Syndecan proteoglycans and cell adhesion.

Research output: Contribution to journalJournal articleResearchpeer-review

A Woods, E S Oh, J R Couchman

It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.
Original languageEnglish
JournalMatrix Biology
Volume17
Issue number7
Pages (from-to)477-83
Number of pages6
ISSN0945-053X
Publication statusPublished - 1998

Bibliographical note

Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Cell Membrane; Cytoplasm; Cytoskeleton; Heparitin Sulfate; Humans; Membrane Glycoproteins; Molecular Sequence Data; Proteoglycans; Syndecans

ID: 5164472