Protein kinase C, focal adhesions and the regulation of cell migration
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Protein kinase C, focal adhesions and the regulation of cell migration. / Fogh, Betina S; Multhaupt, Hinke A B; Couchman, John Robert.
In: Journal of Histochemistry and Cytochemistry, Vol. 62, No. 3, 03.2014, p. 172-84.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Protein kinase C, focal adhesions and the regulation of cell migration
AU - Fogh, Betina S
AU - Multhaupt, Hinke A B
AU - Couchman, John Robert
PY - 2014/3
Y1 - 2014/3
N2 - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.
AB - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.
KW - Animals
KW - Cell Movement
KW - Enzyme Activation
KW - Focal Adhesions
KW - Humans
KW - Protein Kinase C
U2 - 10.1369/0022155413517701
DO - 10.1369/0022155413517701
M3 - Review
C2 - 24309511
VL - 62
SP - 172
EP - 184
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
SN - 0022-1554
IS - 3
ER -
ID: 109873086