Protein kinase C, focal adhesions and the regulation of cell migration

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Protein kinase C, focal adhesions and the regulation of cell migration. / Fogh, Betina S; Multhaupt, Hinke A B; Couchman, John Robert.

In: Journal of Histochemistry and Cytochemistry, Vol. 62, No. 3, 03.2014, p. 172-84.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Fogh, BS, Multhaupt, HAB & Couchman, JR 2014, 'Protein kinase C, focal adhesions and the regulation of cell migration', Journal of Histochemistry and Cytochemistry, vol. 62, no. 3, pp. 172-84. https://doi.org/10.1369/0022155413517701

APA

Fogh, B. S., Multhaupt, H. A. B., & Couchman, J. R. (2014). Protein kinase C, focal adhesions and the regulation of cell migration. Journal of Histochemistry and Cytochemistry, 62(3), 172-84. https://doi.org/10.1369/0022155413517701

Vancouver

Fogh BS, Multhaupt HAB, Couchman JR. Protein kinase C, focal adhesions and the regulation of cell migration. Journal of Histochemistry and Cytochemistry. 2014 Mar;62(3):172-84. https://doi.org/10.1369/0022155413517701

Author

Fogh, Betina S ; Multhaupt, Hinke A B ; Couchman, John Robert. / Protein kinase C, focal adhesions and the regulation of cell migration. In: Journal of Histochemistry and Cytochemistry. 2014 ; Vol. 62, No. 3. pp. 172-84.

Bibtex

@article{7c015293cb094036b57cde24e77122b8,
title = "Protein kinase C, focal adhesions and the regulation of cell migration",
abstract = "Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.",
keywords = "Animals, Cell Movement, Enzyme Activation, Focal Adhesions, Humans, Protein Kinase C",
author = "Fogh, {Betina S} and Multhaupt, {Hinke A B} and Couchman, {John Robert}",
year = "2014",
month = "3",
doi = "10.1369/0022155413517701",
language = "English",
volume = "62",
pages = "172--84",
journal = "Journal of Histochemistry and Cytochemistry",
issn = "0022-1554",
publisher = "SAGE Publications",
number = "3",

}

RIS

TY - JOUR

T1 - Protein kinase C, focal adhesions and the regulation of cell migration

AU - Fogh, Betina S

AU - Multhaupt, Hinke A B

AU - Couchman, John Robert

PY - 2014/3

Y1 - 2014/3

N2 - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.

AB - Cell adhesion to extracellular matrix is a complex process involving protrusive activity driven by the actin cytoskeleton, engagement of specific receptors, followed by signaling and cytoskeletal organization. Thereafter, contractile and endocytic/recycling activities may facilitate migration and adhesion turnover. Focal adhesions, or focal contacts, are widespread organelles at the cell-matrix interface. They arise as a result of receptor interactions with matrix ligands, together with clustering. Recent analysis shows that focal adhesions contain a very large number of protein components in their intracellular compartment. Among these are tyrosine kinases, which have received a great deal of attention, whereas the serine/threonine kinase protein kinase C has received much less. Here the status of protein kinase C in focal adhesions and cell migration is reviewed, together with discussion of its roles and potential substrates.

KW - Animals

KW - Cell Movement

KW - Enzyme Activation

KW - Focal Adhesions

KW - Humans

KW - Protein Kinase C

U2 - 10.1369/0022155413517701

DO - 10.1369/0022155413517701

M3 - Review

C2 - 24309511

VL - 62

SP - 172

EP - 184

JO - Journal of Histochemistry and Cytochemistry

JF - Journal of Histochemistry and Cytochemistry

SN - 0022-1554

IS - 3

ER -

ID: 109873086