M., Holmström, M. O., Aehnlich, P., Rahbech, Anne, Radziwon-Balicka, A., Zamora, C., Wirenfeldt Klausen, T., Skov, V., Kjær, L., Ellervik, Christina, Fassi, Daniel El , Vidal, S., Hasselbalch, Hans Carl, Andersen, Mads Hald & thor Straten, P., 2022, In: Frontiers in Immunology. 13, 866610.Research output: Contribution to journal › Journal article › Research › peer-review
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Tobacco use in the Myeloproliferative neoplasms: symptom burden, patient opinions, and care
Christensen, S. F., Scherber, R. M., Mazza, G. L., Dueck, A. C., Brochmann, N., Andersen, Christen Bertel L, Hasselbalch, Hans Carl, Mesa, R. A. & Geyer, H. L., 2021, In: BMC Cancer. 21, 1, 13 p., 691.Research output: Contribution to journal › Journal article › Research › peer-review
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Healthcare resource utilization in patients with myeloproliferative neoplasms: A Danish nationwide matched cohort study
Christensen, S. F., Svingel, L. S., Kjaersgaard, A., Stenling, A., Darvalics, B., Paulsson, B., Andersen, Christen Bertel L, Christiansen, C. F., Stentoft, J., Starklint, J., Severinsen, M. T., Clausen, M. B., Hilsoe, M. H., Hasselbalch, Hans Carl, Frederiksen, H., Mikkelsen, E. M. & Bak, M., 2022, In: European Journal of Haematology. 109, 5, p. 526-541 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Early detection of myeloproliferative neoplasms in a Danish general population study
Cordua, S., Kjaer, L., Skov, V., Pallisgaard, N., Kefala, Maria, Gjerdrum, Lise Mette Rahbek, Hasselbalch, Hans Carl & Ellervik, Christina, 2021, In: Leukemia. 35, 9, p. 2706-2709 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population
Cordua, S., Kjaer, L., Skov, V., Pallisgaard, N., Hasselbalch, Hans Carl & Ellervik, Christina, 2019, In: Blood. 134, 5, p. 469-479Research output: Contribution to journal › Journal article › Research › peer-review
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JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation
Czech, J., Cordua, S., Weinbergerova, B., Baumeister, J., Crepcia, A., Han, L., Maié, T., Costa, I. G., Denecke, B., Maurer, A., Schubert, C., Feldberg, K., Gezer, D., Brümmendorf, T. H., Müller-newen, G., Mayer, J., Racil, Z., Kubesova, B., Knudsen, T., Sørensen, A. L. & 7 others, , 2019, In: Leukemia. 33, 4, p. 995-1010Research output: Contribution to journal › Journal article › Research › peer-review
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A novel integrated biomarker index for the assessment of hematological responses in MPNs during treatment with hydroxyurea and interferon-alpha2
Dam, M. J. B., Pedersen, R. K., Knudsen, T. A., Andersen, M., Ellervik, Christina, Larsen, Morten Kranker, Kjær, L., Skov, V., Hasselbalch, Hans Carl & Ottesen, J. T., 2023, In: Cancer Medicine. 12, 4, p. 4218-4226Research output: Contribution to journal › Journal article › Research › peer-review
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Data-driven analysis of the kinetics of the JAK2V617F allele burden and blood cell counts during hydroxyurea treatment of patients with polycythemia vera, essential thrombocythemia, and primary myelofibrosis
Dam, M. J. B., Pedersen, R. K., Knudsen, T. A., Andersen, M., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Ottesen, J. T., 2021, In: European Journal of Haematology. 107, 6, p. 624-633 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pronounced gut microbiota signatures in patients with JAK2V617F-positive essential thrombocythemia
Eickhardt-Dalbøge, C. S., Ingham, A. C., Nielsen, H. V., Fuursted, K., Stensvold, C. R., Andersen, L. O., Larsen, Morten Kranker, Kjær, L., Christensen, S. F., Knudsen, T. A., Skov, V., Ellervik, Christina, Olsen, L. R., Hasselbalch, Hans Carl, Elmer Christensen, J. J. & Nielsen, X. C., 2023, In: Microbiology Spectrum. 11, 5, 19 p., e0066223.Research output: Contribution to journal › Journal article › Research › peer-review
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JAK2V617F drives gut microbiota differences in patients with myeloproliferative neoplasms
Eickhardt-Dalbøge, C. S., Nielsen, H. V., Fuursted, K., Stensvold, C. R., Andersen, L. O., Lilje, B., Larsen, Morten Kranker, Kjær, L., Christensen, S. F., Knudsen, T. A., Skov, V., Sørensen, A. L., Ellervik, Christina, Olsen, L. R., Christensen, J. J. E., Nielsen, X. C., Hasselbalch, Hans Carl & Ingham, A. C., 2024, In: European Journal of Haematology. 112, 5, p. 776-787 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The gut microbiota in patients with polycythemia vera is distinct from that of healthy controls and varies by treatment
Eickhardt-dalbøge, C. S., Ingham, A. C., Andersen, L. O., Nielsen, H. V., Fuursted, K., Stensvold, C. R., Larsen, M. K., Kjær, L., Christensen, S. F., Knudsen, T. A., Skov, V., Ellervik, C., Olsen, L. R., Hasselbalch, Hans Carl, Nielsen, X. C. & Christensen, J. J. E., 2023, In: Blood advances. 7, 13, p. 3326-3337 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic inflammation and autoimmunity as risk factors for the development of chronic myelomonocytic leukemia?
