Michal Tomasz Marzec
Guest researcher
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
- 2005
- Published
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
Marzec, Michal Tomasz, Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Ødum, Niels & Wasik, M. A., 2005, In: Laboratory Investigation. 85, 12, p. 1544-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum.
Wlodarski, P., Kasprzycka, M., Liu, X., Marzec, Michal Tomasz, Robertson, E. S., Slupianek, A. & Wasik, M. A., 2005, In: Cancer Research. 65, 17, p. 7800-7808 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Zhang, Q., Wang, H. Y., Marzec, Michal Tomasz, Raghunath, P. N., Nagasawa, T. & Wasik, M. A., 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 19, p. 6948-6953 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
Peroxisome Proliferator-Activated Receptor γ Promotes Lymphocyte Survival through Its Actions on Cellular Metabolic Activities.
Jo, S., Yang, C., Miao, Q., Marzec, Michal Tomasz, Wasik, M. A., Lu, P. & Wang, Y. L., 2006, In: Journal of Immunology. 177, 6, p. 3737-3745 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.
Kasprzycka, M., Majewski, M., Wang, Z., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, Michal Tomasz, Gimotty, P., Crompton, M. R. & Wasik, M. A., 2006, In: American Journal of Pathology. 168, 5, p. 1631-1641 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
Kasprzycka, M., Marzec, Michal Tomasz, Liu, X., Zhang, Q. & Wasik, M. A., 27 Jun 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 26, p. 9964-9969Research output: Contribution to journal › Journal article › Research › peer-review
Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity
Marzec, Michal Tomasz, Kasprzycka, M., Lai, R., Gladden, A. B., Wlodarski, P., Tomczak, E., Nowell, P., DePrimo, S. E., Sadis, S., Eck, S., Schuster, S. J., Diehl, J. A. & Wasik, M. A., 1 Sep 2006, In: Blood. 108, 5, p. 1744-1750Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing
Nagasawa, T., Zhang, Q., Raghunath, P. N., Wong, H. Y., El-Salem, M., Szallasi, A., Marzec, Michal Tomasz, Gimotty, P., Rook, A. H., Vonderheid, E. C., Ødum, Niels & Wasik, M. A., 2006, In: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 30, 3, p. 303-12 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Jak3 contributes to the activation of ALK and Stat3 in ALK + anaplastic large cell lymphoma. Response.
Wasik, M. A. & Marzec, Michal Tomasz, 2006, In: Laboratory Investigation. 86, 4, p. 420-421 2 p.Research output: Contribution to journal › Letter › Research
- 2007
Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders.
El-Salem, M., Raghunath, P. N., Marzec, Michal Tomasz, Wlodarski, P., Tsai, D., Hsi, E. & Wasik, M. A., 2007, In: Laboratory Investigation. 87, 1, p. 29-39 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.
Marzec, Michal Tomasz, Kasprzycka, M., Liu, X., Raghunath, P. N., Wlodarski, P. & Wasik, M. A., 2007, In: Oncogene. 26, 6, p. 813-821 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.
Marzec, Michal Tomasz, Kasprzycka, M., Liu, X., El-Salem, M., Halasa, K., Raghunath, P. N., Bucki, R., Wlodarski, P. & Wasik, M. A., 2007, In: Oncogene. 26, 38, p. 5606-5614 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
PU.1 activates transcription of SHP-1 gene in hematopoietic cells.
Wlodarski, P., Zhang, Q., Liu, X., Kasprzycka, M., Marzec, Michal Tomasz & Wasik, M. A., 2007, In: Journal of Biological Chemistry. 282, 9, p. 6316-6323 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4(+) T lymphocytes
Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, Michal Tomasz, Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Ødum, Niels & Wasik, M. A., 15 Aug 2008, In: Journal of Immunology. 181, 4, p. 2506-2512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
γc-Signaling Cytokines Induce a Regulatory T Cell Phenotype in Malignant CD4+ T Lymphocytes.
Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, Michal Tomasz, Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Ødum, Niels & Wasik, M. A., 2008, In: Journal of Immunology. 181, 4, p. 2506-2512 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells
Marzec, Michal Tomasz, Halasa, K., Kasprzycka, M., Wysocka, M., Liu, X., Tobias, J. W., Baldwin, D., Zhang, Q., Ødum, Niels, Rook, A. H. & Wasik, M. A., 2008, In: Cancer Research. 68, 4, p. 1083-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes
Marzec, Michal Tomasz, Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Ødum, Niels & Wasik, M. A., 2008, In: Blood. 111, 4, p. 2181-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
Marzec, Michal Tomasz, Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M., Wang, H. Y., Wysocka, M., Cheng, M., Ruggeri, B. A. & Wasik, M. A., 30 Dec 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20852-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of FOXP3(+) regulatory T-cell phenotype in neoplastic and reactive cells in early mycosis fungoides
Witkiewicz, A. K., Potoczek, M., Kasprzycka, M., Marzec, Michal Tomasz & Wasik, M., Jan 2008, In: Modern Pathology. 21, p. 103A-103AResearch output: Contribution to journal › Journal article › Research › peer-review
- 2009
Activation of mTORC1 signaling pathway in AIDS-related lymphomas.
