Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice
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Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice. / Jensen, Mette Munk; Erichsen, Kamille Dumong; Björkling, Fredrik; Madsen, Jacob; Jensen, Peter Buhl; Højgaard, Liselotte; Sehested, Maxwell; Kjær, Andreas.
In: P L o S One, Vol. 5, No. 9, 01.01.2010, p. e12965.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice
AU - Jensen, Mette Munk
AU - Erichsen, Kamille Dumong
AU - Björkling, Fredrik
AU - Madsen, Jacob
AU - Jensen, Peter Buhl
AU - Højgaard, Liselotte
AU - Sehested, Maxwell
AU - Kjær, Andreas
PY - 2010/1/1
Y1 - 2010/1/1
N2 - 3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.
AB - 3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.
KW - Animals
KW - Antineoplastic Agents
KW - Cell Proliferation
KW - Dideoxynucleosides
KW - Disease Models, Animal
KW - Drug Monitoring
KW - Female
KW - Fluorodeoxyglucose F18
KW - Humans
KW - Mice
KW - Mice, Nude
KW - Ovarian Neoplasms
KW - Positron-Emission Tomography
KW - Radiopharmaceuticals
KW - Xenograft Model Antitumor Assays
U2 - 10.1371/journal.pone.0012965
DO - 10.1371/journal.pone.0012965
M3 - Journal article
C2 - 20885974
VL - 5
SP - e12965
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
ER -
ID: 34044950