Elbæk, M. V., Sørensen, A. L. & Hasselbalch, Hans Carl, 2 Aug 2016, In: Leukemia and Lymphoma. 57, 8, p. 1793-1799 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cardiovascular disease in chronic myelomonocytic leukemia: do monocytosis and chronic inflammation predispose to accelerated atherosclerosis?
Elbæk, M. V., Sørensen, A. L. & Hasselbalch, Hans Carl, 2019, In: Annals of Hematology. 98, 1, p. 101-109Research output: Contribution to journal › Journal article › Research › peer-review
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A retrospective analysis of the impact of treatments and blood counts on survival and the risk of vascular events during the course of polycythaemia vera
Enblom-Larsson, A., Girodon, F., Bak, M., Hersby, D., Jooste, V., Hasselbalch, Hans Carl, Johansson, P. & Andreasson, B., 2017, In: British Journal of Haematology. 177, 5, p. 800-805Research output: Contribution to journal › Journal article › Research › peer-review
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Response to pegylated interferon in a COVID-19–positive elderly woman with primary myelofibrosis treated with ruxolitinib
Frankel, A. E., Reddy, R., DeSuza, K. R., Deeb, K., Carlin, A. F., Smith, D., Xie, Y., Naik, E., Silver, R. T. & Hasselbalch, Hans Carl, 2021, In: Clinical Case Reports. 9, 4, p. 2228-2235 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to pegylated interferon in a COVID-19 positive male with metastatic jejunal neuroendocrine tumor treated with everolimus
Frankel, A. E., Yip, W. C., Naik, E. & Hasselbalch, Hans Carl, 2021, In: Clinical Case Reports. 9, 6, e04218.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic myeloproliferative neoplasms and subsequent cancer risk: A Danish population-based cohort study
Frederiksen, H., Farkas, D. K., Christiansen, C. F., Sørensen, H. T. & Hasselbalch, Hans Carl, 15 Dec 2011, In: Blood. 118, 25, p. 6515-6520 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vascular diseases in patients with chronic myeloproliferative neoplasms: Impact of comorbidity
Frederiksen, H., Szépligeti, S., Bak, M., Ghanima, W., Hasselbalch, Hans Carl & Christiansen, C. F., 2019, In: Clinical Epidemiology. 2019, 11, p. 955-967Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia
Garabet, L., Ghanima, W., Monceyron Jonassen, C., Skov, V., Holst, R., Mowinckel, M., Hasselbalch, Hans Carl, A. Kruse, T., Thomassen, M., Liebman, H., Bussel, J. B. & Sandset, P. M., 2019, In: Platelets. 30, 2, p. 206-212Research output: Contribution to journal › Journal article › Research › peer-review
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Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents
Ghanima, W., Bussel, J. B., Junker, P., Hasselbalch, Hans Carl, Gudbrandsdottir, S., Boiocchi, L., Geyer, J. T., Orazi, A. & Feng, X., 1 Oct 2011, In: British Journal of Haematology. 155, 2, p. 248-255 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine
Gigoux, M., Holmström, M. O., Zappasodi, R., Park, J. J., Pourpe, S., Bozkus, C. C., Mangarin, L. M. B., Redmond, D., Verma, S., Schad, S., George, M. M., Venkatesh, D., Ghosh, A., Hoyos, D., Molvi, Z., Kamaz, B., Marneth, A. E., Duke, W., Leventhal, M. J., Jan, M. & 23 others, , 2022, In: Science Translational Medicine. 14, 649, eaba4380.Research output: Contribution to journal › Journal article › Research › peer-review
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Event-free survival in patients with polycythemia vera treated with ropeginterferon alfa-2b versus best available treatment
the PROUD-PV Study Group, T. P. S. G., 2023, In: Leukemia. 37, 10, p. 2129-2132 4 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study
Gisslinger, H., Klade, C., Georgiev, P., Krochmalczyk, D., Gercheva-Kyuchukova, L., Egyed, M., Rossiev, V., Dulicek, P., Illes, A., Pylypenko, H., Sivcheva, L., Mayer, J., Yablokova, V., Krejcy, K., Grohmann-Izay, B., Hasselbalch, H. C., Kralovics, R., Kiladjian, J. J., Bauer, F., Berbec, N. & 41 others, , 2020, In: The Lancet Haematology. 7, 3, p. e196-e208 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ropeginterferon Alfa-2b: Efficacy and Safety in Different Age Groups
Gisslinger, H., Klade, C., Georgiev, P., Krochmalczyk, D., Gercheva-kyuchukova, L., Egyed, M., Rossiev, V., Dulicek, P., Illes, A., Pylypenko, H., Sivcheva, L., Mayer, J., Yablokova, V., Krejcy, K., Hasselbalch, Hans Carl, Kralovics, R. & Kiladjian, J., 2020, In: HemaSphere. 4, 6, 4 p., e485.Research output: Contribution to journal › Journal article › Research › peer-review