El-Salem, M., Raghunath, P. N., Marzec, Michal Tomasz, Liu, X., Kasprzycka, M., Robertson, E. & Wasik, M. A., 2009, In: American Journal of Pathology. 175, 2, p. 817-824 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches
Wasik, M. A., Zhang, Q., Marzec, Michal Tomasz, Kasprzycka, M., Wang, H. Y. & Liu, X., 2009, In: Seminars in Oncology. 36, 2 Suppl 1, p. S27-35Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
Plasma gelsolin modulates cellular response to sphingosine 1-phosphate
Bucki, R., Kulakowska, A., Byfield, F. J., Zendzian-Piotrowska, M., Baranowski, M., Marzec, Michal Tomasz, Winer, J. P., Ciccarelli, N. J., Gorski, J., Drozdowski, W., Bittman, R. & Janmey, P. A., 2010, In: American Journal of Physiology: Cell Physiology. 299, 6, p. C1516-23Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Oncogenic kinase NPM/ALK induces expression of HIF1 alpha mRNA
Marzec, Michal Tomasz, Liu, X., Wong, W., Yang, Y., Pasha, T., Kantekure, K., Zhang, P., Woetmann, Anders , Cheng, M., Ødum, Niels & Wasik, M. A., 2011, In: Oncogene. 30, 11, p. 1372-1378 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells
Marzec, Michal Tomasz, Liu, X., Wysocka, M., Rook, A. H., Ødum, Niels & Wasik, M. A., 16 Sep 2011, In: PLoS ONE. 6, 9, 8 p., e24849.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Prediction and Early Detection of Response by NMR Spectroscopy and Imaging
Lee, S., Arias-Mendoza, F., Poptani, H., Delikatny, E. J., Wasik, M., Marzec, Michal Tomasz, Schuster, S. J., Nasta, S. D., Svoboda, J., O'Connor, O. A., Smith, M. R. & Glickson, J. D., Jan 2012, In: PET Clinics. 7, 1, p. 119-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
Marzec, Michal Tomasz, Eletto, D. & Argon, Y., Mar 2012, In: B B A - Reviews on Cancer. 1823, 3, p. 774-87 14 p.Research output: Contribution to journal › Review › Research › peer-review
- 2013
Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.
Lee, S., Marzec, Michal Tomasz, Liu, X., Wehrli, S., Kantekure, K., Ragunath, P. N., Nelson, D. S., Delikatny, E. J., Glickson, J. D. & Wasik, M. A., 2013, In: NMR in Biomedicine. 26, 1, p. 106-114 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming
Marzec, Michal Tomasz, Halasa, K., Liu, X., Wang, H. Y., Cheng, M., Baldwin, D., Tobias, J. W., Schuster, S. J., Woetmann, Anders , Zhang, Q., Turner, S. D., Ødum, Niels & Wasik, M. A., 15 Dec 2013, In: Journal of immunology (Baltimore, Md. : 1950). 191, 12, p. 6200-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Variation in GRP94 Activity Impacts Production of Igfs and Human Growth
Argon, Y., Grimberg, A., Rosenfeld, R. G. & Marzec, Michal Tomasz, 2014, In: Endocrine Reviews. 35, 3Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Utility of blood procalcitonin concentration in the management of cancer patients with infections
Durnas, B., Watek, M., Wollny, T., Niemirowicz, K., Marzec, Michal Tomasz, Bucki, R. & Gozdz, S., 2016, In: OncoTargets and Therapy. 9, p. 469-475Research output: Contribution to journal › Review › Research › peer-review
- Published
A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production
Marzec, Michal Tomasz, Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, Oluf Borbye, Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., May 2016, In: Endocrinology. 157, 5, p. 1914-1928 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia
WAtek, M., Wollny, T., Pasiarski, M., Gozdz, S., Durnas, B., Wolak, P., Bucki, R., Marzec, Michal Tomasz, Chabowska, A. & Zendzian-Piotrowska, M., 2017, In: Lipids in Health and Disease. 16, 1Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Students’ supervision and introduction during the initial period in the research laboratory: does it matter?
