Transport engineering in microbial cell factories producing plant-specialized metabolites
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Transport engineering in microbial cell factories producing plant-specialized metabolites. / Belew, Zeinu Mussa; Poborsky, Michal; Nour-Eldin, Hussam Hassan; Halkier, Barbara Ann.
In: Current Opinion in Green and Sustainable Chemistry, Vol. 33, 100576, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Transport engineering in microbial cell factories producing plant-specialized metabolites
AU - Belew, Zeinu Mussa
AU - Poborsky, Michal
AU - Nour-Eldin, Hussam Hassan
AU - Halkier, Barbara Ann
N1 - Publisher Copyright: © 2021 Elsevier B.V.
PY - 2022
Y1 - 2022
N2 - Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.
AB - Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.
KW - Feedback inhibition
KW - Metabolic engineering
KW - Microbial cell factories
KW - Pathway engineering
KW - Plant specialized metabolites
KW - Transport engineering
U2 - 10.1016/j.cogsc.2021.100576
DO - 10.1016/j.cogsc.2021.100576
M3 - Review
AN - SCOPUS:85122105771
VL - 33
JO - Current Opinion in Green and Sustainable Chemistry
JF - Current Opinion in Green and Sustainable Chemistry
SN - 2452-2236
M1 - 100576
ER -
ID: 289158684