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Serum levels of IL-4, IL-13 and IL-33 in patients with age-related macular degeneration and myeloproliferative neoplasms
Gotfredsen, K., Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 11 Mar 2023, In: Scientific Reports. 13, 1, p. 4077 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An arginase1- and PD-L1-derived peptide-based vaccine for myeloproliferative neoplasms: A first-in-man clinical trial
Grauslund, J. H., Holmström, M. O., Martinenaite, E., Lisle, T. L., Glöckner, H. J., Fassi, Daniel El , Klausen, U., Mortensen, R. E. J., Jørgensen, N., Kjær, L., Skov, V., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2023, In: Frontiers in Immunology. 14, 14 p., 1117466.Research output: Contribution to journal › Journal article › Research › peer-review
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Classification and Personalized Prognosis in Myeloproliferative Neoplasms
Grinfeld, J., Nangalia, J., Baxter, E. J., Wedge, D. C., Angelopoulos, N., Cantrill, R., Godfrey, A. L., Papaemmanuil, E., Gundem, G., MacLean, C., Cook, J., O'Neil, L., O'Meara, S., Teague, J. W., Butler, A. P., Massie, C. E., Williams, N., Nice, F. L., Andersen, C. L., Hasselbalch, H. C. & 7 others, , 2018, In: The New England Journal of Medicine. 379, 15, p. 1416-1430Research output: Contribution to journal › Journal article › Research › peer-review
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Thrombopoietin-receptor agonists in haematological disorders: The Danish experience
Gudbrandsdottir, S., Hasselbalch, Hans Carl & Frederiksen, H., 1 Sep 2012, In: Platelets. 23, 6, p. 423-429 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of rituximab and dexamethasone on regulatory and proinflammatory B-cell subsets in patients with primary immune thrombocytopenia
Gudbrandsdottir, S., Brimnes, M., Køllgaard, T., Hasselbalch, Hans Carl & Nielsen, C. H., 2018, In: European Journal of Haematology. 100, 1, p. 45-52Research output: Contribution to journal › Journal article › Research › peer-review
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Safety and efficacy of the combination of sonidegib and ruxolitinib in myelofibrosis: A phase 1b/2 dose-finding study
Gupta, V., Wolleschak, D., Hasselbalch, Hans Carl, Vannucchi, A. M., Koschmieder, S., Cervantes, F., Li, Y., Dong, T., Wroclawska, M., Bharathy, S. & Harrison, C., 2020, In: Blood advances. 4, 13, p. 3063-3071 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms
Handlos Grauslund, J., Holmström, M. O., Jørgensen, N. G., Klausen, U., Weis-Banke, S. E., El Fassi, D., Schöllkopf, C., Clausen, M. B., Gjerdrum, L. M. R., Breinholt, M. F., Kjeldsen, J. W., Hansen, M., Koschmieder, S., Chatain, N., Novotny, G. W., Petersen, J., Kjær, L., Skov, V., Met, Ö., Svane, I. M. & 2 others, , 26 Feb 2021, In: Frontiers in Oncology. 11, 17 p., 637420.Research output: Contribution to journal › Journal article › Research › peer-review
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Second malignancies in hydroxyurea and interferon-treated Philadelphia-negative myeloproliferative neoplasms
Hansen, I. O., Sørensen, A. L. & Hasselbalch, Hans Carl, 2017, In: European Journal of Haematology. 98, 1, p. 75-84Research output: Contribution to journal › Journal article › Research › peer-review
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Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre-diagnostic period
Hansen, Jakob Werner, Sandholdt, H., Siersma, Volkert Dirk, mxz703, mxz703, Holmberg, S., Bjerrum, O. W., Hasselbalch, Hans Carl, Olivarius, Niels de Fine, Grønbæk, Kirsten & Andersen, Christen Bertel L, Jul 2017, In: American Journal of Hematology. 92, 7, p. E130-E132 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Sonographic measurement of the thymus in infants
Hasselbalch, Hans Carl, Nielsen, Michael Bachmann, Jeppesen, Dorthe Lisbeth, Pedersen, J. F. & Karkov, J., 1996, In: European Radiology. 6, 5, p. 700-703 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms
Hasselbalch, Hans Carl, 1 Dec 2011, In: Expert Review of Hematology. 4, 6, p. 637-655 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interferon-alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Status and perspectives
