Protecting the mitochondrial powerhouse
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Protecting the mitochondrial powerhouse. / Scheibye-Knudsen, Morten; Fang, Evandro F.; Croteau, Deborah L.; Wilson, David M.; Bohr, Vilhelm A.
In: Trends in Cell Biology, Vol. 25, No. 3, 01.03.2015, p. 158-170.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Protecting the mitochondrial powerhouse
AU - Scheibye-Knudsen, Morten
AU - Fang, Evandro F.
AU - Croteau, Deborah L.
AU - Wilson, David M.
AU - Bohr, Vilhelm A.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.
AB - Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.
KW - Disease
KW - DNA repair
KW - Mitochondria
KW - Mitophagy
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=84922800677&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2014.11.002
DO - 10.1016/j.tcb.2014.11.002
M3 - Review
C2 - 25499735
AN - SCOPUS:84922800677
VL - 25
SP - 158
EP - 170
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 3
ER -
ID: 172128071