Marzec, Michal Tomasz, 2018, Improving University Science Teaching and Learning: Pedagogical Projects 2018. Department of Science Education, University of Copenhagen, Denmark, p. 107-114 8 p. (Improving University Science Teaching and Learning - Pedagogical Projects, Vol. 12).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2019
- Published
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling
Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, Celina, Bresson, S. E., Khilji, Muhammad Saad, Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, Apr 2019, In: Diabetes. 68, 4, p. 747-760 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MCPIP1 regulates insulin biosynthesis and glucose-stimulated insulin secretion: [Meeting Abstract]
Tyka, K., Brydde, T. H., Wilamowski, M., Jura, J., Marzec, Michal Tomasz & Gurgul-Convey, E., 2019, In: FEBS Open Bio. 9, S1, p. 87-87 P-01-064.Research output: Contribution to journal › Conference abstract in journal › Research
- 2020
- Published
Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production
Argon, Y., Bresson, S. E., Marzec, Michal Tomasz & Grimberg, A., 2020, In: Cells. 9, 8, 12 p., 1844.Research output: Contribution to journal › Review › Research › peer-review
- Published
Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in beta-Cells
Dahlby, T., Simon, C., Backe, M. B., Dahllof, M. S., Holson, E., Wagner, B. K., Boni-Schnetzler, M., Marzec, Michal Tomasz, Lundh, M. & Mandrup-Poulsen, Thomas, 2020, In: International Journal of Molecular Sciences. 21, 21, 18 p., 8016.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The inducible beta 5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets
Khilji, Muhammad Saad, Bresson, S. E., Verstappen, D., Pihl, Celina, Andersen, Phillip Alexander Keller, Agergaard, Jette Bach, Dahlby, T., Holgersen Bryde, Tenna, Klindt, K., Nielsen, C. K., Walentinsson, A., Zivkovic, D., Bousquet, M., Tyrberg, B., Richardson, S. J., Morgan, N. G., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 318, 6, p. E892-E900Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β
Khilji, Muhammad Saad, Verstappen, D., Dahlby, T., Prause, Michala Cecilie Burstein, Pihl, Celina, Bresson, S. E., Holgersen Bryde, Tenna, Andersen, Phillip Alexander Keller, Klindt, K., Zivkovic, D., Bousquet-Dubouch, M. P., Tyrberg, B., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2020, In: PLoS ONE. 15, 2, 21 p., e0222432.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In silico approach to predict pancreatic β-cells classically secreted proteins
Pinheiro-Machado, E., Sandberg, T. O. M., Pihl, Celina, Hägglund, Per Mårten & Marzec, Michal Tomasz, 1 Jan 2020, In: Bioscience Reports. 40, 2, 13 p., BSR20193708.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model
Piktel, E., Oscilowska, I., Suprewicz, Ł., Depciuch, J., Marcińczyk, N., Chabielska, E., Wolak, P., Głuszek, K., Klimek, J., Zieliński, P. M., Marzec, Michal Tomasz, Savage, P. B., Parlińska-Wojtan, M. & Bucki, R., 2021, In: Cancers. 13, 21, p. 1-26 5424.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MCPIP1 is a novel link between diabetogenic conditions and impaired insulin secretory capacity
Tyka, K., Joerns, A., Dunst, A., Tang, Y., Holgersen Bryde, Tenna, Mehmeti, I., Walentinsson, A., Marselli, L., Cnop, M., Tyrberg, B., Marzec, Michal Tomasz & Gurgul-Convey, E., 2021, In: B B A - Molecular Basis of Disease. 1867, 10, 12 p., 166199.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells
Khilji, Muhammad Saad, Faridi, P., Pinheiro-Machado, E., Hoefner, C., Dahlby, T., Aranha, R., Buus, Søren, Nielsen, M., Klusek, J., Mandrup-Poulsen, Thomas, Pandey, K., Purcell, A. W. & Marzec, Michal Tomasz, 2022, In: Biomedicines. 10, 4, 814.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
FK506-Binding Protein 2 Participates in Proinsulin Folding
Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, , 2023, In: Biomolecules. 13, 1, 20 p., 152.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IDF2022-0254 Glutathione S-transferase P1 genetic variants influence the HbA1c level in diabetic patients
Klusek, J., Głuszek, S., Orlewska, K., Marzec, Michal Tomasz, Wawszczak-kasza, M., Madej, Ł., Klusek, J., Witczak, B. & Orlewska, E., 2023, In: Diabetes Research and Clinical Practice. 197, Suppl. 1, 1 p., 110268.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients
Orlewska, K., Klusek, J., Głuszek, S., Klusek, J., Witczak, B., Wawszczak, M., Madej, Ł., Marzec, Michal Tomasz & Orlewska, E., 2023, In: International Journal of Environmental Research and Public Health. 20, 2, 9 p., 1520.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunometabolism in type 2 diabetes mellitus: tissue-specific interactions
Pinheiro-Machado, E., Convey, E. G. & Marzec, Michal Tomasz, 2023, In: Archives of Medical Science. 19, 4, 17 p.Research output: Contribution to journal › Review › Research › peer-review
- 2024
- Published
NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer
Klusek, J., Lewitowicz, P., Oblap, R., Orlewska, E., Witczak, B., Marzec, Michal Tomasz, Kozłowska-Geller, M., Nawacki, Ł., Wawszczak-Kasza, M., Kocańda, K., Jóźwik, A. & Głuszek, S., 2024, In: Journal of Clinical Medicine. 13, 4, 11 p., 937.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 129941679
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Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells
Research output: Contribution to journal › Journal article › Research › peer-review
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Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
90
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The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β
Research output: Contribution to journal › Journal article › Research › peer-review
Published