Hasselbalch, Hans Carl, Larsen, T. S., Riley, C. H., Jensen, M. K. & Kiladjian, J., 1 Jan 2011, In: Current Drug Targets. 12, 3, p. 392-419 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interferon alfa in the treatment of philadelphia-negative chronic myeloproliferative neoplasms
Hasselbalch, Hans Carl, Kiladjian, J. & Silver, R. T., 20 Jun 2011, In: Journal of Clinical Oncology. 29, 18Research output: Contribution to journal › Journal article › Research › peer-review
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Interferon alpha2 in the treatment of hematological malignancies. status and perspectives
Hasselbalch, Hans Carl, 1 Jan 2011, In: Current Drug Targets. 12, 3, p. 387-391 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives
Hasselbalch, Hans Carl, Skov, V., Kjær, L., Larsen, Morten Kranker, Knudsen, T. A., Lucijanić, M. & Kusec, R., 2022, In: Cancers. 14, 22, 5495.Research output: Contribution to journal › Journal article › Research › peer-review
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New Perspectives of Interferon-alpha2 and Inflammation in Treating Philadelphia-negative Chronic Myeloproliferative Neoplasms
Hasselbalch, Hans Carl & Silver, R. T., 2021, In: HemaSphere. 5, 12, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer's disease: evidences and perspectives
Hasselbalch, Hans Carl, Skov, V., Kjær, L., Sørensen, Torben Lykke, Ellervik, Christina & Wienecke, Troels, 2020, In: Journal of Neuroinflammation. 17, 13 p., 248.Research output: Contribution to journal › Review › Research › peer-review
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Rationaler for behandling med januskinase 1/2-hæmning af svært syge patienter med COVID-19-pneumoni
Hasselbalch, Hans Carl, Poulsen, Anne, Skov, V., Kjær, L., Nielsen, C. H. & Poulsen, T. D., 2020, In: Ugeskrift for Laeger. 182, 25, 9 p., V04200234.Research output: Contribution to journal › Review › Research › peer-review
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Time for revival of the red blood cell count and red cell mass in the differential diagnosis between essential thrombocythemia and polycythemia vera?
Hasselbalch, Hans Carl, 2019, In: Haematologica. 104, 11, p. 2119-2125Research output: Contribution to journal › Editorial › Research
- Published
Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?
Hasselbalch, Hans Carl & Holmström, M. O., 2019, In: Seminars in Immunopathology. 41, 1, p. 5-19Research output: Contribution to journal › Review › Research › peer-review
- Published
Forhøjede blodcelletal og vaskulær sygdom med de myeloproliferative neoplasier som modelsygdomme
Hasselbalch, Hans Carl, Knudsen, T. A., Sørensen, A. L., Christensen, S. F., Larsen, Morten Kranker, Bak, M., El Fassi, D., Cordua, S., Brabrand, M., Thomsen, G., Stentoft, J., Starklint, J., Ellervik, Christina, Wienecke, Troels, Bruun, Niels Eske, Eickhardt-Dalbøge, C. E., Kjær, L. & Skov, V., 18 Oct 2021, In: Ugeskrift for Laeger. 183, 42, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms
Hasselbalch, Hans Carl, Elvers, M. & Schafer, A. I., 2021, In: Blood. 137, 16, p. 2152-2160 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Molecular profiling as a novel tool to predict response to interferon-α2 in MPNs: The proof of concept in early myelofibrosis
Hasselbalch, Hans Carl, 2017, In: Cancer. 123, 14, p. 2600-2603Research output: Contribution to journal › Editorial › Research
- Published
CHIP-JAK2V617F, chronic inflammation, abnormal megakaryocyte morphology, organ failure, and multimorbidties
Hasselbalch, Hans Carl, Kristiansen, M. H., Kjær, L., Skov, V., Larsen, Morten Kranker, Ellervik, Christina & Wienecke, Troels, 2024, In: Blood advances. 8, 3, p. 681-682 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms
Hasselbalch, Hans Carl, Junker, P., Skov, V., Kjær, L., Knudsen, T. A., Larsen, Morten Kranker, Holmström, M. O., Andersen, Mads Hald, Jensen, C., Karsdal, M. A. & Willumsen, N., 2023, In: Cancers. 15, 17, 47 p., 4323.Research output: Contribution to journal › Review › Research › peer-review
- Published
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?
Hasselbalch, Hans Carl, Feb 2013, In: Leukemia Research. 37, 2, p. 214-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of cytokines in the initiation and progression of myelofibrosis
Hasselbalch, Hans Carl, Apr 2013, In: Cytokine & Growth Factor Reviews. 24, 2, p. 133-45 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?
