Topoisomerase 1(TOP1) gene copy number in stage III colorectal cancer patients and its relation to prognosis

Research output: Contribution to journalJournal articleResearchpeer-review

  • Maria Unni Koefoed Rømer
  • Sune Boris Nygård
  • Ib Jarle Christensen
  • Nielsen, Signe Lykke
  • Kirsten Vang Nielsen
  • Sven Müller
  • David Hersi Smith
  • Ben Vainer
  • Hans Jørgen Nielsen
  • Nils Brünner
A Topoisomerase 1 (Top1) poison is frequently included in the treatment regimens for metastatic colorectal cancer (mCRC). However, no predictive biomarkers for Top1 poisons are available. We here report a study on the TOP1 gene copy number in CRC patients and its association with patient prognosis and tumor cell proliferation.
Original languageEnglish
JournalMolecular Oncology
Issue number1
Pages (from-to)101-111
Number of pages11
Publication statusPublished - 2013

ID: 40707423