Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

Research output: Contribution to journalJournal articleResearchpeer-review

Jean Cadet, Steffen Loft, Ryszard Olinski, Mark D Evans, Karol Bialkowski, J Richard Wagner, Peter C Dedon, Peter Møller, Marc M Greenberg, Marcus S Cooke

A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
Original languageEnglish
JournalFree Radical Research
Volume46
Issue number4
Pages (from-to)367-81
Number of pages15
ISSN1071-5762
DOIs
Publication statusPublished - 2012

ID: 38170671