Hasselbalch, Hans Carl, 5 Apr 2012, In: Blood. 119, 14, p. 3219-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinguishing myelofibrosis from polycythemia vera and essential thrombocythemia: The utility of enumerating circulating stem cells with aberrant hMICL expression by flow cytometry
Herborg, L. L., Nederby, L., Hasselbalch, Hans Carl, Aggerholm, A. & Roug, A. S., 2018, In: International Journal of Laboratory Hematology. 40, 3, p. 320-325Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The calreticulin (CALR) exon 9 mutations are promising targets for cancer immune therapy
Holmstrom, M. O., Martinenaite, E., Ahmad, S. M., Met, Özcan, Friese, C., Kjaer, L., Riley, C. H., Straten, P. T., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 1 Feb 2018, In: Leukemia. 32, 2, p. 429-437Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The JAK2V617F and CALR exon 9 mutations are shared immunogenic neoantigens in hematological malignancy
Holmstrom, M. O., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: OncoImmunology. 6, 11, 3 p., e1358334.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spontaneous T-cell responses against the immune check point programmed-death-ligand 1 (PD-L1) in patients with chronic myeloproliferative neoplasms correlate with disease stage and clinical response
Holmström, M. O., Riley, C. H., Skov, V., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2018, In: OncoImmunology. 7, 6, e1433521.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow
Holmström, M. O., Andersen, M., Traynor, S., Ahmad, S. M., Lisle, T. L., Handlos Grauslund, J., Skov, V., Kjær, L., Ottesen, J. T., Gjerstorff, M. F., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2023, In: Frontiers in Immunology. 14, 14 p., 1240678.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancerimmunterapi til behandling af hæmatologisk cancer
Holmström, M. O., Klausen, U., Jørgensen, N. G., Holmberg, S., Grauslund, J., Met, Ö., Svane, Inge Marie, Pedersen, Lars Møller, Knudsen, L. M., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2019, In: Ugeskrift for Laeger. 181, 10, 5 p., V06180421.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
Holmström, M. O., Hjortso, M. D., Ahmad, S. M., Met, Özcan, Martinenaite, E., Riley, C., Straten, P., Svane, Inge Marie, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2017, In: Leukemia. 31, p. 495-498Research output: Contribution to journal › Letter › Research › peer-review
- Published
Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer
Holmström, M. O., Cordua, S., Skov, V., Kjær, L., Pallisgaard, N., Ellervik, Christina, Hasselbalch, Hans Carl & Andersen, Mads Hald, 2020, In: Cancer Immunology, Immunotherapy. 69, p. 315–324Research output: Contribution to journal › Review › Research › peer-review
- Published
Terapeutisk cancervaccination mod hæmatologisk cancer
Holmström, M. O., Grauslund, J. H., Dahlager-Jørgensen, N. G., Klausen, U., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2019, In: Ugeskrift for Laeger. 181, 20A, 5 p., V04190233.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer immune therapy for Philadelphia chromosome-negative chronic myeloproliferative neoplasms
Holmström, M. O., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2020, In: Cancers. 12, 7, p. 1-21 21 p., 1763.Research output: Contribution to journal › Review › Research › peer-review
- Published
Progression of JAK2-mutant polycythemia vera to CALR-mutant myelofibrosis severely impacts on disease phenotype and response to therapy
Holmström, M. O., Novotny, G. W., Petersen, J., Aaboe-Jørgensen, M., Hasselbalch, Hans Carl, Andersen, Mads Hald, Nielsen, S. L., Fassi, Daniel El & Schöllkopf, C., 2019, In: Leukemia and Lymphoma. 60, 13, p. 3296-3299Research output: Contribution to journal › Letter › Research › peer-review
- Published
Cancer immune therapy for myeloid malignancies: present and future
Holmström, M. O. & Hasselbalch, Hans Carl, 2019, In: Seminars in Immunopathology. 41, 1, p. 97-109Research output: Contribution to journal › Review › Research › peer-review
- Published
Neo-antigen specific memory T-cell responses in healthy individuals
Holmström, M. O., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2019, In: OncoImmunology. 8, 7, 2 p., 1599640.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Smoking, blood cells and myeloproliferative neoplasms: meta-analysis and Mendelian randomization of 2·3 million people
Jayasuriya, N. A., Kjaergaard, A. D., Pedersen, K. M., Sørensen, A. L., Bak, M., Larsen, M. K., Nordestgaard, Børge, Bojesen, Stig Egil, Çolak, Y., Skov, V., Kjaer, L., Tolstrup, J. S., Hasselbalch, Hans Carl & Ellervik, Christina, Apr 2020, In: British Journal of Haematology. 189, 2, p. 323-334 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation
Jørgensen, M. A., Holmström, M. O., Martinenaite, E., Riley, C. H., Hasselbalch, Hans Carl & Andersen, Mads Hald, 2018, In: OncoImmunology. 7, 9, 8 p., e1468957.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term outcomes of polycythemia vera patients treated with ropeginterferon Alfa-2b
PROUD-PV Study Grp, P. S. G., May 2022, In: Leukemia. 36, 5, p. 1408-1411 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes
