Protecting the mitochondrial powerhouse

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Protecting the mitochondrial powerhouse. / Scheibye-Knudsen, Morten; Fang, Evandro F.; Croteau, Deborah L.; Wilson, David M.; Bohr, Vilhelm A.

In: Trends in Cell Biology, Vol. 25, No. 3, 01.03.2015, p. 158-170.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Scheibye-Knudsen, M, Fang, EF, Croteau, DL, Wilson, DM & Bohr, VA 2015, 'Protecting the mitochondrial powerhouse', Trends in Cell Biology, vol. 25, no. 3, pp. 158-170. https://doi.org/10.1016/j.tcb.2014.11.002

APA

Scheibye-Knudsen, M., Fang, E. F., Croteau, D. L., Wilson, D. M., & Bohr, V. A. (2015). Protecting the mitochondrial powerhouse. Trends in Cell Biology, 25(3), 158-170. https://doi.org/10.1016/j.tcb.2014.11.002

Vancouver

Scheibye-Knudsen M, Fang EF, Croteau DL, Wilson DM, Bohr VA. Protecting the mitochondrial powerhouse. Trends in Cell Biology. 2015 Mar 1;25(3):158-170. https://doi.org/10.1016/j.tcb.2014.11.002

Author

Scheibye-Knudsen, Morten ; Fang, Evandro F. ; Croteau, Deborah L. ; Wilson, David M. ; Bohr, Vilhelm A. / Protecting the mitochondrial powerhouse. In: Trends in Cell Biology. 2015 ; Vol. 25, No. 3. pp. 158-170.

Bibtex

@article{93ebe2ffee92476ca2837e6352e92994,
title = "Protecting the mitochondrial powerhouse",
abstract = "Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.",
keywords = "Disease, DNA repair, Mitochondria, Mitophagy, Reactive oxygen species",
author = "Morten Scheibye-Knudsen and Fang, {Evandro F.} and Croteau, {Deborah L.} and Wilson, {David M.} and Bohr, {Vilhelm A.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.tcb.2014.11.002",
language = "English",
volume = "25",
pages = "158--170",
journal = "Trends in Cell Biology",
issn = "0962-8924",
publisher = "Elsevier Ltd. * Trends Journals",
number = "3",

}

RIS

TY - JOUR

T1 - Protecting the mitochondrial powerhouse

AU - Scheibye-Knudsen, Morten

AU - Fang, Evandro F.

AU - Croteau, Deborah L.

AU - Wilson, David M.

AU - Bohr, Vilhelm A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

AB - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

KW - Disease

KW - DNA repair

KW - Mitochondria

KW - Mitophagy

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=84922800677&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2014.11.002

DO - 10.1016/j.tcb.2014.11.002

M3 - Review

VL - 25

SP - 158

EP - 170

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 3

ER -

ID: 172128071