TOPping up ATR activity

Research output: Contribution to journalComment/debateResearchpeer-review

The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

Original languageEnglish
Issue number5
Pages (from-to)888-90
Number of pages3
Publication statusPublished - 10 Mar 2006
Externally publishedYes

    Research areas

  • Animals, Ataxia Telangiectasia Mutated Proteins, Carrier Proteins, Cell Cycle Proteins, DNA Repair, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Humans, Models, Genetic, Nuclear Proteins, Protein-Serine-Threonine Kinases, Xenopus Proteins

ID: 124903417