Kjaer, L., Holmström, M. O., Cordua, S., Andersen, Mads Hald, Svane, Inge Marie, Thomassen, M., Kruse, T. A., Pallisgaard, N., Skov, V. & Hasselbalch, Hans Carl, Apr 2018, In: Leukemia and Lymphoma. 59, 4, p. 973-977 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variant‐specific discrepancy when quantitating BCR‐ABL1 e13a2 and e14a2 transcripts using the Europe Against Cancer qPCR assay
Kjaer, L., Skov, V., Andersen, M. T., Aggerholm, A., Clair, P., Gniot, M., Søby, K., Udby, L., Dorff, Mikkel Helleberg, Hasselbalch, Hans Carl & Pallisgaard, N., 2019, In: European Journal of Haematology. 103, 1, p. 26-34Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A highly sensitive quantitative real-time pcr assay for determination of mutant jak2 exon 12 allele burden
Kjær, L., Riley, C. H., Westman, M., Høgdall, Estrid Vilma Solyom, Bjerrum, O. W. & Hasselbalch, Hans Carl, 5 Mar 2012, In: PLOS ONE. 7, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis
Kjær, L., Skov, V., Larsen, Morten Kranker, Boklund, T. I., Andersen, M., Kefala, Maria, Knudsen, T. A., Schjellerup Eickhardt-Dalbøge, C., Stiehl, T., Gudmand-Høyer, J., Snyder, J., Holmström, M., Andersen, M. H., Ottesen, J. T., Ellervik, Christina & Hasselbalch, Hans Carl, 2023, In: Frontiers in Oncology. 13, 8 p., 1176173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic profiling of a randomized trial of interferon-a vs hydroxyurea in MPN reveals mutation-specific responses
Knudsen, T. A., Skov, V., Stevenson, K., Werner, L., Duke, W., Laurore, C., Gibson, C. J., Nag, A., Thorner, A. R., Wollison, B., Hansen, D. L., Ellervik, C., Fassi, D. E., de Stricker, K., Ocias, L. F., Brabrand, M., Bjerrum, O. W., Overgaard, U. M., Frederiksen, M., Kristensen, T. K. & 12 others, , 2022, In: Blood advances. 6, 7, p. 2107-2119 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study
Kristiansen, M. H., Kjær, L., Skov, V., Larsen, Morten Kranker, Ellervik, Christina, Hasselbalch, Hans Carl & Wienecke, Troels, 2023, In: Blood advances. 7, 19, p. 5825-5834 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up
Larsen, Morten Kranker, Skov, V., Kjær, L., Møller-Palacino, N. A., Pedersen, R. K., Andersen, M., Ottesen, J. T., Cordua, S., Poulsen, Henrik Enghusen, Dahl, Morten, Knudsen, T. A., Eickhardt-Dalbøge, C. S., Koschmieder, S., Pedersen, K. M., Çolak, Y., Bojesen, Stig Egil, Nordestgaard, Børge, Stiehl, T., Hasselbalch, Hans Carl & Ellervik, Christina, 2022, In: European Journal of Haematology. 109, 5, p. 576-585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms-a Danish longitudinal study
Larsen, Morten Kranker, Skov, V., Kjær, L., Eickhardt-Dalbøge, C. S., Knudsen, T. A., Kristiansen, M. H., Sørensen, A. L., Wienecke, Troels, Andersen, M., Ottesen, J. T., Gudmand-Høyer, J., Snyder, J. A., Andersen, M. P., Torp-Pedersen, Christian, Poulsen, Henrik Enghusen, Stiehl, T., Hasselbalch, Hans Carl & Ellervik, Christina, 2024, In: Blood Cancer Journal. 14, 1, 12 p., 28.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence
Lataillade, J. J., Pierre-Louis, O., Uzan, G., Jasmin, C., Martyre, M. C., Bousse-Kerdiles, M. C. L. & Hasselbalch, Hans Carl, 2008, In: Blood. 112, 8, p. 3026-3035 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms
Liisborg, C., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2020, In: Cancers. 12, 3, 14 p., 573.Research output: Contribution to journal › Review › Research › peer-review
- Published
Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation
Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2022, In: EClinicalMedicine. 43, 101248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers
Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, Jun 2022, In: PLoS ONE. 17, 6, 16 p., e0269960.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Retinal drusen in patients with chronic myeloproliferative blood cancers are associated with an increased proportion of senescent T cells and signs of an aging immune system
Liisborg, C., Skov, V., Kjær, L., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2021, In: Aging. 13, 24, p. 25763—25777Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patients with myeloproliferative neoplasms and high levels of systemic inflammation develop age-related macular degeneration
Liisborg, C., Krogh Nielsen, M., Hasselbalch, Hans Carl & Sørensen, Torben Lykke, 2020, In: EClinicalMedicine. 26, 8 p., 100526.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel immunohistochemical sequential multi-labelling and erasing technique enables epitope characterization of bone marrow pericytes in primary myelofibrosis
Madelung, A., Bzorek, M., Bondo, H., Zetterberg, E., Bjerrum, O. W., Hasselbalch, Hans Carl, Scheding, S. & Ralfkiaer, E., 2012, In: Histopathology. 60: 554 – 660.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience
Madelung, A. B., Bondo, H., Stamp, I., Løvgreen, P., Nielsen, S. L., Falensteen, A., Knudsen, H., Svendsen, K. D., Lange, Theis, Ralfkiaer, E., Nielsen, K., Hasselbalch, Hans Carl & Thiele, J., Sep 2015, In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 123, 9, p. 787-92 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon alpha-2 treatment reduces circulating neutrophil extracellular trap levels in myeloproliferative neoplasms
Massarenti, Laura, Knudsen, T. A., Enevold, Christian, Skov, V., Kjær, L., Larsen, M. K., Larsen, T. S., Hansen, D. L., Hasselbalch, Hans Carl & Nielsen, Claus Henrik, 2023, In: British Journal of Haematology. 202, 2, p. 318-327 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Methylation age as a correlate for allele burden, disease status, and clinical response in myeloproliferative neoplasm patients treated with vorinostat
McPherson, S., Greenfield, G., Andersen, Christen Bertel L, Grinfeld, J., Hasselbalch, Hans Carl, Nangalia, J., Mills, K. I. & McMullin, M. F., 2019, In: Experimental Hematology. 79, p. 26-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis
Mikkelsen, Stine Ulrik, Kjaer, L., Bjørn, M. E., Knudsen, T. A., Sørensen, A. L., Andersen, Christen Bertel L, Bjerrum, O. W., Brochmann, N., Fassi, Daniel El , Kruse, T. A., Larsen, T. S., Mourits-Andersen, H. T., Nielsen, Claus Henrik, Pallisgaard, N., Thomassen, M., Skov, V. & Hasselbalch, Hans Carl, Aug 2018, In: Cancer Medicine. 7, 8, p. 3571-3581 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations
Myrtue Nielsen, H., Andersen, Christen Bertel L, Westman, M., Sommer Kristensen, L., Asmar, F., Arvid Kruse, T., Thomassen, M., Stauffer Larsen, T., Skov, V., Lotte Hansen, L., Weis Bjerrum, O., Hasselbalch, Hans Carl, Punj, V. & Grønbæk, Kirsten, 2017, In: Scientific Reports. 7, 11 p., 6774.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bridging blood cancers and inflammation: The reduced Cancitis model
Ottesen, J. T., Pedersen, R. K., Sajid, Z., Gudmand-hoeyer, J., Bangsgaard, K. O., Skov, V., Kjær, L., Knudsen, T. A., Pallisgaard, N., Hasselbalch, Hans Carl & Andersen, M., 2019, In: Journal of Theoretical Biology. 465, p. 90-108Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Age-related prevalence and clinical significance of neutropenia - isolated or combined with other cytopenias: Real world data from 373 820 primary care individuals
Palmblad, J., Siersma, Volkert Dirk, Lind, B., Bjerrum, O. W., Hasselbalch, Hans Carl & Andersen, Christen Bertel L, 2020, In: American Journal of Hematology. 95, 5, p. 521-528 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study
Pedersen, K. M., Bak, M., Sørensen, A. L., Zwisler, A., Ellervik, Christina, Larsen, M. K., Hasselbalch, Hans Carl & Tolstrup, J. S., 2018, In: Cancer Medicine. 7, 11, p. 5796-5802 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effectiveness of exercise-based rehabilitation to patients with myeloproliferative neoplasms: An explorative study
Pedersen, K. M., Zangger, G., Brochmann, N., Grønfeldt, B. M., Zwisler, A. D., Hasselbalch, Hans Carl & Tang, L. H., 2018, In: European Journal of Cancer Care. 27, 5, 10 p., e12865.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study
Pedersen, K. M., Çolak, Y., Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2020, In: EClinicalMedicine. 21, 100280.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Smoking and Increased White and Red Blood Cells
Pedersen, K. M., Çolak, Y., Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2019, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 5, p. 965-977 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tocilizumab and soluble interleukin-6 receptor in JAK2V617F somatic mutation and myeloproliferative neoplasm
Pedersen, K. M., Çolak, Y., Hasselbalch, Hans Carl, Bojesen, Stig Egil & Nordestgaard, Børge, 2020, In: EClinicalMedicine. 22, 100337.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Two-fold risk of pneumonia and respiratory mortality in individuals with myeloproliferative neoplasm: A population-based cohort study
Pedersen, K. M., Çolak, Y., Hasselbalch, Hans Carl, Ellervik, Christina, Nordestgaard, Børge & Bojesen, Stig Egil, 2020, In: EClinicalMedicine. 21, 100295.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms
Pedersen, R. K., Andersen, M., Knudsen, T. A., Sajid, Z., Gudmand-Hoeyer, J., Dam, M. J. B., Skov, V., Kjær, L., Ellervik, Christina, Larsen, T. S., Hansen, D., Pallisgaard, N., Hasselbalch, Hans Carl & Ottesen, J. T., 2020, In: Cancer Medicine. 9, 6, p. 2039-2051Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increase in circulating CD4CD25Foxp3 T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α
Riley, C. H., Morten Krogh, J., Brimnes, M. K., Straten, P. T., Svane, Inge Marie, Hasselbalch, Hans Carl & Bjerrum, O. W., 25 Aug 2011, In: Blood. 118, 8, p. 2170-2173 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera
Riley, C. H., Brimnes, M. K., Hansen, M., Jensen, M. K., Hasselbalch, Hans Carl, Kjaer, L., Straten, P. T. & Svane, Inge Marie, 2016, In: European Journal of Haematology. 97, 1, p. 83-92 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis
Hasselbalch, Hans Carl, Skov, V., Larsen, T. S., Thomassen, M., Riley, C. H., Jensen, M. K., Bjerrum, O. W. & Kruse, T. A., 2011, In: Leukemia Research. 35, 10, p. 1330-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis
Silver, R. T., Kiladjian, J. & Hasselbalch, Hans Carl, Feb 2013, In: Expert Review of Hematology. 6, 1, p. 49-58 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimal therapy for polycythemia vera and essential thrombocythemia: Preferred use of interferon therapy based on phase 2 trials
Silver, R. T. & Hasselbalch, Hans Carl, 2016, In: Hematology. 21, 7, p. 387-391 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: Identification of deregulated genes of significance for inflammation and immune surveillance
Skov, V., Thomassen, M., Kruse, T. A., Larsen, T. S., Riley, C. H., Jensen, M. S. K., Bjerrum, O. W. & Hasselbalch, Hans Carl, 1 Nov 2012, In: Leukemia Research. 36, 11, p. 1387-1392 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis
Skov, V., Thomassen, M., Kruse, T. A., Riley, C. H., Jensen, M. K., Bjerrum, O. W., Hasselbalch, Hans Carl & Larsen, T. S., 1 Sep 2012, In: Experimental Hematology. 40, 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms
Skov, V., Thomassen, M., Kjær, L., Ellervik, Christina, Larsen, Morten Kranker, Knudsen, T. A., Kruse, T. A. & Hasselbalch, Hans Carl, 2022, In: PLoS ONE. 17, 6 , e0270669.Research output: Contribution to journal › Journal article › Research › peer-review
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Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms
Solli, C. N., Chamat-Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, Christina, Fuchs, A., Sigvardsen, P. E., Kühl, J. T., Kofoed, Klaus Fuglsang, Nordestgaard, Børge, Hasselbalch, Hans Carl & Bruun, Niels Eske, 2022, In: International Journal of Cardiology. 364, p. 112-118 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High JAK2V617F variant allele frequency is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms
Solli, C. N., Chamat-Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, Christina, Hasselbalch, Hans Carl & Bruun, Niels Eske, 2023, In: European Journal of Haematology. 111, 3, p. 400-406 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Statin treatment, oxidative stress and inflammation in a Danish population
Sørensen, A. L., Hasselbalch, Hans Carl, Nielsen, C. H., Poulsen, Henrik Enghusen & Ellervik, C., 2019, In: Redox Biology. 21, 7 p., 101088.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study
Sørensen, A. L., Hasselbalch, Hans Carl, Bjørn, M. E., Nielsen, C. H., Cordua, S., Skov, V., Kjær, L., Poulsen, Henrik Enghusen & Ellervik, Christina, 2021, In: Redox Biology. 41, 101895.Research output: Contribution to journal › Journal article › Research › peer-review
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Smoking impairs molecular response, and reduces overall survival in patients with chronic myeloproliferative neoplasms: A retrospective cohort study
Sørensen, A. L., Knudsen, T. A., Skov, V., Kjær, L., Holm, N., Ellervik, Christina & Hasselbalch, Hans Carl, 2021, In: British Journal of Haematology. 193, 1, p. 83-92Research output: Contribution to journal › Journal article › Research › peer-review
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Antecedent cardiovascular disease and autoimmunity in Philadelphia-negative chronic myeloproliferative neoplasms
Sørensen, A. L. & Hasselbalch, Hans Carl, 1 Feb 2016, In: Leukemia Research. 41, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations between Fatigue, Physical Activity, and QoL in Patients with Myeloproliferative Neoplasms
Tolstrup Larsen, R., Tang, L. H., Brochmann, N., Meulengracht Flachs, E., Illemann Christensen, A., Hasselbalch, Hans Carl & Zwisler, A., 2018, In: European Journal of Haematology. 100, 6, p. 550-559 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated white blood cell counts in ischemic stroke patients are associated with increased mortality and new vascular events
Vo, T. P., Kristiansen, M. H., Hasselbalch, Hans Carl & Wienecke, Troels, 2023, In: Frontiers in Neurology. 14, 8 p., 1232557.Research output: Contribution to journal › Journal article › Research › peer-review
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Whole Blood Gene Expression Profiling in patients undergoing colon cancer surgery identifies differential expression of genes involved in immune surveillance, inflammation and carcinogenesis
Watt, S. K., Hasselbalch, Hans Carl, Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M. & Gögenur, Ismail, 2018, In: Surgical Oncology. 27, 2, p. 208-215 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased oxidative stress with substantial dysregulation of genes related to oxidative stress and DNA repair after laparoscopic colon cancer surgery
Watt, S. K., Hasselbalch, Hans Carl, Skov, V., Kjær, L., Thomassen, M., Kruse, T. A., Burton, M., Poulsen, Henrik Enghusen & Gögenur, Ismail, 2020, In: Surgical Oncology. 35, p. 71-78 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-invasive imaging of retinal blood flow in myeloproliferative neoplasms
Willerslev, A., Hansen, M. M., Klefter, O. N., Bjerrum, O. W., Hasselbalch, Hans Carl, Clemmensen, S. N., Larsen, Michael & Munch, I. C., Mar 2017, In: Acta Ophthalmologica. 95, 2, p. 146–152Research output: Contribution to journal › Journal article › Research › peer-review
ID: 2849472
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A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents
Research output: Contribution to journal › Journal article › Research › peer-review
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154
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Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations
Research output: Contribution to journal › Journal article › Research › peer-review
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137
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Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
Research output: Contribution to journal › Journal article › Research › peer-review
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